Neurocysticercosis: a new trend in SUDEP research?

Arida, Ricardo Mário; Mendonça, Philipe Ribeiro Furtado de; Cavalheiro, Ésper A.; Leite, João Pereira

doi:10.1590/s0037-86822012000200032

Cited by 1 publication

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References 11 publications

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“…21,22 Patients with generalized seizures may present with sudden unexpected death in epilepsy. 23,24 In the subarachnoid NCC group, intracranial hypertension may lead to death if not treated promptly. Sudden death in a patient with hydrocephalus with no history of epilepsy has been reported.…”

Section: Discussionmentioning

confidence: 99%

Mortality in Parenchymal and Subarachnoid Neurocysticercosis

Abanto

Blanco²,

Saavedra

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Abstract.Neurocysticercosis (NCC) is endemic in many parts of the world, carrying significant neurological morbidity that varies according to whether lesions are located inside the cerebral parenchyma or in extraparenchymal spaces. The latter, in particular subarachnoid NCC, is assumed to be more severe, but no controlled studies comparing mortality between types of NCC exist. The aim of this study was to compare all-cause mortality between patients with intraparenchymal NCC and those with subarachnoid NCC. Vital status and sociodemographic characteristics were evaluated in patients with intraparenchymal viable, intraparenchymal calcified, and subarachnoid NCC attending a neurological referral hospital in Lima, Perú. Survival analyses using Kaplan–Meier curves and Cox proportional regression models were carried out to compare mortality rates between groups. From 840 NCC patients followed by a median time of 82.3 months, 42 (5.0%) died, six (1.8%) in the intraparenchymal viable group, four (1.3%) in the calcified group, and 32 (16.6%) in the subarachnoid group (P < 0.001). Older age and lower education were significantly associated with mortality. The age-adjusted hazard ratio for death in the subarachnoid group was 13.6 (95% CI: 5.6–33.0, P < 0.001) compared with the intraparenchymal viable group and 10.7 (95% CI: 3.7–30.8, P < 0.001) when compared with the calcified group. We concluded that subarachnoid disease is associated with a much higher mortality in NCC.

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