Criptococose associada à Aids: a importância do cultivo da urina no seu diagnóstico

Pinto, Vítor Laerte; Galhardo, Maria Clara Gutierrez; Lazéra, Márcia dos Santos; Wanke, Bodo; Reis, Rodrigo S.; Perez, M. L. Soriano

doi:10.1590/s0037-86822006000200020

Cited by 7 publications

(3 citation statements)

References 9 publications

(7 reference statements)

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“…8 Thus, we suggest the routine examination of urinary sediment for immunosuppressed patients with fever, especially transplant and with AIDS. [19][20][21] Our study showed that cryptococcuria could occur not only in HIV-infected patients but also in patients with other immunocompromised conditions, such as transplant, and even in immunocompetent patients, as already reported in literature. 5 Cryptococcus identified in urine is suggested as a potential early indicator of disseminated disease.…”

Section: Discussionsupporting

confidence: 64%

“…However, the urine has been a very useful diagnostic, especially if processed with nigrosine dye for microscopy of urinary sediment (demonstration of the capsule) and grown in medium with niger seed (Staib agar – reveal the melanin) 8 . Thus, we suggest the routine examination of urinary sediment for immunosuppressed patients with fever, especially transplant and with AIDS 19–21 …”

Section: Discussionmentioning

confidence: 99%

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Cryptococcuria as manifestation of disseminated cryptococcosis: Staib agar as a selective identification medium

Severo¹,

Pinto²,

Sotilli³

et al. 2011

Mycoses

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We conducted a retrospective study of 58 cases of cryptococcosis (1986-2008) with urine test positive for Cryptococcus sp, in Mycology Laboratory, Santa Casa-Hospital Complex, Porto Alegre, RS, Brazil. The diagnosis of cryptococcuria was based on microscopic examination and culture of urinary sediment. Cryptococcus was isolated from other clinical specimens such as blood, cerebrospinal fluid, ascitic and pleural fluids, respiratory secretions, biopsies of skin, nasal and bone marrow. Cryptocccus neoformans was present in 55 cases and Cryptocccus gattii in three cases. Males predominated (79.3%); age ranged from 12 to 86 years. Acquired Immune Deficiency Syndrome (AIDS) were present in 60.3%, 31.1% did not have AIDS and 5.2% were apparently immunocompetent patients. The most frequent signs and symptoms were headache (53.4%) and fever (51.7%). The most widely used medication was the amphotericin B (43 patients). The mortality rate was 45%. We conclude that the mycological examination of the urine can be an alternative simple, non-invasive and useful in diagnosis of disseminated cryptococcosis, especially when used in conjunction with techniques for demonstration of the capsule (nigrosine) and/or production of melanin in special culture media (Staib agar).

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Cryptococcuria as manifestation of disseminated cryptococcosis: Staib agar as a selective identification medium

Severo¹,

Pinto²,

Sotilli³

et al. 2011

Mycoses

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“…Of the HIV-infected patients, 45.6% had 5 leukocytes/mm 3 or less, a finding that stresses the importance of surveying fungi even when cytological parameters are normal. Other investigators also report decreased inflammatory response in CSF in patients with AIDS 17 .…”

Section: Discussionmentioning

confidence: 87%

Clinical and epidemiological features of 123 cases of cryptococcosis in Mato Grosso do Sul, Brazil

Lindenberg¹,

Chang

Paniago

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYTo identify the clinical and epidemiological profile of cryptococcosis diagnosed at the University Hospital of the Federal University of Mato Grosso do Sul, Brazil, medical records of 123 patients admitted from January 1995 to December 2005 were analyzed. One hundred and four cases (84.5%) had HIV infection, six (4.9%) had other predisposing conditions and 13 (10.6%) were immunocompetent. Male patients predominated (68.3%) and their age ranged from 19 to 69 years (mean: 35.9). Most patients (73.2%) were born and lived lifelong in the state of Mato Grosso do Sul. Involvement of the central nervous system occurred in 103 patients (83.7%) and headache and vomiting were the most frequent symptoms. In 77 cases it was possible to identify the Cryptococcus species: 69 (89.6%) C. neoformans and eight (10.4%) C. gattii. Amphotericin B was the drug of choice for treatment (106/123), followed by fluconazole in 60% of cases. The overall lethality rate was 49.6%, being 51% among the HIV infected patients and 41.2% among the non-HIV infected (p > 0.05). Although cryptococcosis exhibited in our region a similar behavior to that described in the literature, the detection of an important rate of immunocompetent individuals and five C. gattii cryptococcosis in HIV-infected patients is noteworthy.

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Cutaneous and pulmonary cryptococcosis

Markman

Oliveira

Takano

et al. 2020

Anais Brasileiros de Dermatologia

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Criptococose associada à Aids: a importância do cultivo da urina no seu diagnóstico

Cited by 7 publications

References 9 publications

Cryptococcuria as manifestation of disseminated cryptococcosis: Staib agar as a selective identification medium

Cryptococcuria as manifestation of disseminated cryptococcosis: Staib agar as a selective identification medium

Clinical and epidemiological features of 123 cases of cryptococcosis in Mato Grosso do Sul, Brazil

Cutaneous and pulmonary cryptococcosis

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