Immunohistochemical expression of oestrogen and progesterone receptors during experimental acute and chronic murine Schistosomiasis mansoni

Habib, Fawzia; Zaki, M.M.; El-Aal, Amany Ahmed Abd; Safwat, Maha; Domiaty, Magda Ahmed El

doi:10.1590/s0037-86822010000500012

Cited by 4 publications

(3 citation statements)

References 15 publications

(11 reference statements)

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“…The hormonal microenvironment also modulates gene expression of female and male S. mansoni adult parasites [9]. At present, there are very few reports associating infertility with S. mansoni infection, and in general, it is caused by the presence of egg and the formation of granuloma in reproductive organs [10][11][12][13]. Few works described a relation of S. mansoni infection and hormonal changes, such as it has been explored in S. haematobium [13].…”

Section: Introductionmentioning

confidence: 99%

Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

Oliveira

Cardoso

Santos

et al. 2019

EMIDDT

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Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.

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Section: Introductionmentioning

confidence: 99%

Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

Oliveira

Cardoso

Santos

et al. 2019

EMIDDT

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“…S. mansoni is also likely to cause infertility in women, although there are very few reports in the literature. In fact there are only two reports describing an ectopic location of S. mansoni eggs in the endocervix [32] and in the endometrium and ovary [33], and another two reports describing hormonal imbalance in female mice infected with S. mansoni [34,35]. Hormonal disturbances may also explain female infertility and subfecundity associated with S. mansoni infection (Table 1) [2,5,26].…”

Section: Mechanisms Underlying Female and Male Infertility-associatedmentioning

confidence: 99%

Schistosomiasis and Infertility: What Do We Know?

Ribeiro

Luís

Fernandes

et al. 2019

Trends in Parasitology

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There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis. Schistosomiasis and Infertility Infertility is defined as the incapacity to become pregnant after 12 months of regular and unprotected intercourse. This is a major public health problem that affects about one in six couples (15-20%) worldwide and 12-30% of couples in sub-Saharan Africa [1-3]. It is well recognized as a major sequela of genital tract infection; many women in Africa with this ailment (85-90%) suffer from subsequent infertility, and the cause can be attributed to pelvic infections [4]. Numerous diseases, including febrile diseases, sexually transmitted infections (STDs), and various parasitic infections, such as microfilaria and schistosomiasis, can cause infertility [5]. When considering the diagnosis of infertility there are two main features of this disease: primary infertility, considered when the woman never conceived, and secondary infertility when she had had a previous labor [5]. Most articles addressing infertility-associated schistosomiasis describe only primary infertility, and we found only two reports in the literature describing secondary infertility: one from our group [5] and one from another group [6], both reporting a lack of association between secondary infertility and schistosomiasis.

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“…These systems are connected by a complex network in which the immune response of the host to the parasite is modulated by many hormones (Hernández-Bello et al, 2010). Habib et al (2010) reported a relation between schistosomiasis and hormonal changes. Delmondes et al (2014) found an association between schistosomiasis and infertility, which occurred due to formation of egg granuloma in reproductive organs.…”

Section: Introductionmentioning

confidence: 99%