Soroprevalência de anticorpos contra o antígeno CagA do Helicobacter pylori em pacientes com úlcera gástrica na região Norte do Brasil

Abstract

Helicobacter pylori is a pathogenic agent with a worldwide distribution and is involved in the development of many gastrointestinal diseases. Nowadays infection with the virulent strain CagA+ of H. pylori is considered one of the main etiological factors in the development of gastric ulcer. Based on this information, we investigated the seroprevalence of virulent strains among patients with gastric ulcer from one region, using serologic tests to detect antibodies against H. pylori and CagA protein. Infection by the virulent strain was found in 82% (40/55) of the patients, and among these, 89% (40/45) presented an increased degree of inflammation in the gastric mucosa, with a dense infiltration of leukocytes in the tissue, which probably favored the formation of gastric ulcer. We concluded that the presence of the virulent strain is related to the development of an increased inflammation in the gastric mucosa.

Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region

“…However, only a few studies have investigated the occurrence of H. pylori in the State of Pará, and these studies have been restricted to the capital, Belém. In Belém, there is a high prevalence of H. pylori infection among adult patients with gastric disorders, which ranges from 64% to 74% in patients with gastritis 4,6 and is 82% in patients with gastric ulcer 7 .…”

Badthingscomeinsmallpackages”:predicting Venom-Induced Coagulopathy in Bothropsatrox Bites Using Snake Ontogenetic Parameters

“…A gastrite crônica, forma mais comum de gastrite, ocorre quando há inflamação crônica da mucosa gástrica provocada por condições ambientais ou autoimunes, o que favorece o surgimento de gastrite atrófica, metaplasia e úlcera péptica (EVERHART, JE, 2000;AVERBACH, M. et al, 2018). Nas úlceras pépticas, cuja detecção de HP é em torno de 80 %, há diminuição das defesas da mucosa gástrica (MARTINS, LC, 2001;MARTINS, LC. et al, 2006;COELHO, LGV, 1998).…”

Análise Histológica Da Mucosa Gástrica Saudável E Doente Com Gastrite Crônica Ou Doença Ulcerosa Péptica

“…A infecção pela bactéria resulta em um processo inflamatório agudo ou crônico da mucosa gástrica. 2 A úlcera duodenal ocorre mais frequentemente na primeira porção do duodeno à distância de até três centímetros do piloro. É nitidamente demarcada e profunda, podendo atingir a camada muscular própria.…”