Diagnóstico molecular da malária em uma unidade de atenção terciária na Amazônia Brasileira

Costa, Mônica Regina Farias; Vieira, Pedro Paulo; Ferreira, Cynthia de Oliveira; Lacerda, Marcus Vinícius Guimarães; Alecrim, Wilson Duarte; Alecrim, Maria das Graças Costa

doi:10.1590/s0037-86822008000400011

Cited by 16 publications

(17 citation statements)

References 31 publications

(16 reference statements)

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“…Acute renal failure was mostly related to acute hemolysis in patients with G6PD deficiency. The possibility of concomitant P. malariae infection, a species known to cause acute or delayed renal complications seems highly improbable, as this species is not detected in Manaus [33]. G6PD deficiency seems to be frequent in Brazilian malaria-endemic areas, where it is not routinely screened before the prescription of antimalarials.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Characterization of Plasmodium Vivax-Associated Admissions to Pediatric Intensive Care Units in the Brazilian Amazon

et al. 2012

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Background Plasmodium vivax is responsible for a significant proportion of malaria cases worldwide and is increasingly reported as a cause of severe disease. The objective of this study was to characterize severe vivax disease among children hospitalized in intensive care units (ICUs) in the Western Brazilian Amazon, and to identify risk factors associated with disease severity.Methods and FindingsIn this retrospective study, clinical records of 34 children, 0–14 years of age hospitalized in the 11 public pediatric and neonatal ICUs of the Manaus area, were reviewed. P. falciparum monoinfection or P. falciparum/P. vivax mixed infection was diagnosed by microscopy in 10 cases, while P. vivax monoinfection was confirmed in the remaining 24 cases. Two of the 24 patients with P. vivax monoinfection died. Respiratory distress, shock and severe anemia were the most frequent complications associated with P. vivax infection. Ninety-one children hospitalized with P. vivax monoinfections but not requiring ICU were consecutively recruited in a tertiary care hospital for infectious diseases to serve as a reference population (comparators). Male sex (p = 0.039), age less than five years (p = 0.028), parasitemia greater than 500/mm3 (p = 0.018), and the presence of any acute (p = 0.023) or chronic (p = 0.017) co-morbidity were independently associated with ICU admission. At least one of the WHO severity criteria for malaria (formerly validated for P. falciparum) was present in 23/24 (95.8%) of the patients admitted to the ICU and in 17/91 (18.7%) of controls, making these criteria a good predictor of ICU admission (p = 0.001). The only investigated criterion not associated with ICU admission was hyperbilirubinemia (p = 0.513)].ConclusionsOur study points to the importance of P. vivax-associated severe disease in children, causing 72.5% of the malaria admissions to pediatric ICUs. WHO severity criteria demonstrated good sensitivity in predicting severe P. vivax infection in this small case series.

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Section: Discussionmentioning

confidence: 99%

Risk Factors and Characterization of Plasmodium Vivax-Associated Admissions to Pediatric Intensive Care Units in the Brazilian Amazon

et al. 2012

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“…(19) Despite several experiments showing that PCR is more sensitive than microscopy and its use by some authors as the gold standard in diagnosis, the employment of this technique under current conditions requires more evidence, especially due to its high cost and the sophisticated infrastructure needed for implementation. (20) …”

Section: Malariamentioning

confidence: 99%

Duffy blood group system and the malaria adaptation process in humans

Carvalho

2011

Rev. Bras. Hematol. Hemoter.

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Malaria is an acute infectious disease caused by the protozoa of the genus Plasmodium. The antigens of the Duffy Blood Group System, in addition to incompatibilities in transfusions and hemolytic disease of the newborn, are of great interest in medicine due to their association with the invasion of red blood cells by the parasite Plasmodium vivax. For invasions to occur an interaction between the parasites and antigens of the Duffy Blood Group System is necessary. In Caucasians six antigens are produced by the Duffy locus (Fya, Fyb, F3, F4, F5 and F6). It has been observed that Fy(a-b-) individuals are resistant to Plasmodium knowlesi and P. vivax infection, because the invasion requires at least one of these antigens. The P. vivax Duffy Binding Protein (PvDBP) is functionally important in the invasion process of these parasites in Duffy / DARC positive humans. The proteins or fractions may be considered, therefore, an important and potential inoculum to be used in immunization against malaria.

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“…A significativa diferença de prevalência da malária entre o exame de gota espessa (2,8%) e PCR (23,8%) já foi demonstrada em outros trabalhos 24 , mas mostra a existência de muitos indiví-duos que não apresentavam sintomas da doença no momento da coleta, sugerindo que estavam no estágio inicial da doença ou eram assintomá-ticos. A presença de indivíduos assintomáticos já foi constatada em estudos anteriores realizados na região 25,26 .…”

Section: Discussão E Consideraçõesunclassified

Malária e aspectos hematológicos em moradores da área de influência dos futuros reservatórios das hidrelétricas de Santo Antônio e Jirau, Rondônia, Brasil

Katsuragawa¹,

Cunha²,

Souza³

et al. 2009

Cad. Saúde Pública

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In Rondônia State, Brazil, two IntroduçãoAs transformações ambientais realizadas pelo homem visando o desenvolvimento e o crescimento da economia são necessárias dentro do contexto social e devem ser realizadas seguindo-se padrões legais, visando causar os menores impactos possíveis. Ambientes aquáticos são amplamente utilizados pelo homem com as mais diferentes finalidades, entre elas o abastecimento de água, geração de energia, irrigação, navegação, piscicultura ou mesmo paisagismo 1 .A construção de barragens para implantação de Usinas Hidrelétricas (UHE) é uma necessidade para o desenvolvimento de uma micro e/ou macro região, pois a oferta de energia elétrica atrai novos investimentos e, com isso, haverá o crescimento da economia local. A Região Norte do Brasil é rica em recursos hídricos. Segundo a Agência Nacional de Energia Elétrica (ANEEL; http://www.aneel.gov.br, acessado em 07/Set/2005), o potencial hidráulico, ou hidroenergético, do país é de 260GW, dos quais apenas 25% estão sendo utilizados para a produção de energia pelas UHE de médio e grande porte e pelas Pequenas Centrais Hidrelétricas (PCH). A Região Norte tem o maior potencial para geração hidráulica com 114GW, ou 44%.Para o Estado de Rondônia, estão planejadas a construção de seis UHE (Jirau, Santo Antônio, Madeira Binacional, Monte Cristo, Ávila e Ji-Paraná) e duas PCH (Cachimbo e Alta Floresta), que

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Diagnóstico molecular da malária em uma unidade de atenção terciária na Amazônia Brasileira

Cited by 16 publications

References 31 publications

Risk Factors and Characterization of Plasmodium Vivax-Associated Admissions to Pediatric Intensive Care Units in the Brazilian Amazon

Risk Factors and Characterization of Plasmodium Vivax-Associated Admissions to Pediatric Intensive Care Units in the Brazilian Amazon

Duffy blood group system and the malaria adaptation process in humans

Malária e aspectos hematológicos em moradores da área de influência dos futuros reservatórios das hidrelétricas de Santo Antônio e Jirau, Rondônia, Brasil

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