Clinical and epidemiological profile of blood donors with positive serology for viral hepatitis in southern Brazil

Silveira, Luciana da; Schiavon, Leonardo de Lucca; Silva, Kerley Pereira da; Lopes, Thiago Barbieri; Zaccaron, Marcos da Rocha; Narciso-Schiavon, Janaína Luz

doi:10.1590/s0037-86822011005000028

Cited by 8 publications

(14 citation statements)

References 33 publications

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“…This result is inconsistent with the results of the Epidemiological Profi le of Brazilian Blood Donor study performed in 2004, which indicated a higher frequency of donations from donors between 30 and 39 years of age (28.3% in Brazil and 27% in Southern Brazil) 34 . In similar studies, the mean age of the donors was found to be between 36.5 ± 11.0 and 45.0 + 10.9 years 32,33 . This difference can be explained by the location of the blood bank at a university hospital and by the several blood donation campaigns promoted in every course, especially during the fi rst year of university study.…”

Section: Discussionmentioning

confidence: 70%

“…With respect to ethnicity, 96.2% of blood donors in the present study were Caucasian, which is consistent with the 2010 census in which 83.9% of the population of the State of Santa Catarina declared themselves as Caucasian 36 . In a similar study, the percentage of Caucasian blood donors in Southern Brazil was 99.2% 33 . The prevalence of single (79.2%) donors and donors who completed high (97.2%) school was greater than that found in previous studies (34.4-49.0% and 54.7-63.7%, respectively) 33,34 , possibly refl ecting the university population in this state.…”

Section: Discussionmentioning

confidence: 73%

“…In a similar study, the percentage of Caucasian blood donors in Southern Brazil was 99.2% 33 . The prevalence of single (79.2%) donors and donors who completed high (97.2%) school was greater than that found in previous studies (34.4-49.0% and 54.7-63.7%, respectively) 33,34 , possibly refl ecting the university population in this state.…”

Section: Discussionmentioning

confidence: 73%

“…Sharma et al 37 reported that when the donor group is composed of mostly student volunteers, a lower proportion of donors with positive serology is observed 37 . Other studies addressing the epidemiological characteristics of blood donors showed that the presence of serological markers increases with the age of the donor 33,38 . The prevalence of viral hepatitis markers in this study (HBsAg: 0.1%, anti-HBc: 2.1%, anti-HCV: 0.9%) was lower compared with that in countries of high endemicity and similar to levels observed in areas with a low prevalence of these infections.…”

Section: Discussionmentioning

confidence: 98%

“…Research on blood donors has shown a predominance of male donors, with a prevalence of 63.9-71.3% [32][33][34][35] . With respect to ethnicity, 96.2% of blood donors in the present study were Caucasian, which is consistent with the 2010 census in which 83.9% of the population of the State of Santa Catarina declared themselves as Caucasian 36 .…”

Section: Discussionmentioning

confidence: 99%

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Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Maccarini

Nazário

Ferreira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Despite the great advances in serological testing for transfusion-transmitted infections, the selection of blood donors by blood bank operators remains the only way to avoid transmission within the testing window period. Part of this selection is the self-exclusion form, on which the donors can exclude their blood from donation without any explanation. This study assessed the clinical and epidemiological characteristics related to positivity for viral hepatitis and to the use of the confi dential self-exclusion (CSE) form. Methods: This transversal study analyzed the data collected from blood donors' fi les in a hospital in Southern Brazil. Univariate and multivariate analyses identifi ed the clinical and epidemiological variables related to positive serologies of viral hepatitis and to whether the donor was self-excluded. Results: Of the 3,180 donors included in this study, 0.1% tested positive for HBsAg, 2.1% for anti-HBc, and 0.9% for anti-HCV. When the 93 donors with positive serologies for viral hepatitis were compared with those who were negative, a greater proportion of the positive serology group was found to have had a history of blood transfusions (OR=4.908; 95%CI=1.628 -14.799; p<0.01), had repeatedly donated (OR=2.147; 95%CI=1.236 -3.729; p<0.01), and used the CSE form for self-exclusion (OR=7.139; 95%CI=2.045 -24.923; p<0.01). No variables were independently associated with self-exclusion. Conclusions: A history of blood transfusion, repeated donations, and self-exclusion are factors that should be considered during viral hepatitis screenings in blood banks.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Maccarini

