Oral cavity lymphoma as secondary AIDS-defining neoplasm in a patient on HAART with immune reconstitution

Corti, Marcelo; Solari, Hernán G.; Cangelosi, Diana; Carolis, Luis De; Schtirbu, Ricardo; Lewi, Daniel

doi:10.1590/s0037-86822007000500017

Cited by 10 publications

(10 citation statements)

References 9 publications

(8 reference statements)

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“…Theoretically, any pathogen that can cause an opportunistic infection could appear in immune‐reconstituted patients, so it would be expected that oral diseases in HIV‐infected patients could be associated with IRIS (Tsang and Samaranayake, ). As shown in Table , regrettably, there are scarce studies on the oral manifestations of IRIS, mainly case reports and retrospective studies (Jevtović et al , ; Leidner and Aboulafia, ; Corti et al , ; Feller et al , ; Gaitán‐Cepeda et al , ; Ortega et al , ; Papagatsia et al , ; Briggs and Kinghorn, ). A weakness of the three aforementioned retrospective studies is that none include a strict IRIS definition, nor do they state a precise time of the onset of the lesions in relation to the initiation of HAART (Jevtović et al , ; Gaitán‐Cepeda et al , ; Ortega et al , ).…”

Section: Are Oral Manifestations Of Hiv Still Relevant After the Intrmentioning

confidence: 99%

“…The most frequent oral manifestation reported as part of IRIS has been oral Kaposi's sarcoma (KS) (Leidner and Aboulafia, ; Feller et al , ; Papagatsia et al , ; Ramírez‐Amador et al , ; Ablanedo‐Terrazas et al , ), followed by OC (Jevtović et al , ; Gaitán‐Cepeda et al , ; Ramírez‐Amador et al , ), oral hairy leukoplakia (OHL) (Gaitán‐Cepeda et al , ; Ramírez‐Amador et al , ), herpes simplex infection (HS) (Briggs and Kinghorn, ), oral ulcers (Ramírez‐Amador et al , ), non‐Hodgkin's lymphoma (NHL) (Corti et al , ), and parotid gland enlargement (Ortega et al , ) (Table ). It has been suggested that HPV‐OL could be a form of IRIS (Patton et al , ; Greenspan et al , ; King et al , ; Flint et al , ).…”

Section: Are Oral Manifestations Of Hiv Still Relevant After the Intrmentioning

confidence: 99%

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Urban legends series: oral manifestations of HIV infection

et al. 2013

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Human immunodeficiency virus-related oral lesions (HIV-OLs), such as oral candidiasis (OC) and oral hairy leukoplakia (OHL), have been recognized as indicators of immune suppression since the beginning of the global HIV epidemic. The diagnosis and management of HIV disease and spectrum of opportunistic infection has changed over the past 30 years as our understanding of the infection has evolved. We investigated the following controversial topics: (i) Are oral manifestations of HIV still relevant after the introduction of highly active antiretroviral therapy (HAART)? (ii) Can we nowadays still diagnose HIV infection through oral lesions? (iii) Is the actual classification of oral manifestations of HIV adequate or does it need to be reviewed and updated? (iv) Is there any novelty in the treatment of oral manifestations of HIV infection? Results from extensive literature review suggested the following: (i) While HAART has resulted in significant reductions in HIV-OLs, many are still seen in patients with HIV infection, with OC remaining the most common lesion. While the relationship between oral warts and the immune reconstitution inflammatory syndrome is less clear, the malignant potential of oral human papillomavirus infection is gaining increasing attention. (ii) Effective antiretroviral therapy has transformed HIV from a fatal illness to a chronic manageable condition and as a result expanded screening policies for HIV are being advocated both in developed and in developing countries. Affordable, reliable, and easy-to-use diagnostic techniques have been recently introduced likely restricting the importance of HIV-OLs in diagnosis. (iii) The 1993 EC-Clearinghouse classification of HIV-OLs is still globally used despite controversy on the relevance of periodontal diseases today. HIV-OL case definitions were updated in 2009 to facilitate the accuracy of HIV-OL diagnoses by non-dental healthcare workers in large-scale epidemiologic studies and clinical trials. (iv) Research over the last 6 years on novel modalities for the treatment of HIV-OLs has been reported for OC and OHL.

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Section: Are Oral Manifestations Of Hiv Still Relevant After the Intrmentioning

confidence: 99%

Section: Are Oral Manifestations Of Hiv Still Relevant After the Intrmentioning

confidence: 99%

Urban legends series: oral manifestations of HIV infection

et al. 2013

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“…These lymphomas are characterized by their rapid progression, frequent extranodal initial manifestations, and poor outcome [2]. Oral cavity is a rare site of presentation for NHL in AIDS patients and only 3% of them involve primarily the oral cavity [3,4].…”

Section: Introductionmentioning

confidence: 99%

Non-Hodgkin Lymphomas of the Oral Cavity in AIDS Patients in a Reference Hospital of Infectious Diseases in Argentina: Report of Eleven Cases and Review of the Literature

Corti

Villafañe

Solari

et al. 2010

J Gastrointest Canc

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“…The estimated related risk of NHL associated with HIV infection is 100 times greater than in general population, and the risk increases with the progressive immunosuppression related with retrovirus. [1][2][3][4] More than 90% of HIV-associated NHL is derived from B cells and the majority is high grade. Extranodal presentation is most frequent in HIV-seropositive patients than in general population and occurs in 70% to 80% of the cases.…”

Section: Introductionmentioning

confidence: 99%

Non Hodgkin's lymphoma with cutaneous involvement in AIDS patients: report of five cases and review of the literature

Corti¹,

Carolis²,

Solari³

et al. 2010

Braz J Infect Dis

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Cutaneous B cell lymphoma (CBCL) is a lymphoproliferative disorder of neoplastic B cell of the skin with a wide range of clinical manifestations. Commonly, the clinical features of CBCL are plaques, nodules, or ulcerative lesions. Skin is one of the common sites for extra-nodal lymphomas in patients with AIDS and B cell type is less common than T cell type. Only recently, the existence of B cell lymphomas presenting clinically in the skin without evidence of extra-cutaneous involvement has been accepted as primary CBCL. Here, we are presenting 5 patients with cutaneous involvement in the setting of HIV/AIDS disease. Two of them were primary cutaneous nonHodgkin lymphomas. All were CBCL; 3 were immunoblastic, 1 was plasmablastic, and the other was a Burkitt lymphoma. We analyzed the epidemiological, clinical, virological, and immunological characteristics of this group of patients.

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Oral cavity lymphoma as secondary AIDS-defining neoplasm in a patient on HAART with immune reconstitution

Cited by 10 publications

References 9 publications

Urban legends series: oral manifestations of HIV infection

Urban legends series: oral manifestations of HIV infection

Non-Hodgkin Lymphomas of the Oral Cavity in AIDS Patients in a Reference Hospital of Infectious Diseases in Argentina: Report of Eleven Cases and Review of the Literature

Non Hodgkin's lymphoma with cutaneous involvement in AIDS patients: report of five cases and review of the literature

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