Síndrome pulmonar e cardiovascular por hantavírus: aspectos clínicos de uma doença emergente no sudeste brasileiro

Borges, Alessandra Abel; Badra, Soraya Jabur; Figueiredo, Glauciane Garcia de; Souza, Rodrigo Wagner Alves de; Moreli, Marcos Lázaro; Figueiredo, Luíz Tadeu Moraes

doi:10.1590/s0037-86822009000300009

Cited by 29 publications

(22 citation statements)

References 20 publications

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“…Our results corroborate previous reports, from Chile, Argentina, USA and Brazil, showing that the majority of HCPS cases occur in male adults, mostly agricultural workers or people in contact with a rural environment (Campos et al 2009;Sotomayor et al 2009;Martinez et al 2010, MacNeil et al 2011, Travassos da Rosa et al 2011.…”

Section: Discussionsupporting

confidence: 92%

“…IgM antibodies to hantavirus were observed in all clinical samples independently of time of collection. As previously reported, most of our HCPS cases occurred in the dry season, April to August (Suzuki et al 2004, Campos et al 2009). Only 2 cases occurred at a different time of the year.…”

Section: Discussionsupporting

confidence: 80%

“…This fatality ratio is lower than others reported in previous studies in the region of Ribeirão Preto, which was approximately 50% (Campos et al 2009, Figueiredo et al 2009bFigueiredo et al 2010. ARAV, the causative of HCPS in the region of Ribeirão Preto is, probably, the most virulent among all Brazilian hantaviruses (Figueiredo et al 2009b).…”

Section: Discussioncontrasting

confidence: 58%

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Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Figueiredo¹,

Pádua²,

Júnior³

et al. 2011

VR&R

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Cardiopulmonary Syndrome (HCPS) is a severe disease caused by Hantaviruses. In the present study, we have analyzed sera of 62 HCPS suspected cases from the region of Ribeirão Preto, São Paulo, in the period of 2010-2011. Clinical samples of twelve patients were positive, based on both RT-PCR and IgM-ELISA. Hantavirus-infected patients included 8 males and 4 females, 16-57 years old, 3 of whom were rural workers (25%) and one of them related direct contact with wild rodents. The majority of the other patients (75%) lived in the periphery of cities and reported the presence of rodents in their homes. The case fatality ratio of these 12 HCPS cases was 41.6%. Our results confirm that hantaviruses are endemic, with occurrence of HCPS and fatalities, every year, in the region of Ribeirão Preto. More educational and preventive measures are necessary in order to prevent human infections by hantavirus in the region, and other parts of Brazil.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 58%

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Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Figueiredo¹,

Pádua²,

Júnior³

et al. 2011

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“…Tourism to rural areas has also been implicated in disease transmission [9,19]. In all these settings, environmental alterations caused by human action constitute the most common predisposing factor described in epidemiological investigations regarding these cases [13,14,18].…”

Section: Types Of Hantavirus In Brazil and Their Epidemiological Detementioning

confidence: 99%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

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“…In the sample of individuals with HCPS caused by the Araraquara virus, the mortality rate was 54.3%. (22) Adenoviruses, DNA viruses that belong to the Adenoviridae family, occur worldwide.…”

mentioning

confidence: 99%

Pneumonias virais: aspectos epidemiológicos, clínicos, fisiopatológicos e tratamento

Figueiredo

2009

J. bras. pneumol.

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In humans, the most common types of infection are respiratory tract infections, among which viral infections predominate. Viruses can also infect the low respiratory tract, causing bronchiolitis, bronchitis and pneumonia. The objective of this review article was to show epidemiological, pathophysiological, clinical and therapeutic aspects of viral community-acquired pneumonia. These types of pneumonia are commonly caused by influenza A and B; parainfluenza 1, 2 and 3; respiratory syncytial virus; or adenovirus. We also address the types of pneumonia caused by hantaviruses, metapneumoviruses and rhinoviruses.Keywords: Pneumonia, viral; Influenza, human; Respiratory syncytial virus infections; Hantavirus. ResumoAs infecções do trato respiratório são as formas de infecção mais comuns que afetam o homem e, dentre essas, predominam as de causa viral. Os vírus também podem acometer o trato respiratório baixo, causando bronquiolite, bronquite e pneumonia. Neste artigo de revisão, objetivamos mostrar aspectos epidemiológicos, fisiopatológicos, clínicos e do tratamento das pneumonias comunitárias por vírus. Essas pneumonias costumam ser causadas por vírus influenza A e B; parainfluenza 1, 2 e 3; vírus respiratório sincicial; e adenovírus. Também são apresentados aqui os hantavírus, metapneumovírus e rinovírus causando pneumonia. can actively inhibit or delay such responses. In addition, hantaviruses have an inhibiting effect on the cell receptors responsible for the maintenance of vascular integrity. More severe clinical profiles have also been associated with high viral loads. Inversely, neutralizing antibodies seem to have a protective effect against the severe forms. Descritores(6) Furthermore, in severe RSV pneumonia, high local viral replication, an exacerbated proinflammatory response and a high level of T cell activation have been observed. (7) In patients with pneumonia, there are no clinical criteria that suggest, with proven safety, the viral etiology. In addition, there are difficulties in establishing the general etiologic diagnosis of pneumonia, especially of viral pneumonia, which limits the knowledge about this disease and its causative agents. The classical description of severe viral pneumonia is based on that of the influenza A virus. Patients present with cough that is initially dry but can evolve to the production of pinkish mucous sputum, and respiratory failure, characterized by cyanosis and hypoxia. At examination, patients are found to be acutely ill, showing increased respiratory rate and crackles disseminated through the lung parenchyma projection area, as well as eventually presenting rhinitis and conjunctivitis. In RSV pneumonia, bronchitis and bronchiolitis associated with necrotic mucosal lesion and mucus plugging take on added importance.(3) In adults, high fever, leukocytosis with neutrophilia and radiological findings of lobar pneumonia do not predict the viral etiology. Similarly, in children, clinical alterations, such as an axillary temperature > 39°C, and altered complementary...

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Síndrome pulmonar e cardiovascular por hantavírus: aspectos clínicos de uma doença emergente no sudeste brasileiro

Cited by 29 publications

References 20 publications

Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pneumonias virais: aspectos epidemiológicos, clínicos, fisiopatológicos e tratamento

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