Clinical and ultrasound findings before and after praziquantel treatment among Venezuelan schistosomiasis patients

Ruiz-Guevara, Raiza; Noya, Belkisyolé Alarcón de; Valero, Sharon Kay; Lecuna, Pablo; Garassini, M; Noya, Óscar

doi:10.1590/s0037-86822007000500003

Cited by 33 publications

(24 citation statements)

References 29 publications

(14 reference statements)

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“…Qiu et al (2000) also supported the evidence that liver fibrosis due to S. japonicum could recover to a certain extent after praziquantel treatment. Ruiz-Guevara et al (2007) indicated that 3-5 years after praziquantel treatment among Venezuelan patients with S. mansoni infection, complete reversal of periportal lesions was observed in 28.2% of the cases and progression of the disease in 5.1%. Another research in Ethiopia also revealed the reversibility of schistosomal periportal fibrosis after praziquantel therapy (Berhe et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice

Huang

et al. 2011

Parasitol Res

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Schistosomiasis remains a major public health problem and it is an immune disease. The schistosome egg is the primary parasite factor responsible for the overt disease. The eggs release the soluble antigen, which induces intensive tissue reaction, a granulomatous reaction to the eggs. If granuloma formation could be suppressed, overt disease might not develop. Praziquantel is an effective antischistosomal drug especially for adult worms. However, whether praziquantel has a suppressing effect on granuloma formation around schistosome eggs directly remains unclear. The purpose of the present study was to investigate the effect of praziquantel, especially administered persistently, on granuloma formation around Schistosoma japonicum eggs in the lung of sensitized mice. Thirty-six mice were divided into three groups averagely. Group A was a control group. First, the mice were injected with schistosomal eggs hypodermically in abdomen, and 10 days later injected with schistosomal eggs intravenously via a tail vein. Group B was a praziquantel short administration group. In addition to the injections of schistosomal eggs as the same of Group A, the mice were administered with praziquantel in a daily dose of 300 mg/kg for 3 days, from 1 day before the intravenous injection of the eggs. Group C was a praziquantel prolonged administration group. In addition to the injections of schistosomal eggs as the same of Group A, the mice were administered with praziquantel in a daily dose of 150 mg/kg for 5 days weekly until the mice were sacrificed. Three mice of each group were sacrificed on days 7, 14, 28, and 56, respectively after the intravenous injection of the eggs, and the lung tissues were fixed with formalin and the slices were HE stained. The granulomas containing eggs in their centers were selected, and 25-30 granulomas from the animals of each group were measured at each time period. The mean areas of egg granulomas of each group were calculated, and the neutrophilic granulocytes, eosinocytes, lymphocytes, fibroblasts, and macrophages within the egg granulomas were counted. The mean numbers of them of each group were calculated. All the data of each group were analyzed and compared statistically. On day 56 after the intravenous injection of the eggs, the mean area of schistosomal egg granulomas in group B was (227.4 ± 728.0) × 10(3) μm(2), less than that of [(297.9 ± 153.3) × 10(3) μm(2)] in group A, and the suppression rate was 23.7% (P < 0.05). On days 7, 14, 28, and 56, the mean areas of schistosomal egg granulomas in group C were (575.8 ± 155.6) × 10(3) μm(2), (310.5 ± 854.0) × 10(3) μm(2), (267.7 ± 513.3) × 10(3) μm(2), and (214.9 ± 446.4) × 10(3) μm(2), respectively, significantly less than those of [(692.7 ± 232.6) × 10(3) μm(2), (439.4 ± 165.0) × 10(3) μm(2), (385.7 ± 129.3) × 10(3) μm(2), and (297.9 ± 153.3) × 10(3) μm(2)] in group A. The suppression rates were 16.9%, 29.3%, 30.6%, and 27.9%, respectively (P values <0.05). On day 56, the mean numbers of neutrophilic granulocytes were 11.4 ± 5.0 in group A and 5...

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Section: Discussionmentioning

confidence: 99%

Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice

Huang

et al. 2011

Parasitol Res

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“…Considered a simple, safe and low-cost method, after the advent of portable equipment, it has been of invaluable help in the screening of populations living in endemic areas and in field-based studies of the disease. Taken as a nearly ideal tool in the diagnosis and classification of schistosomiasis, it is now used as a surrogate for the gold-standard in the diagnosis of schistosomiasis-related liver fibrosis (Doehring-Schwerdtfeger et al 1989, Abdel-Wahab et al 1992, Richter et al 1992, Abdel-Wahab & Strickland 1993, pinto-Silva et al 1994, Richter 2000, Kariuki et al 2001, Cota et al 2006, Marinho et al 2006, Ruiz-Guevara et al 2007.…”

mentioning

confidence: 99%

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Marinho¹,

Bretas

Voieta³

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…WHO patterns B-D, representing patients with mild liver fibrosis, are not pathognomonic and can be difficult to differentiate from normal liver or other disease etiologies. 65 The interobserver agreement has been found to be low, especially for mild cases. 66 Without the US imaging experience needed to subcategorize these patients accurately, misdiagnosis of milder cases of intestinal schistosomiasis can easily occur.…”

Section: Other Infectious Diseases With Potential For Pocus Applicationmentioning

confidence: 97%

Point-of-Care Ultrasound Assessment of Tropical Infectious Diseases—A Review of Applications and Perspectives

Bélard¹,

Tamarozzi²,

Bustinduy³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. The development of good quality and affordable ultrasound machines has led to the establishment and implementation of numerous point-of-care ultrasound (POCUS) protocols in various medical disciplines. POCUS for major infectious diseases endemic in tropical regions has received less attention, despite its likely even more pronounced benefit for populations with limited access to imaging infrastructure. Focused assessment with sonography for HIV-associated TB (FASH) and echinococcosis (FASE) are the only two POCUS protocols for tropical infectious diseases, which have been formally investigated and which have been implemented in routine patient care today. This review collates the available evidence for FASH and FASE, and discusses sonographic experiences reported for urinary and intestinal schistosomiasis, lymphatic filariasis, viral hemorrhagic fevers, amebic liver abscess, and visceral leishmaniasis. Potential POCUS protocols are suggested and technical as well as training aspects in the context of resourcelimited settings are reviewed. Using the focused approach for tropical infectious diseases will make ultrasound diagnosis available to patients who would otherwise have very limited or no access to medical imaging.

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Clinical and ultrasound findings before and after praziquantel treatment among Venezuelan schistosomiasis patients

Abstract: Abdominal ultrasound can be a useful tool for diagnosing periportal fibrosis related to

Cited by 33 publications

References 29 publications

Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice

Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Point-of-Care Ultrasound Assessment of Tropical Infectious Diseases—A Review of Applications and Perspectives

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