Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus

Liphaus, Bernadete de Lourdes; Goldberg, Anna Carla; Kiss, Mária; Silva, Clóvis A.

doi:10.1590/s0041-87812002000600006

Cited by 14 publications

(10 citation statements)

References 24 publications

(5 reference statements)

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“…Therefore, case control association tests are still being widely used to map disease susceptibility genes [20-22]. However, spurious association may result, if the study groups are not well matched in ethnicity.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2003

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Background: SP-A, SP-B, and SP-D are pulmonary surfactant proteins. Several linkage and association studies have been done using these genes as markers to locate pulmonary disease susceptibility genes, but few have studied the markers systematically in different ethnic groups. Here we studied eight markers in SP-A, SP-B, and SP-D genes in seven ethnic groups from three races (Caucasian, Black and Hispanic). We measured the similarity of the marker distribution among the ethnic groups in order to see whether people in different ethnic groups or races could be mixed together for linkage and association studies. To evaluate the usefulness of these markers, we estimated the informativeness of each marker loci in the seven ethnic groups by assessing their heterozygosity and PIC values. We also conducted linkage disequilibrium (LD) analysis to identify associated marker loci and to estimate the haplotype frequencies in each of the seven ethnic groups in an attempt to find valuable haplotypes so that the level of polymorphism of the "markers" could be increased.

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Section: Discussionmentioning

confidence: 99%

Untitled

2003

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“…The major histocompatibility complex (MHC) genotype determines which MHC molecules are available to the antigens and thus how well the antigens can be recognized by T cells. Particular MHC genes have been associated with an increased risk of an immune response to self-antigens and hence an increased risk of disease development, such as that observed in SLE patients 3,16,17…”

Section: Introductionmentioning

confidence: 99%

The Role of Apoptosis Proteins and Complement Components in the Etiopathogenesis of Systemic Lupus Erythematosus

Liphaus

Kiss

2010

Clinics

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Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is a consensus that accelerated apoptosis of circulating lymphocytes and/or impaired clearance of apoptotic bodies may increase the amount of nuclear antigens presented to T lymphocytes. This process is accompanied by autoimmune responses that can lead to the development of lupus. The dysfunction of apoptosis may be a direct consequence of alterations in proteins/genes such as Fas, Bcl-2 and C1q. Increased expression of Fas antigen could intensify the exposure of hidden antigens. The overexpression of Bcl-2 protein might inhibit the removal of auto-reactive cells, and the lack of C1q could impair the clearance of self-antigens. The complete knowledge of the role of apoptosis components in the etiopathogenesis of lupus could lead to the development of new therapies targeting the apoptotic threshold, which could result in a more specific and effective disease response compared to global immunosuppression. This review summarizes the role of each component of the apoptotic process in the pathogenesis of lupus.

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“…Genetic factors are likely to be important both in determining the overall susceptibility to SLE and influencing the remarkable clinical heterogeneity of disease presentation and autoantibody production observed in affected subjects (2). Human leukocyte antigen (HLA) DRB1*02 and the allelic variant DRB1*15 have been associated with SLE in blacks and Asians and HLA-DRB1*03 has been associated with lupus in Caucasians, but clear associations with HLA and SLE could not be demonstrated in racially mixed populations (2)(3)(4)(5). It is recognized that certain HLA alleles show stronger association with autoantibody repertories and clinical subsets than with SLE itself.…”

Section: Introductionmentioning

confidence: 99%

HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations

Liphaus

Kiss

Goldberg

2007

Braz J Med Biol Res

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Human leukocyte antigens (HLA) DRB1*03 and DRB1*02 have been associated with systemic lupus erythematosus (SLE) in Caucasians and black populations. It has been observed that certain HLA alleles show stronger associations with SLE autoantibodies and clinical subsets, although they have rarely been associated with lupus renal histologic class. In the present study, HLA-DRB1 allele correlations with clinical features, autoantibodies and renal histologic class were analyzed in a cohort of racially mixed Brazilian patients with juvenileonset SLE. HLA-DRB1 typing was carried out by polymerase chain reaction amplification with sequence-specific primers using genomic DNA from 55 children and adolescents fulfilling at least four of the American College of Rheumatology criteria for SLE. Significance was determined by the chi-square test applied to 2 x 2 tables. The HLA-DRB1*15 allele was most frequent in patients with renal, musculoskeletal, cutaneous, hematologic, cardiac, and neuropsychiatric involvement, as well as in patients positive for anti-dsDNA, anti-Sm, anti-U1-RNP, and anti-SSA/Ro antibodies, although an association between HLA alleles and SLE clinical features and autoantibodies could not be observed. The HLA-DRB1*17, HLA-

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Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus

Abstract: In this group of children and adolescents with a high degree of racial admixture, we could not verify a significant association between human leukocyte antigens class II-DR and systemic lupus erythematosus.

Cited by 14 publications

References 24 publications

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The Role of Apoptosis Proteins and Complement Components in the Etiopathogenesis of Systemic Lupus Erythematosus

HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations

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