Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus

Campos, Lúcia; Kiss, Mária; D'Ámico, Elbio Antônio; Silva, Clóvis A.

doi:10.1590/s0041-87812003000300005

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…A drawback of our study is that we could test only for GM1 autoantibodies. Other autoantibodies that have been described in acute transverse myelitis include antiphospholipid antibodies, anti-Ro antibodies, and neuromyelitis optica-immunoglobulin G. [26][27][28] Neuromyelitis optica-immunoglobulin G is an aquaporin-4-specific water channel antibody, which has been associated with neuromyelitis optica and longitudinally extensive transverse myelitis in adults. 28 A recent study described the clinical and radiological features of children with neuromyelitis optica-immunoglobulin G seropositivity.…”

Section: Discussionmentioning

confidence: 99%

Childhood Acute Transverse Myelitis: Clinical Profile, Outcome, and Association With Antiganglioside Antibodies

et al. 2009

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Prospectively, in 15 children the association of acute transverse myelitis with Campylobacter jejuni infection and antiganglioside antibodies was studied. The clinical profile, radiological findings, and treatment outcome in these children were analyzed. Stool culture and serology for Campylobacter jejuni and antiganglioside antibodies were tested. In all, 15 age- and sex-matched healthy controls were tested for evidence of Campylobacter jejuni infection and antiganglioside antibodies. Anti-GM1 antiganglioside immunoglobulin G antibodies were found in 46% of patients with acute transverse myelitis versus 6.6% of controls (P = .035). Evidence of Campylobacter jejuni infection was absent in both the groups. The magnetic resonance imaging revealed longitudinally extensive lesions in majority. All children underwent intravenous high-dose corticosteroid treatment. At 1-year follow-up, 8 children had recovered completely, whereas 3 were nonambulatory. Bladder disturbances persisted in 7. The significance of these findings and the possible role antiganglioside antibodies may play in acute transverse myelitis pathophysiology is discussed.

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Section: Discussionmentioning

confidence: 99%

Childhood Acute Transverse Myelitis: Clinical Profile, Outcome, and Association With Antiganglioside Antibodies

et al. 2009

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“…Le pic de masse osseuse est également diminué chez les enfants lupiques, ce qui soulève des problèmes de prise en charge à long terme du capital osseux avec la prise répétée de corticoïdes tout au long de la vie. L'ostéonécrose survient dans prêt de 15 % des enfants lupiques [25].…”

Section: Os Et Croissanceunclassified

Le lupus de l’enfant à travers les âges

Belot

Cimaz

2012

Revue du Rhumatisme Monographies

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“…There is predominance in females (especially in secondary APS) and no race predominance; a higher incidence was observed in young individuals and middle-aged adults, although the syndrome can manifest in children and elderly. There are reports of its occurrence in infants of less than eight months of age (6,8) .…”

Section: Introductionmentioning

confidence: 99%

Síndrome antifosfolípide e trombocitopenia na infância

Turini¹,

Chechia²,

Fernandes³

et al. 2012

Rev. paul. pediatr.

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Objective: To report the case of a child diagnosed with antiphospholipid syndrome associated with severe thrombocytopenia, and to review the literature on the subject.Case description: Child aged nine years and eight months old with severe thrombocytopenia associated with a positive anticardiolipin antibody. Data were collected by clinical history, physical examination, and laboratorial exams. Diagnosis was confirmed according to criteria established for the antiophospholipid syndrome, associated with the presence of the most common manifestations of the syndrome in children: livedo reticularis and thrombocytopenia.Comments: The antiphospholipid syndrome is an uncommon pediatric disease, and clinical manifestations such as decreased platelet number should be considered.

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Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus

Abstract: The frequencies of antiphospholipid antibodies in children and adolescents with lupus erythematosus were similar to those observed in adults. The positivity fluctuated during the follow-up and was not correlated with clinical and/or laboratory disease parameters.

Cited by 8 publications

References 8 publications

Childhood Acute Transverse Myelitis: Clinical Profile, Outcome, and Association With Antiganglioside Antibodies

Childhood Acute Transverse Myelitis: Clinical Profile, Outcome, and Association With Antiganglioside Antibodies

Le lupus de l’enfant à travers les âges

Síndrome antifosfolípide e trombocitopenia na infância

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