Urinary tract infection in full-term newborn infants: risk factor analysis

Abstract

SUMMARY:Objective: To analyze the correlation of risk factors to the occurrence of urinary tract infection in full-term newborn infants. Patients and methods: Retrospective study (1997) including full-term infants having a positive urine culture by bag specimen. Urine collection was based on: fever, weight loss > 10% of birth weight, nonspecific symptoms (feeding intolerance, failure to thrive, hypoactivity, debilitate suction, irritability), or renal and urinary tract malformations. In these cases, another urine culture by suprapubic bladder aspiration was collected to confirm the diagnosis. To compare and validate the risk factors in each group, the selected cases were divided into two groups: Group I -positive urine culture by bag specimen collection and negative urine culture by suprapubic aspiration, and Group II -positive urine culture by bag specimen collection and positive urine culture by suprapubic aspiration .Results: Sixty one infants were studied, Group I, n = 42 (68.9%) and Group II, n = 19 (31.1%). The selected risk factors (associated infectious diseases, use of broad-spectrum antibiotics, renal and urinary tract malformations, mechanical ventilation, parenteral nutrition and intravascular catheter) were more frequent in Group II (p<0.05). Through relative risk analysis, risk factors were, in decreasing importance: parenteral nutrition, intravascular catheter, associated infectious diseases, use of broad-spectrum antibiotics, mechanical ventilation, and renal and urinary tract malformations. Conclusion:The results showed that parenteral nutrition, intravascular catheter, and associated infectious diseases contributed to increase the frequency of neonatal urinary tract infection, and in the presence of more than one risk factor, the occurrence of urinary tract infection rose up to 11 times. DESCRIPTORS: Urinary tract infection. Risk factor. Newborn infant.

Urinary tract infection in preterm infants: the protective role of breastfeeding

“…The presence of a peripheral intravenous catheter on the day of infection was significantly associated with the development of UTI, which is in agreement with the findings of Falcao [8]. This probably represents the need for intravenous antibiotics rather than a true risk factor.…”

Urinary tract infection among neonatal sepsis of late-onset in Cipto Mangunkusumo Hospital

“…The use of broad spectrum antibiotics may change natural flora in the neonate, increasing the risk of infections by opportunistic microorganisms. 19 Neonatal UTI occurs through hematogenic spread or by ascending microorganisms through the urethral meatus. 1 In our study, one subject had the same microorganism found in blood and urine cultures (Klebsiella pneumoniae), while other six subjects with UTI had different microorganisms in both cultures.…”

Caracterização de Escherichia coli uropatogênicas isoladas de crianças com infecção urinária.

“…Algumas leveduras, principalmente Candida albicans, também podem causar infecção urinária (FALCÃO et al, 2000;HEILBERG;SCHOR, 2003).…”

“…Enterobacter ssp., 1 a 6% Klebsiella ssp., 1 a 20% Staphylococcus ssp, e 1 a 5% leveduras (FALCÃO et al, 2000;NETO et al, 2003;PIRES et al, 2007;POLETTO;REIS, 2005). Todavia, na Turquia foi demonstrado que a prevalência desses agentes etiológicos é menor do que 2% (ARSLAN et al, 2005;YÜKSEL et al, 2006).…”

“…No entanto, no caso de ITU nosocomiais, P. aeruginosa é em âmbito global o principal agente etiológico. E. coli, por sua vez, é a bactéria mais comumente isolada em ITU comunitária, sendo que dependendo da população estudada sua prevalência varia entre 55 a 90% (ANDERSON et al, 2004;ARSLAN et al, 2005;FALCÃO et al, 2000;FOXMAN, 2002;KANTOR et al, 1984;MCBEAN;RAJAMANI 2001;NETO et al, 2003;PIRES et al, 2007;POLETTO;REIS, 2005;SIEGMAN-IGRA et al, 2002;YAMAMOTO et al, 1995;YÜKSEL et al, 2006). Por exemplo, na Turquia, E. coli é o agente causador de 90% das ITU sem complicações e de 78% das ITU com complicações (ARSLAN et al, 2005).…”