Fasciolíase: relato de dois casos em área rural do Rio de Janeiro

Igreja, Ricardo Pereira; Barreto, Magali Gonçalves Muniz; Soares, Marisa da Silveira

doi:10.1590/s0037-86822004000500010

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…Although it stills a little-known disease, it is estimated that about 750 million people worldwide are at risk of infection (Elelu & Eisler, 2017). An estimative of the cases in Brazil would be imprecise, since the number of cases has an unofficial picture (Igreja et al, 2004;Mezzari et al, 2000;Oliveira et al, 2007;Pile et al, 2000). More recently, however, a systematic review of literature from 1950 to 2016 by Pritsch and Molento (2018) affirmed the prevalence of 48 cases in Brazil, two of them in the South of Bahia.…”

Section: Introductionmentioning

confidence: 99%

Geospatial and Transmission Evidences of the Human Fascioliasis Cases (2012-2017) in South Bahia, Brazil

Oliveira

Silva

et al. 2020

BJD

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Section: Introductionmentioning

confidence: 99%

Geospatial and Transmission Evidences of the Human Fascioliasis Cases (2012-2017) in South Bahia, Brazil

Oliveira

Silva

et al. 2020

BJD

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Neurological and Ocular Fascioliasis in Humans

Mas‐Coma

Agramunt

Valero

2014

Advances in Parasitology

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Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens

Drescher,

dos Santos,

Pinto

et al. 2024

Microbiol Spectr

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Bovine fasciolosis is a parasitic disease with a global reach. Coprological based on egg detection in fecal samples and liver inspection to evaluate the presence of the parasite is currently the gold standard for diagnosing chronic fasciolosis in cattle. However, these techniques are labor-intensive and ineffective during the acute phase of the disease. Serodiagnosis using native and recombinant antigens has become an interesting alternative in efforts to identify cattle fasciolosis. We evaluated cattle from abattoir ( n = 139) and farms ( n = 500) through liver inspection and coprological examination, respectively. Our laboratory team optimized and validated enzyme-linked immunosorbent assay tests based on somatic antigen, excretory/secretory proteins, and the recombinant antigen cathepsin L-1 to detect serum antibodies against fasciolosis in cattle. For animals from abattoir, 10 were positive for fasciolosis according to liver inspection. Both Fh ES and Fh rCL-1 presented an area under the receiver operating characteristic (AUROC) curve of 0.80, with a sensitivity of 0.80 (95% CI: 0.46–0.95) and 0.70 (95% CI: 0.38–0.90) and specificity of 0.81 (95% CI: 0.73–0.87) and 0.87 (95% CI: 0.80–0.92), respectively. For those cattle from farms, 28 were positive only for fasciolosis according to coprological examination. In this scenario, Fh ES gave the best performance, with an AUROC of 0.84, sensitivity of 0.79 (95% CI: 0.60–0.90), and specificity of 0.86 (95% CI: 0.82–0.89). In conclusion, our study highlights the potential of serodiagnosis for accurately screening cattle fasciolosis. The promising sensitivity and specificity values of Fh ES when compared to liver inspection or coprological examination enhance its importance for cattle fasciolosis diagnosis. IMPORTANCE The aim of this article was to identify antibodies against fasciolosis in cattle in Brazil. The methodology was reproduced in our laboratory and applied for the first time to the Brazilian cattle herd. The antigens tested can be used as a screening test and thus speed up the diagnosis of bovine fascioliasis.

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Fasciolíase: relato de dois casos em área rural do Rio de Janeiro

Cited by 6 publications

References 2 publications

Geospatial and Transmission Evidences of the Human Fascioliasis Cases (2012-2017) in South Bahia, Brazil

Geospatial and Transmission Evidences of the Human Fascioliasis Cases (2012-2017) in South Bahia, Brazil

Neurological and Ocular Fascioliasis in Humans

Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens

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