Common variable immunodeficiency and isosporiasis: first report case

Silva, Gisele Barbosa e; Fernandes, Karla P.; Segundo, Gesmar Rodrigues Silva

doi:10.1590/s0037-86822012000600023

Cited by 8 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the setting of immunosuppression, diarrhea with malabsorption, dehydration, and weight loss is common. Symptoms may persist for months, and may be the presenting manifestation of underlying malignancy, HIV, or primary immunodeficiency [64-67]. In approximately 50% of patients a mild eosinophilia is seen over the course of illness [68, 69].…”

Section: Eosinophilia In the Short Term Travelermentioning

confidence: 99%

Eosinophilia in Infectious Diseases

O’Connell

Nutman

2015

Immunology and Allergy Clinics of North America

View full text Add to dashboard Cite

show abstract

Section: Eosinophilia In the Short Term Travelermentioning

confidence: 99%

Eosinophilia in Infectious Diseases

O’Connell

Nutman

2015

Immunology and Allergy Clinics of North America

View full text Add to dashboard Cite

show abstract

“…They may occur in a recurring basis and, thus, the patient has a much larger number of infections that the average for his age group, or may present more severe infections, with increased risk ( 8 ) . The patients with PIDs may also present with PIDs infections caused by unusual pathogens ( 9 ) . …”

Section: Discussionmentioning

confidence: 99%

“…Podem ocorrer de forma recorrente e, assim, o paciente apresenta um número muito maior de infecções que o habitualmente encontrado para sua faixa etária, ou podem ser mais graves, com risco acentuado à vida do paciente ( 8 ) . Os portadores de IDP podem ainda apresentar infecções causadas por patógenos não usuais ( 9 ) . …”

Section: Discussionunclassified

Primary immunodeficiency investigation in patients during and after hospitalization in a pediatric Intensive Care Unit

Suavinho¹,

Nápolis²,

Segundo³

2014

Rev. paul. pediatr.

View full text Add to dashboard Cite

Objective: To analyze whether the patients with severe infections, admitted in the Pediatric Intensive Care Unit of the Hospital de Clínicas of the Universidade Federal de Uberlândia, underwent the active screening for primary immunodeficiencies (PID). Methods: Retrospective study that assessed the data records of patients with any severe infections admitted in the Pediatric Intensive Care Unit, covering a period from January 2011 to January 2012, in order to confirm if they performed an initial investigation for PID with blood count and immunoglobulin dosage. Results: In the studied period, 53 children were hospitalized with severe infections in the Pediatric Intensive Care Unit, and only in seven (13.2%) the initial investigation of PID was performed. Among these patients, 3/7 (42.8%) showed quantitative alterations in immunoglobulin G (IgG) levels, 1/7 (14.3%) had the diagnosis of cyclic neutropenia, and 1/7 (14.3%) presented thrombocytopenia and a final diagnosis of Wiskott-Aldrich syndrome. Therefore, the PID diagnosis was confirmed in 5/7 (71.4%) of the patients. Conclusions: The investigation of PID in patients with severe infections has not been routinely performed in the Pediatric Intensive Care Unit. Our findings suggest the necessity of performing PID investigation in this group of patients.

show abstract

“…Gastrointestinal disturbances are common in CVID, with diarrhoea being the most common symptom reported [62][63][64][65][66][67][68]. Common causes include enteropathogens such as Giardia, Salmonella, Campylobacter and Cryptosporidium, with a variety of case reports of other common or unusual organisms [63,66,67,[69][70][71]. However, a range of inflammatory gastrointestinal pathologies are described [63,72].…”

Section: Common Variable Immunodeficiency (Cvid) Enteropathymentioning

confidence: 99%

Chronic norovirus infection and common variable immunodeficiency

Woodward

Gkrania‐Klotsas

Kumararatne

2016

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryChronic infection with norovirus is emerging as a significant risk for patients with immunodeficiency -either primary or secondary to therapeutic immunosuppression. Patients with primary immunodeficiency present a range of pathological responses to norovirus infection. Asymptomatic infections occur and differentiating viral carriage or prolonged viral shedding after self-limiting infection from infection causing protracted diarrhoea can be challenging, due to relatively mild pathological changes that may mimic other causes of diarrhoea in such patients (for instance pathogenic bacteria or parasites or graft-versus-host disease). However, a subset of patients with common variable immunodeficiency (CVID) experience a severe norovirus-associated enteropathy leading to intestinal villous atrophy and malabsorption. Symptomatic infection of up to 8 years has been demonstrated with clinical and histological recovery on viral clearance. Although oral immunoglobulins and nitazoxanide have been used to treat noroviral infections associated with immunosuppression, ribavirin is the only agent to date that has been linked to viral clearance in the Noroviral enteropathy associated with CVID.

show abstract

Common variable immunodeficiency and isosporiasis: first report case

Cited by 8 publications

References 7 publications

Eosinophilia in Infectious Diseases

Eosinophilia in Infectious Diseases

Primary immunodeficiency investigation in patients during and after hospitalization in a pediatric Intensive Care Unit

Chronic norovirus infection and common variable immunodeficiency

Contact Info

Product

Resources

About