Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels

Pace, Fábio Heleno de Lima; Ferreira, Lincoln Eduardo Vieira de Castro; Silva, Antônio Eduardo Benedito; Ferraz, Maria Lúcia Cardoso Gomes

doi:10.1590/s0037-86822012000400005

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…Viral hepatitis is the leading cause of morbidity and mortality among HIV-infected patients. The progression rate of hepatic fibrosis in co-infected patients is about twice as fast as in patients infected only with B or D virus [16].…”

Section: Discussionmentioning

confidence: 96%

Clinical and Epidemiological Profile of Cirrhotic Patients at a Reference Center in Belém-PA, Analysis of 10 years

Miranda¹,

Santos

Marinho³

et al. 2018

int arch med

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Background: The aim of this study was to analyze the demographic, ethyological and clinical aspects of patients with liver cirrhosis treated in the Chronic Liver Disease Center. Methods: a descriptive, cross-sectional and retrospective study based on the analysis of 580 pacients’ medical records with the diagnosis of hepatic cirrhosis treated from 2004 to 2014 in Belém, Brazil. Conclusions: the profile was predominantly of male patients, aged between 51 and 60 years, coming from the capital Belem, whose main etiologies of cirrhosis were C hepatitis and alcohol. Ascites was the most frequent clinical manifestation and Child-Pugh score A was the most prevalent.

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Section: Discussionmentioning

confidence: 96%

Clinical and Epidemiological Profile of Cirrhotic Patients at a Reference Center in Belém-PA, Analysis of 10 years

Miranda¹,

Santos

Marinho³

et al. 2018

int arch med

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“…Other authors have also made this observation. 5,6,10,14,24,32,33 Elevated levels of these enzymes may reflect hepatic inflammatory activity and higher activation of fibrogenesis. 34 To limit the staging error in our study, the slides were read ''blindly'' by 2 experienced pathologists, including only tissues with more than 10 portal spaces.…”

Section: Discussionmentioning

confidence: 99%

Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C

Leite

Duarte

Mendes-Corrêa

2015

J Int Assoc Provid AIDS Care

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Several studies have demonstrated that HIV/hepatitis C virus (HCV)-coinfected patients experience more rapid fibrosis progression. In this study, to estimate the annual rate of direct liver fibrosis progression, we used analyses of paired biopsy samples from HIV/HCV-coinfected patients without prior treatment of hepatitis and assessed the possible association of fibrosis progression with certain clinical variables. We evaluated 30 HIV/HCV-coinfected patients, with no history of prior treatment of hepatitis C, who underwent paired liver biopsies. All patients were under antiretroviral therapy at first and second biopsies. The average annual progression rate was 0.13 fibrosis unit/year, with 36.7% of patients defined as progressors. Liver fibrosis progression was associated with alanine aminotransferase (ALT; P < .001) and aspartate aminotransferase (AST; P < .0340) levels over 3 times the upper limit of normal present at first biopsy. Elevated ALT and AST levels appear to be associated with more accelerated liver fibrosis progression among HIV/HCV-coinfected patients.

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“…Another study reported 26% of persistent normal aminotransferase levels among the coinfected patients with HCV 13 . There is variation in the natural history of chronic hepatitis C; and majority of the patients are not likely to develop liver cirrhosis if proper treatment is administrated.…”

Section: Reactivation Of Virusmentioning

confidence: 97%

“…There is variation in the natural history of chronic hepatitis C; and majority of the patients are not likely to develop liver cirrhosis if proper treatment is administrated. However, the progression of liver disease occurs over several decades; and the rate of progression is increased due to steatosis, alcohol consumption, old age, insulin resistance, and other coinfections 13 .…”

Section: Reactivation Of Virusmentioning

confidence: 99%

Liver Enzymes Correlation among Chronic Hepatitis C Patients with Virus Infection Fibrosis Progression

et al. 2018

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Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels

Abstract: HCV-HIV coinfected patients with persistently normal ALTs showed slower progression of liver fibrosis. In these patients the development of liver cirrhosis is improbable.

Cited by 5 publications

References 35 publications

Clinical and Epidemiological Profile of Cirrhotic Patients at a Reference Center in Belém-PA, Analysis of 10 years

Clinical and Epidemiological Profile of Cirrhotic Patients at a Reference Center in Belém-PA, Analysis of 10 years

Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C

Liver Enzymes Correlation among Chronic Hepatitis C Patients with Virus Infection Fibrosis Progression

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