Pseudothrombocytopenia in schistosomiasis mansoni

Lambertucci, José Roberto; Duani, Helena; Prata, Pedro Henrique; Voieta, Izabela

doi:10.1590/s0037-86822011000600029

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Hepatosplenic patients with thrombocytopenia have diffi culty fi nding jobs because they are considered to be sick and cannot work, particularly when the job requires physical exercise 70,71 . Dentists do not treat their gingival problems or remove their teeth because they can bleed excessively.…”

Section: Thrombocytopeniamentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fi brosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fi brosis was made by abdominal palpation and the fi nding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fi brosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) fi ndings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fi brosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.

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Section: Thrombocytopeniamentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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“…The patient was diagnosed with pseudothrombocytopenia (an in vitro error) and was reallocated to the group with normal platelet counts. Pseudothrombocytopenia has been reported to occur in as many as 17% of patients who visit hematology units to seek a diagnosis for their thrombocytopenia [31][32][33][34][35][36] . We are planning a new study in rural areas of Brazil that are endemic for schistosomiasis to assess the frequency of pseudothrombocytopenia.…”

Section: Patients With Hss N=21mentioning

confidence: 99%

Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni

Drummond

Pereira

Otoni

et al. 2014

Rev. Soc. Bras. Med. Trop.

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EDTA-dependent pseudothrombocytopenia in patients with hepatosplenic schistosomiasis mansoni: a clinical management alert

Trindade

Pereira

Caporali

et al. 2021

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Hepatosplenic schistosomiasis mansoni (HS) is associated with thrombocytopenia. Accurate platelet counts are required for identification and management of HS patients. EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon of anticoagulant-activated platelet agglutination resulting in low platelet counts by automated methods. The prevalence of EDTA-PCTP in schistosomiasis is unknown and only one case has been described. Our aims were to determine the prevalence of EDTA-PTCP in HS and evaluate alternative methods to overcome this analytical error. Methods Blood samples from 56 HS patients and 56 healthy volunteers were collected, and platelet counts were obtained using standard microscopy and automated (electric impedance) methods. Automated platelet counts and the presence of platelet clumps in blood smears were evaluated in samples collected in EDTA or sodium citrate tubes 20 and 180 min after blood collection. Results EDTA-PTCP was more frequent in HS patients than healthy volunteers (8.92% vs 0.00%, p<0.0285). Platelet clumps and PTCP were also observed in samples collected in sodium citrate tubes, refuting its use as an alternative method. Conclusions Automated platelet counts in blood samples from HS patients should be performed right after blood collection in EDTA tubes and verified by manual counts in blood smears.

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Pseudothrombocytopenia in schistosomiasis mansoni

Cited by 4 publications

References 4 publications

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni

EDTA-dependent pseudothrombocytopenia in patients with hepatosplenic schistosomiasis mansoni: a clinical management alert

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