Gamna-Gandy bodies in hepatosplenic schistosomiasis mansoni

Gamna-Gandy bodies of the spleen in sickle cell disease

“…Portal hypertension is one of the pathophysiological mechanisms that explains the formation of these nodules. Patients with increased blood pressure in the splenic circulatory system are likely to have episodes of minimal bleeding in the splenic parenchyma, which is organized as hemosiderin (iron), calcium salts and fibrotic tissue 1 , 2 , 6 , 7. GGBs in the spleen can occur with three main patterns: i) fine granular deposits in the red pulp; ii) iron deposits associated with subcapsular infarcts; and iii) periarterial deposits associated with fibrosis 2.…”