Prevalence of Chagas disease in blood donors at the Uberaba Regional Blood Center, Brazil, from 1995 to 2009

Abstract

Introduction: A retrospective study was conducted to assess the occurrence of blood donations that were ineligible due to Chagas disease infection� from 1995 to 2009 at the Uberaba Regional Blood Center (HRU), Brazil, verify the tendency of this ineligibility, and describe the epidemiologic profile of the donors. Methods: Retrospective studies of serological ineligibility due to Chagas disease, statistical analysis by means of the chi-square test and odds ratio, study of the tendencies using a dispersion graph and the linear correlation coefficient (r) were performed. Results: In the period under study, a 0.2% serum prevalence of ineligibility due to Chagas disease was found, with a significant drop in ineligible donations from 2001 to 2009. Among the serum positive-donors, there was a significant predominance among those aged 30 years or above and non-single individuals. Conclusions: The results show a rate of occurrence that is lower than that described in literature, as well as a progressive drop during the 15 years under assessment. Such results are a consequence of systematic combat of the vector since the 70s and the progressive and consistent increase of returning donors, resulting in a drop of the contamination risk factor by means of blood transfusion and in the improvement of the quality of hemotherapy practices in the HRU.

Prevalence of Trypanosoma Cruzi antibodies in blood donors from the Sao Paulo State, Brazil, between 2012 and 2014

“…The obtained prevalence was similar to the seroprevalence registered in the city of Uberaba (0.2% serology without confirmation) [9]; however, it was higher compared to the cities of São Paulo (0.02% per year; study period 1996-2001) [10] and Campinas (0.05%) [11]. The last two cities, which are located within São Paulo State, represent the largest metropolitan territories not only in the State but also in the country; therefore, the anti-T. cruzi Ab seroprevalence is calculated on large sample volume with a smaller number of confirmed cases.…”

Prevalência da doença de Chagas entre doadores de sangue do Estado do Piauí, Brasil, no período de 2004 a 2013

“…Os demais estudos referem-se à prevalência da doença entre doações, variando no Brasil entre 0,1 e 0,3%, segundo os trabalhos mais recentes 11,12,13,14,15,16 . O relatório de produção hemoterápica brasileira, com dados de 2013, indica 0,34% de doações reagentes para a doença de Chagas na triagem entre os doadores, com os maiores percentuais (0,5%) no Nordeste e Sudeste 17 .…”

“…Em relação às características dos doadores, ao comparar o achado de maior prevalência entre o sexo masculino, observamos variação na literatura, dependendo da área e ano do estudo 9,13 . Quanto à maior prevalência de indivíduos com data de nascimento anterior a 1960, semelhante ao identificado em outros estudos 9,11,13 , pode estar relacionada às ações de controle vetorial, mais intensas a partir da década de 1980 3,11 . Infelizmente, a segunda maior prevalência foi identificada entre os indivíduos com data de nascimento após 1991, necessitando investigações para compreender o que está ocorrendo.…”

Prevalence of Trypanosoma cruzi infection in blood donors in El Salvador between 2001 and 2011

“…It is well known that significant decreases in T. cruzi seroprevalence and mortality due to Chagas disease resulted from the implementation of vector control programs in the Southern Cone region [27][28][29][30]. Similarly, the operation of a strong national malaria control program in El Salvador since the 1970s, which has resulted in a decrease in the number of malaria cases (last recorded as 15 per year in 2011) [31], might have contributed to a reduction in R. prolixus infection as a secondary positive effect.…”