Indicators of inflammation and cellular damage in chronic asymptomatic or oligosymptomatic alcoholics: correlation with alteration of bilirubin and hepatic and pancreatic enzymes

Borini, Paulo; Guimarães, Romeu Cardoso

doi:10.1590/s0041-87811999000200005

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…In alcoholics, these enzyme changes have been attributed to changes in skeletal muscles 42,43 . The association between smoking and alcoholism is very frequent 44,45 .…”

Section: Discussionmentioning

confidence: 99%

Female alcoholics: electrocardiographic changes and associated metabolic and electrolytic disorders

Borini¹,

Terrazas²,

Júnior³

et al. 2003

Arq. Bras. Cardiol.

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In men and women, abusive ingestion of alcohol is associated with arterial hypertension [1][2][3] , cardiac arrhythmias 4 , and cardiac muscle impairment with several structural and functional abnormalities [5][6][7][8] . Myocardial lesions are expected to occur when the daily alcohol consumption is greater than 80g for an approximate period of 10 years 9 . However, lower daily doses (around 60g) for longer periods (approximately 25 years) may cause dilated cardiomyopathy, arrhythmias, and cardiac hypertensive disease 5,10 . A subgroup of chronic alcoholics with a greater sensitivity to development of hepatopathy, probably due to genetic reasons, exists. As such, vulnerability to cardiac changes may also depend on constitutional predisposition 11 . The following mechanisms have been cited as participating in the physiopathogeny of heart disease due to alcohol: direct action of alcohol or its metabolites on the cardiac muscle causing inflammation and fibrosis 12 , macro-and microangiopathic changes 13,14 , electrolytic changes, participation of metabolic and nutritional factors 15,16 , and the toxic effect of the additives present in alcoholic beverages 17 . Deficiency in thiamin itself does not seem to be the cause of alcoholic cardiomyopathy 18 , because it is associated with low cardiac output and systemic vasoconstriction, while, in the cardiomyopathy of beriberi, an elevated cardiac output occurs with reduced peripheral vascular resistance 4 . The increasing prevalence of female alcoholism among us 19,20 will certainly be a serious public health problem in the near future because of the increase in morbidity and mortality resulting from abusive alcohol consumption. If the cardiovascular problems of male alcoholism have not been sufficiently studied in Brazil, even less has been done in regard to female alcoholism. Women have been reported to be more susceptible than men are to diseases related to chronic alcoholism, even when ingesting a lower amount of alcohol. The difference in susceptibility between the sexes has been related to different proportions of body water and fat 21 and different rates of alcohol metabolism 22 . Therefore, women would be more susceptible than men in regard to Objective -To identify the electrocardiographic changes and their associations with metabolic and electrolytic changes in female alcoholics. Methods -

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“…In alcoholics, these enzyme changes have been attributed to changes in skeletal muscles 42,43 . The association between smoking and alcoholism is very frequent 44,45 .…”

Section: Discussionmentioning

confidence: 99%

Female alcoholics: electrocardiographic changes and associated metabolic and electrolytic disorders

Borini¹,

Terrazas²,

Júnior³

et al. 2003

Arq. Bras. Cardiol.

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“…A amilase é uma enzima produzida no pâncreas e nas glândulas salivares e comumente encontra-se elevada nas pancreatites aguda e crônica de origem alcoólica 32 . No estudo anteriormente citado realizado com 30 pacientes em um hospital psiquiátrico observou-se hiperamilasemia em 20% dos indivíduos etilistas 33 .…”

Section: Figura 2 Distribuição Dos Valores De Fosfatase Alcalina Nosunclassified

“…Alcoólatras que apresentam tempo pequeno de consumo de álcool, considerado como dependência aguda, sofrem poucas alterações hepáticas devido à alta capacidade de regeneração do fígado 29 . Outra limitação observada neste estudo foi que o exercício físico realizado foi baseado em experimentos anteriores 33 , sendo o tempo inferior às oito semanas, descrito na literatura como tempo mínimo para o organismo se adaptar às alterações metabólicas e fisiológicas sofridas durante o tempo de treinamento. Todavia, caso o protocolo experimental de exercícios ultrapassasse duas semanas, a chance de regeneração hepática após o tratamento com álcool poderia prejudicar a análise das enzimas.…”

Section: Figura 2 Distribuição Dos Valores De Fosfatase Alcalina Nosunclassified

Consumo De Álcool E a Influência Do Exercício Físico Na Atividade Enzimática De Ratos Wistar

