Widespread hematogenous metastases and Trousseau's syndrome in gastric adenocarcinoma

Santos, Vitorino Modesto dos; Rodrigues, Denise Bertulucci Rocha; Castro, Eumênia Costa da Cunha; Saldanha, João Carlos; Soares, Sheila; Teixeira, Vicente de Paula Antunes; Reis, Marlene Antônia dos

doi:10.1590/s0041-87812001000300005

Cited by 7 publications

(8 citation statements)

References 9 publications

(26 reference statements)

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“…Moreover, thrombocytosis, which is often detected in cancer patients, is a poor prognostic factor in stomach, ovary, breast and colon cancer (Pasquini et al ., 1995, Santos et al ., 2001). Platelets contribute to different stages of cancer progression such as angiogenesis, invasion, survival in circulation and metastasis (Gupta and Massagué, 2004; Jurasz et al ., 2004).…”

Section: Introductionmentioning

confidence: 99%

Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance

Radziwon‐Balicka

Medina

O’Driscoll

et al. 2012

British J Pharmacology

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BACKGROUND AND PURPOSECancer cells grow without the restraints of feedback control mechanisms, leading to increased cancer cell survival. The treatment of cancer is often complicated by the lack of response to chemotherapy leading to chemoresistance and persistent survival of tumour cells. In this work we studied the role of platelets in chemotherapy-induced cancer cell death and survival. EXPERIMENTAL APPROACHHuman adenocarcinoma cells, colonic (Caco-2) and ovarian (59 M) cells, were incubated with 5-fluorouracil (1-300 mg·mL ) for 1, 24 or 72 h. Following incubation, cancer cells were harvested and cell survival/death was assayed using flow cytometry, Western blotting, real-time PCR, TaqMan® Gene Expression Assays and proteomics. KEY RESULTSHuman platelets increased the survival of colonic and ovarian adenocarcinoma cells treated with two standard anticancer drugs, 5-fluorouracil and paclitaxel. In the presence of platelets, cancer cells up-regulated anti-apoptotic and down-regulated pro-apoptotic genes, increased the number of cells in the synthesis of DNA and decreased the number in the quiescent phase, increased expression of cyclins, DNA repair proteins and MAPKs. The analysis of platelet-Caco-2 secretome demonstrated the release of the chemokine RANTES, thrombospondin-1, TGF-b and clusterin. Finally, human recombinant RANTES and thrombospondin-1 improved survival of Caco-2 cells challenged with paclitaxel. CONCLUSIONS AND IMPLICATIONSThese data demonstrate that platelets increase adenocarcinoma cells survival, proliferation and chemoresistance to standard anticancer drugs. Modulating cancer cell-platelet interactions may offer a new strategy to improve the efficacy of chemotherapy. Abbreviations59 M, human ovarian adenocarcinoma; 5-FU, 5-fluorouracil; Caco-2, human colonic adenocarcinoma; Chk1, checkpoint 1; CRL2014, human gingival fibroblasts; G0/G1, quiescent/interphase G1 phases; G2/M, interphase G2/mitosis phases; PI, propidium iodide; PLT, platelets; PLTR, platelets releasate; PTX, paclitaxel; S, synthesis phase; TCIPA, tumour cell-induced platelet aggregation; TSP-1, thrombospondin-1

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Section: Introductionmentioning

confidence: 99%

Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance

Radziwon‐Balicka

Medina

O’Driscoll

et al. 2012

British J Pharmacology

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“…migratory thrombophlebitis) is a well-described association of advanced malignancy - particularly of pancreatic and pulmonary tumours [2]. The mechanism of this paraneoplastic phenomenon is unknown but has been linked to the late stage of these tumours at presentation, which in all reported cases to date, has precluded any form of curative intervention in these patients [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Unexpected outcome from Trousseau syndrome

et al. 2011

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BackgroundUnprovoked superficial thrombophlebitis and subsequent venous thromboembolism are well-described albeit rare presenting features of advanced visceral malignancy that often manifest too late for curative intervention to be beneficial.Case PresentationWe present the first reported case of early gastric carcinoma presenting with these paraneoplastic phenomena in an otherwise healthy farmer. The early presentation allowed for a curative partial gastrectomy, which itself was complicated by the presence of a deep vein thrombosis extending into the inferior vena cava. Fortunately, stabilization of the clot allowed for surgery to proceed without the need for a caval filter. The patient was referred for adjuvant chemotherapy and has since made an excellent recovery.ConclusionsThis case provides new evidence for the presentation of superficial thrombophlebitis in early gastric carcinoma and the potential for curative surgery in such instances. A high index of suspicion and a prompt diagnostic workup are essential for timely planning and execution of surgery in these early albeit rare presentations.

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“…The intense thrombocytopenia and prolonged prothrombin time due to acute liver failure may have contributed to the gastrointestinal bleeding and hypovolemia. Since fibrin microthrombi were not found in more than three different organs 4 , the diagnosis of DIC was not established in this case in spite of thrombocytopenia and prolonged prothrombin time.…”

Section: -Discussionmentioning

confidence: 86%

“…If patient's clinical situation worsens rapidly, in detriment of the differential diagnosis, the occult tumor stands to be found through autopsy studies 4,11,12 . This 28-years-old white male with unsuspected gastric adenocarcinoma presented severe liver dys- Data from autopsy studies of thromboplastinlike producing tumors, indicate that the frequency of thromboses is mostly age-related and associated to disseminated bone metastases.…”

Section: -Discussionmentioning

confidence: 99%

“…These changes have been related to paraneoplastic phenomena or bone marrow metastases, and may be the earliest manifestations, preceding the diagnosis of cancer 2,4 . The Budd-Chiari's syndrome (BCS), characterized by abdominal pain, hepatomegaly, hepatic dysfunction and ascitis, has been associated with abdominal cancers producing mucin and followed by severe centrilobular congestion and necrosis due to thrombosis or sluggish hepatic venous outflow 5,6 .…”

Section: -Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Síndrome de budd-chiari e adenocarcinoma gástrico insuspeito

Santos¹,

Castro²,

Araujo³

et al. 2005

Medicina (Ribeirão Preto)

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Abstract:The Budd-Chiari syndrome has not been described in young patients with gastric cancer. A case of Budd-Chiari syndrome and carcinomatous lymphangitis is reported in a 28 years-old white man with unsuspected gastric cancer, presenting jaundice, hematemesis and dyspnea. Autopsy disclosed gastric adenocarcinoma invading vessels of the submucous and serous layers, with gastric and intestinal bleeding, liver and lung metastases. Multiple mixed (fibrin, platelets and tumor cells) microthrombi were observed in small pulmonary blood vessels, and both subpleural lymph vessels and lung interstitium contained metastatic tumor cells.

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Widespread hematogenous metastases and Trousseau's syndrome in gastric adenocarcinoma

Cited by 7 publications

References 9 publications

Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance

Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance

Unexpected outcome from Trousseau syndrome

Síndrome de budd-chiari e adenocarcinoma gástrico insuspeito

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