Acute disseminated encephalomyelitis in classic dengue

Brito, Carlos; Sobreira, Silvana; Cordeiro, Marli Tenório; Lucena‐Silva, Norma

doi:10.1590/s0037-86822007000200019

Cited by 25 publications

(18 citation statements)

References 8 publications

(2 reference statements)

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“…Similar observations were made in dengue fever patients in Brazil (84) (85) (86) . High copy number of Zika virus RNA was detected in the urine, serum, and cerebrospinal fluid of the Mexican subject.…”

Section: Zika Virus Gbs and Other Neurological Disorders In Adultssupporting

confidence: 84%

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Silva

Souza

2016

Rev. Soc. Bras. Med. Trop.

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The Zika virus epidemic that started in Brazil in 2014 has spread to >30 countries and territories in Latin America, leading to a rapid rise in the incidence of microcephalic newborns and adults with neurological complications. At the beginning of the outbreak, little was known about Zika virus morphology, genome structure, modes of transmission, and its potential to cause neurological malformations and disorders. With the advancement of basic science, discoveries of the mechanisms of strain variability, viral transfer to the fetus, and neurovirulence were published. These will certainly lead to the development of strategies to block vertical viral transmission, neuronal invasion, and pathogenesis in the near future. This paper reviews the current literature on Zika virus infections, with the aim of gaining a holistic insight into their etiology and pathogenesis. We discuss Zika virus history and epidemiology in Brazil, viral structure and taxonomy, old and newly identified transmission modes, and neurological consequences of infection.

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Section: Zika Virus Gbs and Other Neurological Disorders In Adultssupporting

confidence: 84%

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Silva

Souza

2016

Rev. Soc. Bras. Med. Trop.

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“…[1][2][3] Isolated phrenic neuropathy and diaphragmatic paralysis following dengue is extremely rare and only a single such association has been described. [4] We report the second such patient.…”

Section: Unilateral Diaphragmatic Paralysis Following Dengue Infectionmentioning

confidence: 84%

“…[1][2][3] Imaging studies in ADEM following dengue are few. In the patient described by Brito et al, [4] the MRI showed white matter lesions in the centrum semiovale, corona radiata, callosal-septal interface and thalamus and in the patient examined by Yamamoto et al, [5] thoracic spinal cord showing demyelinating lesion was described. [5] Our patient had extensive involvement of the frontal, parietal and temporal white matter as well as the corpus callosum.…”

Section: Acute Disseminating Encephalomyelitis With Hemorrhage Followmentioning

confidence: 91%

Acute disseminating encephalomyelitis with hemorrhage following dengue

Gera

George

2010

Neurol India

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“…37,[55][56][57][58][59][60][61] Neurological symptoms include seizures, altered sensorium, and focal neurological deficits; they may occur following the hyperpyrexic phase of dengue. 57,58 Mild pleocytosis and moderate rise in protein concentration can be detected in the CSF.…”

Section: Acute Disseminated Encephalomyelitismentioning

confidence: 99%

Neurological manifestations of dengue viral infection

Carod-Artal

2014

RRTM

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Dengue is the most common mosquito-borne viral infection worldwide. There is increased evidence for dengue virus neurotropism, and neurological manifestations could make part of the clinical picture of dengue virus infection in at least 0.5%-7.4% of symptomatic cases. Neurological complications have been classified into dengue virus encephalopathy, dengue virus encephalitis, immune-mediated syndromes (acute disseminated encephalomyelitis, myelitis, Guillain-Barré syndrome, neuritis brachialis, acute cerebellitis, and others), neuromuscular complications (hypokalemic paralysis, transient benign muscle dysfunction and myositis), and dengue-associated stroke. Common neuro-ophthalmic complications are maculopathy and retinal vasculopathy. Pathogenic mechanisms include systemic complications and metabolic disturbances resulting in encephalopathy, direct effect of the virus provoking encephalitis, and postinfectious immune mechanisms causing immune-mediated syndromes. Dengue viruses should be considered as a cause of neurological disorders in endemic regions. Standardized case definitions for specific neurological complications are still needed.

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Acute disseminated encephalomyelitis in classic dengue

Abstract: Neurological manifestation is uncommon in dengue infection

Cited by 25 publications

References 8 publications

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Acute disseminating encephalomyelitis with hemorrhage following dengue

Neurological manifestations of dengue viral infection

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