Epidemiology of extended spectrum β-lactamase producing Enterobacter bacteremia in a brazilian hospital

Abstract

Introduction: Enterobacter can be included in the group of extended spectrum β-lactamases (EBSL)-producing bacteria, though few studies exist evaluating risk factors associated with this microorganism. A retrospective cohort study was conducted to determine risk factors associated with ESBL-producing-Enterobacter and mortality. Methods: A retrospective cohort study with 58 bacteremia caused by ESBL-producing-Enterobacter (28 cases) and non-ESBL (30 cases). Results: Risk factors associated with ESBL-Enterobacter were trauma, length of hospitalization, admission to the intensive care unit, urinary catheter and elective surgery (p< 0.05). The survival curves were similar for ESBL and non-ESBL. Conclusions: ESBLproducing-Enterobacter bacteremia is prevalent and the survival curve was similar to non-ESBL-producing strains.

Epidemiologia das betalactamases de espectro estendido no Brasil: impacto clínico e implicações para o agronegócio

“…Em relação à família Enterobacteriaceae, o isolamento de ESBL é descrito em diversos patógenos de origem hospitalar e comunitária, inserindo Klebsiella spp., Escherichia coli, Salmonella enterica, Citrobacter spp., Enterobacter spp., Proteus mirabilis e Serratia marcescensi (9,16,18,20,24,52,59,85) . Contudo, o ponto de urgência clínica tem sido a alta prevalência de ESBL em Klebsiella spp.…”

KPC-producing Enterobacter aerogenes infection

“…However, we have observed a progressive decrease in susceptibility to fourth generation cephalosporin, suggesting increase of ESBL-producing strains. 1 ESBL-producing Enterobacter are usually susceptible only to carbapenems, and these drugs have been the treatment of choice for severe infections. More recently, the emergence of carbapenemase-producing Enterobacteriaceae has severely challenged antimicrobial therapy, since it confers a distinct level of resistance to carbapenems.…”

Predictive factors of post-discharge surgical site infections among patients from a teaching hospital

“…Surgical site infections (SSIs) pose a special threat to those patients, leading to the increased use of antimicrobials, prolonged hospitalizations, permanent sequelae or even death. SSIs have also been associated with the acquisition of multidrug-resistant organisms 1 . Although there are no data on the overall SSI incidence in Brazil, the Program for Surveillance of Healthcare Associated Infections in the State of São Paulo (PSHAISP) reported median rates of approximately 0.6% for clean wound procedures from 546 hospitals 2 .…”