Burkitt-like lymphoma in an infant: a case report

Klumb, Claudete Esteves; Resende, Lídia Maria Magalhães de; Stefanoff, Cláudio Gustavo; Vicuña, Carlos; Renault, Ilana Zalcberg; Maia, Raquel Ciuvalschi

doi:10.1590/s0041-87812003000100007

Cited by 5 publications

(4 citation statements)

References 19 publications

(17 reference statements)

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“…There is almost 100% correspondence of EBV presence in endemic Burkitt's lymphoma; sporadic cases are uncommon and the association with EBV is much lower (Kutok and Wang, 2006). International studies indicate, however, that in most developing countries outside Africa, 50–90% of Burkitt's lymphoma cases are EBV positive (Magrath, 1997) leading to speculation that early EBV infection associated with lower SES status and other environmental factors may be relevant in these areas (Klumb et al , 2003). This pattern would support our finding of two- to three-fold increased ORs for Burkitt's lymphoma in the lowest category of parental educational attainment.…”

Section: Discussionmentioning

confidence: 99%

Parental educational attainment as an indicator of socioeconomic status and risk of childhood cancers

et al. 2010

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Background:Little has been reported on socioeconomic (SES) patterns of risk for most forms of childhood cancer.Methods:Population-based case–control data from epidemiological studies of childhood cancer conducted in five US states were pooled and associations of maternal, paternal and household educational attainment with childhood cancers were analysed. Odds ratios (ORs) and 95% confidence intervals were estimated using logistic regression, controlling for confounders.Results:Although there was no association with parental education for the majority of cancers evaluated, there was an indication of a positive association with lower education for Hodgkin's and Burkitt's lymphoma and Wilm's tumour, with the ORs ranging from 1.5 to >3.0 times that of more educated parents. A possible protective effect was seen for lower parental education and astrocytoma and hepatoblastoma, with ORs reduced by 30 to 40%.Conclusions:These study results should be viewed as exploratory because of the broad nature of the SES assessment, but they give some indication that childhood cancer studies might benefit from a more thorough assessment of SES.

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Section: Discussionmentioning

confidence: 99%

Parental educational attainment as an indicator of socioeconomic status and risk of childhood cancers

et al. 2010

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“…[19][20][21] With initiation of chemotherapy, this patients often suffers from tumor lysis syndrome. This higher percentage could be due to sample bias.…”

Section: Prognosismentioning

confidence: 99%

“…In some cases with high-grade lymphoma such as Burkitt's and lymphoblastic lymphoma patients often present with massive diseases including pleural and ascitic fluid. [19][20][21] With initiation of chemotherapy, this patients often suffers from tumor lysis syndrome. Examination of pleural fluid on such cases not only offers a diagnosis of lymphoma but can also help notifying the oncologist regarding tumor lysis syndrome, so that appropriate therapy can be provided and further complications can be avoided.…”

Section: Prognosismentioning

confidence: 99%

The value of cytology in diagnosis of serous effusions in malignant lymphomas: An experience of a tertiary care center

Patel

Mehta

et al. 2019

Diagnostic Cytopathology

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Background: Malignant lymphomas (ML) are often complicated by serous effusions.The present study is an attempt to cytologically assess a large series of serous effusions associated with ML, identify the immunoreactivity of cells and to evaluate the role of various ancillary methods in confirming and subtyping these cases. Methods: A cross-sectional study of 4612 serous effusions was undertaken at the Department of Cytology, Gujarat Cancer and Research Institute by retrieving data from the year 2015 to 2017. Total 169 cases of ML, clinically suspicious, were included. All cerebrospinal fluids, serous effusions involved by myeloid neoplasms, and cases of primary effusion lymphomas were excluded from our study. Pap stained smears of all these serous effusions were examined. Ancillary methods such as immunohistochemistry were used to further subtype the positive cases using the WHO classification of hematopoietic and lymphoid neoplasms (2016). Results: Out of total 169 clinically suspicious cases, 109 cases were cytologically positive for ML which included 73 (66.9%) pleural effusions, 34 (31.1%) ascitic fluids, and 2 (1.8%) pericardial effusions. T-lymphoblastic lymphoma (36.9%) and Burkitt's lymphoma (38.2%) were the most common ML involving the pleural and ascitic fluids respectively. Non-Hodgkin's lymphoma (NHL) more frequently involved the serous cavities than Hodgkin's lymphoma. (P value <.0001). Among the NHL, T-cell lymphomas more commonly lead to serous effusions than B-cell lymphomas (P value <.0048). Conclusion: Cytological examination of serous effusions is an accurate, prompt, affordable technique having diagnostic and therapeutic implications. With the help of ancillary methods, we can identify the phenotype of cells, classify as well as confirm our diagnosis. K E Y W O R D S immunohistochemistry, malignant lymphomas, serous effusions