Nazário

Ferreira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Decrease in hepatitis B prevalence among blood donors in Central-West Brazil

Lindenberg

Motta-Castro

Puga

et al. 2013

Journal of Venomous Animals and Toxins including Tropical Disea

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BackgroundThe aim of the present study was to estimate hepatitis B virus seroprevalence among first-time blood donors in the city of Campo Grande, Mato Grosso do Sul State, in the central-western region of Brazil.FindingsA retrospective analysis of first-time voluntary blood donor records, from January 2010 to December 2010, was conducted at the Hematology Center of Mato Grosso do Sul. The prevalence of the HBsAg and anti-HBc serological markers and their respective 95% confidence intervals were calculated. Chi-square analysis was performed between the seroprevalence previously found in 2001 and the one determined by the current study. Results were considered statistically significant if p < 0.05. Among 8,840 subjects, 269 (3.04%, 95% CI: 2.7-3.4) were positive for HBV markers. The prevalence rate of HBsAg was 0.19% (95% CI: 0.1-0.3) and anti-HBc alone was 2.85% (95% CI: 2.5-3.2).ConclusionsThere was no statistically significant difference regarding gender. However, an important association was observed between HBV infection and older age (p < 0.01). The seroprevalence of HBV infection in first-time blood donors diminished from 2001 to 2010 (p < 0.01). Such decrease suggests an improvement in the recruitment of safe donors, the positive impact of vaccination programs and the decreasing of HBV infection prevalence in the general population.

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Prevalence and factors associated with HCV infection among elderly individuals in a southern Brazilian city

Martins

Machado

Schuelter-Trevisol

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Few Latin American studies have assessed the prevalence of hepatitis C virus (HCV) infection in elderly individuals, in whom the highest rates are expected. We aimed to investigate the prevalence of and factors associated with HCV infection in elderly residents in the municipality of Tubarão, Santa Catarina. Methods: This cross-sectional study included 820 individuals (aged ≥ 60 years) who were selected by simple random sampling. The presence of anti-HCV antibodies was tested by chemiluminescence, and HCV RNA detection was performed for the anti-HCV-reactive subjects. Those individuals who were anti-HCV reactive but had undetectable HCV RNA levels were tested using a third-generation recombinant immunoblot assay. The variables were compared using the chi-squared test or Fisher's exact test, and those variables with p < 0.05 were included in the logistic regression model. Results: The mean patient age was 68.6 years (SD 7.0 years); 39% were men, and 92% were Caucasian. Eighteen subjects were anti-HCV positive. Among these individuals, 4 were characterized as false-positives, leaving 14 (1.7%) individuals with confi rmed infections for analysis. HCV infection was associated with an age older than 65 years, households with 3 or more residents and the previous transfusion of blood products. In the logistic regression analysis, the following variables were independently associated with HCV infection: households with 3 or more residents (OR 7.9, 95% CI 1.7-35.9, p = 0.008) and previous blood transfusion (OR 6.2, 95% CI 2.1-18.6, p = 0.001). Conclusions: The HCV prevalence in the elderly population in the municipality of Tubarão was higher than that found in previous studies of blood donors in the same region. Although exposure to contaminated blood products remained important, other transmission routes, such as household transmission, could play a role in HCV infection.

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Clinical and epidemiological profile of blood donors with positive serology for viral hepatitis in southern Brazil

Abstract: Perfil clínico e epidemiológico de doadores de sangue com sorologias positivas para hepatites virais no sul do Brasil

Cited by 8 publications

References 33 publications

Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Decrease in hepatitis B prevalence among blood donors in Central-West Brazil

Prevalence and factors associated with HCV infection among elderly individuals in a southern Brazilian city

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