Necrolytic migratory erythema associated with glucagonoma syndrome: a case report

The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trélat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis.

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“…26 NME and weight loss are the most prevalent symptoms of glucagonoma, which can occur in about 65 -70% of patients. 23,27 …”

Section: Necrolytic Migratory Erythemamentioning

confidence: 99%

“…6 Rare cases of association between NME and non-glucagon-secreting tumors have been reported, leading to pseudoglucagonoma syndrome, such as small-cell lung cancer, liver cancer, insulin-secreting tumors and duodenal neoplasms. 9,27 …”

Section: Necrolytic Migratory Erythemamentioning

confidence: 99%

Paraneoplastic cutaneous manifestations: concepts and updates*

Silva

Mesquita

Igreja

et al. 2013

An. Bras. Dermatol.

144

170

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“…Glucagonoma syndrome caused by glucagon-secreting pancreatic tumor was first described by Becker et al in 1942 [ 3 ]. NME, the hallmark of this syndrome, is characterized by pruritic or painful erythematous well-demarcated plaques or patches with irregular edges, predominantly distributed in areas of increased friction and pressure [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Pseudoglucagonoma Syndrome Following Frey’s Surgery: A Case Report of a Rare Presentation

Wahab

2024

Cureus

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Pseudoglucagonoma syndrome is defined as the presence of necrolytic migratory erythema in the absence of a glucagon-secreting tumor. Necrolytic migratory erythema is the hallmark of glucagonoma syndrome but can also occur due to pancreatitis, pancreatic insufficiency, gastrointestinal dysfunction, inflammatory bowel disease, celiac disease, malabsorption disorders, nutritional deficiencies, hepatocellular dysfunction, and hypoalbuminemia. Pseudoglucagonoma syndrome is extremely rare, and the diagnosis is often delayed, resulting in delayed treatment. We report a rare case of pseudoglucagonoma syndrome in a malnourished male patient following Frey’s surgery. The patient presented with a skin rash which gradually progressed over 20 days with diffuse hair loss. On cutaneous examination, multiple irregular erythematous and eroded plaques surrounded by a hyperpigmented scaly border were present over the dorsal aspect of the lower limbs, upper limbs, gluteal region, and genitals. Routine investigations showed normocytic normochromic anemia, neutropenia, lymphocytosis, dyslipidemia, and hypoalbuminemia. Rapid resolution of the skin lesions was observed with improved nutrition.

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“…NME, glukagonoma ya da glukagon salgılayan tümörler için patognomonik kabul edilmekle beraber karaciğer hastalığı, malabsorbsiyon bozuklukları, adacık dışı hücre tümörlerinde de bildirilmiştir 42 . NME'ye eşlik eden diğer maligniteler psödoglukagonoma sendromuna yol açan tümörler olup küçük hücreli akciğer kanseri, karaciğer kanseri, insülin sekresyonu yapan tümörler ve duodenal neoplazmlardır [43][44] . Döküntü sıklıkla perioral ya da inguinal alandan başlar.…”

Section: Eritem Anüler Santrifüjunclassified

Paraneoplastik özellik gösteren reaktif dermatozlar

Ekinci¹,

Aslan²

2013

TURKDERM

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ÖzetReaktif dermatozlar infeksiyonlar, inflamatuar hastalıklar, ilaç kullanımı ve maligniteler başta olmak üzere birçok nedenle ortaya çıkabilirler. Böyle bir dermatozla karşılaşan hekimler dermatozu tedavi etmenin yanı sıra altta yatan nedeni araştırmaya da yönelirler. Bu derlemede, reaktif dermatozların paraneoplastik potansiyelleri değerlendirilerek tanı sonrası etyoloji, takip ve tedavide yapılması gerekenler irdelenmiştir. Sum maryReactive dermatoses may occur related to many underlying causes including infections, inflammatory diseases, medications and malignancies. In the management of these dermatoses the investigation of underlying cause is crucial besides the therapy of dermatosis. In this review, mainly the paraneoplastic potentials of reactive dermatoses have been evaluated and additionally the etiology, follow-up and treatment have been discussed. Recent literature about figurated erythemas (erythema annulare centrifugum, erythema gyratum repens, necrolytic migratory erythema), neutrophilic dermatoses (Sweet's syndrome, pyoderma gangrenosum, subcorneal pustular dermatosis) and erythema nodosum have been scrutinized. (Turkderm 2013; 47: Suppl 2: 69-77) Key Words: Paraneoplasia, reactive dermatoses, Sweet syndrome, erythema gyratum repens, necrolytic migratory erythema, erythema annulare centrifugum, subcorneal pustular dermatosis, erythema nodosum, pyoderma gangrenosum

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Necrolytic migratory erythema associated with glucagonoma syndrome: a case report

Cited by 6 publications

References 27 publications

Paraneoplastic cutaneous manifestations: concepts and updates*

Paraneoplastic cutaneous manifestations: concepts and updates*

Pseudoglucagonoma Syndrome Following Frey’s Surgery: A Case Report of a Rare Presentation

Paraneoplastik özellik gösteren reaktif dermatozlar

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