2003
DOI: 10.1590/s0037-86822003000400002
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Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias

Abstract: Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting Chagas' disease reactivation, submitted to treatment with benznidazole. In the present study, we investigated whether there is a potentiation in the generation of lymphomas in chronically infected mice, treated with immunosuppressive drugs and benznidazole. For … Show more

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Cited by 12 publications
(8 citation statements)
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“…We also think that the anti-inflammatory effects of immunosuppressive drugs are controversial, since to achieve an adequate modulation of the inflammatory reaction, the dose and time span of drug application should be considered. Andrade et al [29] indirectly confirm our data, in which T. cruzi chronically infected Swiss mice treated with benznidazole and immune-suppressive drugs such as cyclosporine did not contribute to the appearance of lymphomas or other neoplasias in these animals. Among the various aspects of the pathogenesis and physiopathology of chronic Chagas' disease, megacolon is one of the clinical manifestations.…”
Section: Discussionsupporting
confidence: 90%
“…We also think that the anti-inflammatory effects of immunosuppressive drugs are controversial, since to achieve an adequate modulation of the inflammatory reaction, the dose and time span of drug application should be considered. Andrade et al [29] indirectly confirm our data, in which T. cruzi chronically infected Swiss mice treated with benznidazole and immune-suppressive drugs such as cyclosporine did not contribute to the appearance of lymphomas or other neoplasias in these animals. Among the various aspects of the pathogenesis and physiopathology of chronic Chagas' disease, megacolon is one of the clinical manifestations.…”
Section: Discussionsupporting
confidence: 90%
“…Based on clinical observations, some authors have speculated as to whether benznidazole treatment in immunosuppressed patients might actually cause neoplasms [10], [53]. However, several clinical studies with long follow-up have found no evidence of a higher incidence of histological signs of malignancy in such patients [11], [52], [54].…”
Section: Resultsmentioning
confidence: 99%
“…Other experimental studies in the literature did not corroborate this hypothesis. 25 Nevertheless, it is well established in the medical literature that high doses and prolonged use of immunosuppressive drugs may predispose one to development of neoplasms after solidorgan transplantation. 26,27 In our study, 4 of 7 patients who developed neoplasms received higher doses of cyclosporine (5 to 10 mg/kg/day) according to the immunosuppressive protocol before January 1991.…”
Section: Discussionmentioning
confidence: 99%