Occurrence of 102 cases of paracoccidioidomycosis in 18 months in the Itaipu Lake region, Western Paraná

Loth, Eduardo Alexandre; Castro, Solange Venturini de; Silva, Joseane Rodrigues da; Gandra, Rinaldo Ferreira

doi:10.1590/s0037-86822011000500023

Cited by 34 publications

(27 citation statements)

References 11 publications

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“…Estudios realizados en la zona de los lagos de la represa de Itaipú (incluye Alto Paraná), frontera Paraguay-Brasil, mostraron que la coinfección (PCM-tuberculosis) fue la causa asociada a óbitos más frecuente. Además, en este estudio, se observó un aumento importante en la prevalencia de la enfermedad en mujeres (18) . La construcción de la represa Yacyretá en el noreste de Argentina produjo cambios en el valle del río Paraná y tuvo un impacto en las tasas de infección de PCM entre los habitantes de la región, donde esta micosis era rara anteriormente (19) .…”

Section: Resultsunclassified

Paracoccidioidomicosis detectados en el período 2004-2013 en el Laboratorio Central de Salud Pública de Asunción - Paraguay

Araujo

Aguilar

Arce

et al. 2016

Rev. Nac. (Itauguá)

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Section: Resultsunclassified

Paracoccidioidomicosis detectados en el período 2004-2013 en el Laboratorio Central de Salud Pública de Asunción - Paraguay

Araujo

Aguilar

Arce

et al. 2016

Rev. Nac. (Itauguá)

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“…This mycosis is relatively uncommon in children, with approximately 5 % of all patients being less than 10 years of age. When children and adolescents (< 14 years old) are set together, approximately 15 % of all cases correspond to this age bracket, with 8 % more being less than 20 years of age [6,12,13,23,27,28]. PCM occurs most commonly in middle-aged men (40-60 years), with the exception of immunosuppressed patients who tend to be younger [6, 11-13, 29, 30].…”

Section: Epidemiologymentioning

confidence: 99%

“…Antibody detection has been based upon antigen preparations using either mycelial or yeast cell lysates. While a series of immunoreactive antigens (27,43,70, and 87 kDa) are present in these lysates, the predominant antigen is the 43 kDa glycoprotein, gp43 [76][77][78][79][80][81].Because of its simplicity, the gel immunodiffusion (ID) test is typically used in endemic countries. This test demonstrates circulating antibodies in 65-95 % of the cases and is highly specific.…”

Section: Immunodiagnostic Testsmentioning

confidence: 99%

Paracoccidioidomycosis

Restrepo

Orozco

Gómez

et al. 2015

Diagnosis and Treatment of Fungal Infections

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“…America that is caused by a thermo-dimorphic fungus, Paracoccidioides brasiliensis 1,2 . The fungi initially infect the lungs, but can also disseminate throughout the entire body [3][4][5] .…”

Section: Paracoccidioidomycosis (Pcm) Is a Disease Endemic In Latinmentioning

confidence: 99%

The influence of carbohydrates in the interaction of Paracoccidioides brasiliensis with CCL-6 cells in vitro

Silva

Pimenta

Silva

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction:Little is known about the early events in the interaction between Paracoccidioides brasiliensis and its host. To understand the effect of carbohydrates in the interaction between the fungus and epithelial cell in culture, we analyzed the influence of different carbohydrate solutions on the adhesion of P. brasiliensis yeast cells to CCL-6 cells in culture. Methods: Fungal cells were cultivated with the epithelial cell line, and different concentrations of D-fucose, N-acetyl-glucosamine, D-mannose, D-glucosamine, D-galactosamine, sorbitol and fructose were added at the beginning of the experiment. Six hours after the treatment, the cells were fixed and observed by light microscopy. The number of P. brasiliensis cells that were adhered to the CCL-6 monolayer was estimated. Results: The number of adhesion events was diminished following treatments with D-fucose, N-acetyl-glucosamine, D-mannose, D-glucosamine and D-galactosamine as compared to the untreated controls. Sorbitol and fructose-treated cells had the same adhesion behavior as the observed in the control. P. brasiliensis propagules were treated with fluorescent lectins. The FITC-labeled lectins WGA and Con-A bound to P. brasiliensis yeast cells, while SBA and PNA did not. Conclusions: The perceptual of adhesion between P. brasiliensis and CCL-6 cells decreased with the use of D-mannose, N-acetyl-glucosamine and D-glucosamine. The assay using FITC-labeled lectins suggests the presence of N-acetyl-glucosamine, α-mannose and α-glucose on the P. brasiliensis cell surface. An enhanced knowledge of the mediators of adhesion on P. brasiliensis could be useful in the future for the development of more efficient and less harmful methods for disease treatment and control.

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Occurrence of 102 cases of paracoccidioidomycosis in 18 months in the Itaipu Lake region, Western Paraná

Abstract: Revista da Sociedade Brasileira de Medicina Tropical 44(5):636-637, set-out, 2011Occurrence of 102 cases of paracoccidioidomycosis in 18 months in the Itaipu Lake region, western Paraná

Cited by 34 publications

References 11 publications

Paracoccidioidomicosis detectados en el período 2004-2013 en el Laboratorio Central de Salud Pública de Asunción - Paraguay

Paracoccidioidomicosis detectados en el período 2004-2013 en el Laboratorio Central de Salud Pública de Asunción - Paraguay

Paracoccidioidomycosis

The influence of carbohydrates in the interaction of Paracoccidioides brasiliensis with CCL-6 cells in vitro

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