Severe coinfection of melioidosis and dengue fever in northeastern Brazil: first case report

Macedo, Rafael; Rocha, Felipe A; Rolim, Dionne Bezerra; Vilar, Dina Cortez Lima Feitosa; Araújo, Fernanda Montenegro de Carvalho; Vieira, Nélia Nogueira; Teixeira, Juliana Rodrigues; Carvalho, Maíza Colares; Oliveira, Francisco George Magalhães; Cavalcanti, Luciano Pamplona de Góes

doi:10.1590/s0037-86822012000100028

Cited by 8 publications

(4 citation statements)

References 9 publications

(8 reference statements)

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“…Several studies have demonstrated that it is difficult to differentially diagnose dengue from other pathologies (e.g., hantavirus, rubella, hepatitis, influenza A infection, or melioidosis), which may account for some of the cases of fever symptoms that were not diagnosed as leptospirosis in this study 17 , 18 , 25 . Those studies' findings highlight the importance of using surveillance protocols for fever syndromes, and the implementation of these systems in Brazil may facilitate the early detection of new diseases with similar clinical characteristics, such as chikungunya fever.…”

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confidence: 81%

A New Possibility for Surveillance: Do We Identify All Cases of Leptospirosis?

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Cavalcanti

Oliveira

et al. 2015

Rev. Inst. Med. trop. S. Paulo

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SUMMARYLeptospirosis is a febrile disease with a typically underestimated global incidence, especially in regions where dengue is endemic. Therefore, it is difficult to accurately determine the number of leptospirosis cases in these areas, which contributes to significant under-reporting this disease. In this study, we estimated the number of possible leptospirosis cases among dengue-like cases that were reported during 2008, 2010, and 2012 in the city of Fortaleza, northeast Brazil. Patients were evaluated for dengue and leptospirosis using immunoenzymatic tests for IgM antibodies that were specific to each pathogen. Among the suspected cases of dengue that resulted as negative in laboratory tests, 10.8% (2008), 19.2% (2010), and 30.8% (2012) were confirmed to be leptospirosis. Considering the cases reported by the surveillance authority as dengue that were subsequently discarded based on the laboratory test results, we estimate that the number of actual leptospirosis cases may be 26 to 49 times higher than those diagnosed and reported by the Health Services. Furthermore, we believe that approximately 20% of dengue-like cases may be leptospirosis cases in areas where the two diseases are endemic.

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confidence: 81%

A New Possibility for Surveillance: Do We Identify All Cases of Leptospirosis?

Fontes

Cavalcanti

Oliveira

et al. 2015

Rev. Inst. Med. trop. S. Paulo

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“…It has been unusual to detect B. pseudomallei with other pathogens in patients. Dengue and melioidosis coinfection was reported in Northeastern Brazil [ 10 ]; A case of leptospirosis and melioidosis co-infection occurred in Malaysia [ 11 ]. Melioidosis coinfection with other disease e.g.…”

Section: Introductionmentioning

confidence: 99%

First co-infection case of melioidosis and Japanese encephalitis in China

Chen³

et al. 2018

BMC Infect Dis

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BackgroundMelioidosis is endemic in Southeast Asia and northern Australia. Infection usually follows percutaneous inoculation or inhalation or ingestion of the causative bacterium, Burkholderia pseudomallei, which is present in soil and surface water in endemic regions. Japanese encephalitis (JE) is a vector-borne viral zoonosis caused by Japanese encephalitis virus (JEV), leading to epidemic encephalitis in Southeast Asia. Both B. pseudomallei and JEV have spread dominantly in the Hainan and Guangdong provinces in China. Here we reported the first case of co-infection of B. pseudomallei and JEV, which was discovered in Huizhou in the Guangdong province in June 2016.Case presentationA 52-year-old man was admitted to the hospital with acute febrile illness and headache, diagnosed as respiratory infection, central nervous system (CNS) infection, septicemia, and hepatic dysfunction. Based on B. pseudomallei-positive blood and cerebrospinal fluid (CSF) cultures, the patient was diagnosed with melioidosis and treated aggressively with antibiotics. However, the patient failed to make a full recovery. Further laboratory tests focused on CNS infection were conducted. The co-infection of B. pseudomallei and JEV was confirmed after the positive IgM antibodies of JEV were detected in both CSF and blood. After diagnosis of co-infection with B. pseudomallei and JEV, the patient was provided supportive care in hospital and recovered after approximately 3 weeks.ConclusionGiven the possibility of co-infection of B. pseudomallei and JEV, as well as variable case presentations, it is critical to enhance the awareness, detection, and treatment of co-infection in regard to melioidosis.

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“…Four siblings acquired acute infection after recreational exposure at the town dam and three of them died within a week [ 7 , 8 , 9 , 10 ]. By 2017, 30 cases had been diagnosed in Ceará [ 2 , 11 , 15 , 16 , 17 , 18 , 23 ]. Characterisation of clinical and environmental B. pseudomallei from Ceará showed that considerable genetic diversity is present [ 30 ].…”

Section: Review Of Published Melioidosis Cases and The Presence Ofmentioning

confidence: 99%

Melioidosis in South America

et al. 2018

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Melioidosis is an emerging disease in the Americas. This paper reviews confirmed cases, the presence of Burkholderia pseudomallei and the organization of national surveillance policies for melioidosis in South America. Confirmed cases in humans have been reported from Ecuador, Venezuela, Colombia, Brazil, and Peru. The bacterium has been isolated from the environment in Brazil and Peru. The state of Ceará, northeastern region of Brazil, is the only place where specific public strategies and policies for melioidosis have been developed. We also discuss the urgent need for health authorities in South America to pay greater attention to this disease, which has the potential to have a high impact on public health, and the importance of developing coordinated strategies amongst countries in this region.

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Severe coinfection of melioidosis and dengue fever in northeastern Brazil: first case report

Cited by 8 publications

References 9 publications

A New Possibility for Surveillance: Do We Identify All Cases of Leptospirosis?

A New Possibility for Surveillance: Do We Identify All Cases of Leptospirosis?

First co-infection case of melioidosis and Japanese encephalitis in China

Melioidosis in South America

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