Righi

Carvalho

Ribeiro

et al. 2016

Rev Bras Med Esporte

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RESUMOIntrodução: Biomarcadores vem sendo utilizados para monitorar o uso do álcool e, atualmente, os mais sensíveis e específicos são enzimas hepáticas, por exemplo, gama glutamiltransferase (GGT), alanina aminotransferase (ALT), aspartato aminotransferase (AST) e fosfatase alcalina (ALP). Objetivo: Verificar, a partir da experimentação animal, as alterações provocadas pelo uso de álcool e pela prática de atividade física nas enzimas hepáticas e pancreáticas. Métodos: Vinte e quatro ratos da linhagem Wistar foram distribuídos aleatoriamente em grupos experimentais, alojados em gaiolas com ambiente controlado, divididos de acordo com os tratamentos recebidos. No tratamento inicial, foi administrado álcool aos grupos álcool sedentário (AS) e álcool exercitado (AE) e, ao final da quarta semana, iniciou-se o programa de treinamento físico em esteira com os grupos AE e controle exercitado (CE). A coleta de sangue foi realizada por punção cardíaca ao final de cada experimento. Na análise estatística, utilizou-se teste de análise de variância (ANOVA) seguido de teste de Tukey e teste de Kruskal-Wallis. Resultados: O grupo AS apresentou valores significativamente mais elevados de ALT e ALP quando comparado aos grupos CE e AE, respectivamente. Não foram observadas diferenças significativas entre os quatro grupos estudados para os parâmetros AST, GGT e amilase. Conclusão: A associação entre consumo de álcool e sedentarismo aumentou a liberação das enzimas ALT e ALP em ratos Wistar; a prática de exercício físico aeróbico após abstinência alcoólica evitou o aumento da liberação de ALP no plasma desses animais.Descritores: alcoolismo/enzimologia, atividade motora, ratos Wistar. ABSTRACT Introduction: Biomarkers have been used to monitor the use of alcohol and currently the most sensitive and specific are the liver enzymes, for example, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP

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“…[1] Contributing factors include inflammation, [2] induction of apoptosis, [3] DNA damage, [4,5] changes in protein turnover, [6,7] and increased lipid peroxidation via the excessive generation of reactive oxygen species (ROS). [8] Chronic ethanol administration can generate hydroxyl radicals through P4502E1(CYP2E1) induction in liver, which ethanol-induced CYP2E1 was associated with the pathogenesis of alcoholic liver disease.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Ethanol Feeding on Oxysterols in Rat Liver

Ariyoshi¹,

Adachi²,

Asano³

et al. 2002

Free Radical Research

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It was our hypothesis that, as a consequence of increased oxidative stress, cholesterol-derived hydroperoxides and oxysterols are increased in livers of rats exposed to ethanol. To test this we dosed Wistar rats (approximately 0.1 kg initial body weight) with ethanol chronically (rats fed a nutritionally complete liquid diet containing ethanol as 35% of total calories; sampled liver at approximately 6-7 weeks). We measured concentrations of 7 alpha- and 7 beta-hydroperoxycholest-5-en-3 beta-ol (7 alpha-OOH and 7 beta-OOH) as well as 7 alpha- and 7 beta-hydroxycholesterol (7 alpha-OH and 7 beta-OH), and 3 beta-hydroxycholest-5-en-7-one (also termed 7-ketocholesterol; 7-keto). In response to chronic alcohol feeding, there were significant elevations in the concentrations of 7 alpha-OOH (+169%, P = 0.005) and 7 beta-OOH (+199%, P = 0.011). Increases in the concentrations of hepatic 7-keto (+74%, P = 0.01) and decreases in cholesterol (-43%; P = 0.03) also occurred. In contrast, the concentrations of both 7 alpha-OH and 7 beta-OH were not significant (NS). However, when oxysterols in chronic ethanol-fed rats were expressed relative to cholesterol there were significant increases in 7-keto/cholesterol (P = 0.0006), 7 alpha-OH/cholesterol (P = 0.0018) and 7 beta-OH/cholesterol (P = 0.0047). In conclusion, this is the first report of increased 7 alpha-OOH, 7 beta-OOH, and 7-keto in liver of rats and their elevation in chronic experimental alcoholism represent evidence of increased oxidative stress.

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Indicators of inflammation and cellular damage in chronic asymptomatic or oligosymptomatic alcoholics: correlation with alteration of bilirubin and hepatic and pancreatic enzymes

Cited by 7 publications

References 21 publications

Female alcoholics: electrocardiographic changes and associated metabolic and electrolytic disorders

Female alcoholics: electrocardiographic changes and associated metabolic and electrolytic disorders

Consumo De Álcool E a Influência Do Exercício Físico Na Atividade Enzimática De Ratos Wistar

Effect of Chronic Ethanol Feeding on Oxysterols in Rat Liver

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