Recurrent oedema associated with the co-formulation of lopinavir and ritonavir

Bilateral pedal edema in an HIV patient: Lopinavir/Ritonavir-containing treatment regimen as a potential cause?

“…The pedal edema subsequent to the use of Olanzepine, Lithium, and Acitretin resolved only after the offending medications were withdrawn in the patients reported. Interestingly, in our patient and for the other case reports of pedal edema subsequent to the use of Lopinavir/Ritonavir [4][5][6], the edema resolved with supportive therapy despite the maintenance of Lopinavir/Ritonavir.…”

“…Facial or pedal edema is not listed as one of the adverse effects in patient package inserts of Lopinavir/Ritonavir (Patient Package Insert of Kaletra® Abbott Laboratories, North Chicago, IL 60064. USA September 15, 2000); however, inflammatory edema of the legs in association with a Lopinavir/Ritonavir-containing Highly Active Antiretroviral Therapy (HAART) regimen has been reported in two patients in France [4] and four patients in Brazil [5,6]. A patient who developed edema during Ritonavir treatment without Lopinavir has also been reported [7].…”