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“…It is observed that patients with high-grade lymphomas like Burkitt's lymphoma 134,135 and lymphoblastic lymphoma 136 often present with massive disease including pleural effusion and ascites. With the initiation of chemotherapy, especially following administration of dexame-thasone, these patients suffer from acute tumor lysis syndrome.…”

Section: Prognostic Outcome In Lymphoma Cases With Serous Effusions Amentioning

confidence: 99%

Serous effusions in malignant lymphomas: A review

Das

2006

Diagnostic Cytopathology

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Serous effusions are a common complication of lymphomas. Although the frequency of pleural effusion is 20-30% in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD), the involvement of peritoneal and pericardial cavities is uncommon. Among lymphoma subtypes, T-cell neoplasms, especially the lymphoblastic lymphomas, more frequently involve the serous fluids. The thoracic duct obstruction and impaired lymphatic drainage appear to be the primary mechanism for pathogenesis of pleural effusion in HD and direct pleural infiltration is the predominant cause in NHL. There is wide variation in rate of positive cytologic findings of NHL in pleural effusion (22.2-94.1%). Cytologic features of specific lymphoma subtypes such as lymphoblastic lymphoma, follicular center cell lymphoma, including Burkitt-type lymphoma, marginal zone lymphoma, MALT lymphoma, and anaplastic large-cell lymphoma, etc., have been described in the literature. The differential diagnostic problems of lymphomas in serous effusions include reactive lymphocytoses, early involvement by lymphomatous process, small round-cell tumors (SRCT), and presence of look-alike of Reed-Sternberg cells. To overcome these difficulties, various ancillary studies, including immunocytochemistry (ICC), morphometry, flow cytometry (FCM), and cytogenetics/molecular genetics (PCR, in-situ hybridization, and Southern blotting), have been performed on effusion specimens. ICC not only distinguishes lymphomas from reactive lymphocytoses and SRCTs, it significantly modifies the morphologic diagnosis to achieve a better classification of lymphomas. Combined morphology and immunophenotyping by FCM, has a sensitivity as well as specificity of 100%. Morphometry also distinguishes reactive lymphocytoses from malignant lymphoma with a high degree of sensitivity (>85%) and specificity (>95%). Limitations of individual ancillary techniques can be overcome by using multiple parameters. Although lymphomas rarely present as serous effusions without the involvement of other thoracic and extrathoracic sites, a small group of lymphomas called primary effusion lymphomas (PEL) exhibit exclusive or dominant involvement of serous cavities, without a detectable solid tumor mass. This body cavity based lymphoma (BCBL) is a distinct clinicopathologic entity and is found predominantly in AIDS patients with preexisting Kaposi sarcoma. In the absence of obstructive or infiltrative tumor mass, its pathogenesis has been attributed to stimulation by vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF), leading to vascular leakage. Cytomorphologically, PEL is usually a large-cell lymphoma, which appears to bridge features of large-cell immunoblastic and anaplastic large-cell lymphoma (ALCL). Most of these cases comprise a unique subgroup of B-cell lymphoma, with features of both high-grade anaplastic and B-immunoblastic lymphoma, but T-cell and/or natural killer cell immunophenotypes are described. Its association with various viral DNAs has been studied in detail by molecular techn...

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Burkitt-like lymphoma in an infant: a case report

Cited by 5 publications

References 19 publications

Parental educational attainment as an indicator of socioeconomic status and risk of childhood cancers

Parental educational attainment as an indicator of socioeconomic status and risk of childhood cancers

The value of cytology in diagnosis of serous effusions in malignant lymphomas: An experience of a tertiary care center

Serous effusions in malignant lymphomas: A review

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