Epidemiologia e etiologia das dermatofitoses em Goiânia, GO, Brasil

Costa, Maria Alice Nunes; Xs, Passos; Lk, Hasimoto e Souza; At, Miranda; A, Lemos Jde; Jg, Oliveira; R, Silva Mdo

doi:10.1590/s0037-86822002000100004

Cited by 41 publications

(24 citation statements)

References 5 publications

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“…No Brasil, existe uma prevalência maior, por características adaptativas, da espécie Trichophyton rubrum 7 . Concluiu-se que os resultados obtidos demonstram a grande capacidade das formigas em manter associações com bactérias: cocos Gram positivos, bacilos Gram negativos e bacilos Gram positivos, da mesma forma e mesmo tempo conseguem manter associadas a fungos leveduriformes e filamentosos.…”

Section: Resultsunclassified

Formigas como veiculadoras de microrganismos em ambiente hospitalar

Pereira

Ueno

2008

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 41(5):492-495, set-out, 2008 ARTIGO/ARTICLEFormigas são insetos sociais que adaptam-se com facilidade aos ambientes urbanos, instalando-se em residências e ambientes hospitalares, sua presença pode determinar a disseminação de microrganismos através da veiculação mecânica. Sendo assim, existe preocupação sobre as reais possibilidades de agravos à saúde pública que possam ser causados pela veiculação de agentes patogênicos através de formigas urbanas.Entre ABSTRACTConcern exists regarding the real possibility of public health threats caused by pathogenic agents that are carried by urban ants. The present study had the objective of isolating and identifying the microorganisms that are associated with ants in hospital environments. One hundred and twenty-five ants of the same species were collected from different units of a university hospital. Each ant was collected using a swab soaked with physiological solution and was transferred to a tube containing brain heart infusion broth and incubated at 35ºC for 24 hours. From each tube, with growth, inoculations were made into specific culturing media, to isolate any microorganisms. The ants presented a high capacity for carrying microorganism groups: spore-producing Gram-positive bacilli 63.5%, Gram-negative bacilli 6.3%, Gram-positive cocci 23.1%, filamentous fungi 6.7% and yeast 0.5%. Thus, it can be inferred that ants may be one of the agents responsible for disseminating microorganisms in hospital environments.

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Section: Resultsunclassified

Formigas como veiculadoras de microrganismos em ambiente hospitalar

Pereira

Ueno

2008

Rev. Soc. Bras. Med. Trop.

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“…4 It is estimated that about 10-15% of the human population might be infected by any fungi in the course of their life. 5 …”

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confidence: 99%

Identification of fungi species in the onychomycosis of institutionalized elderly

Vasconcellos

Pereira

Souza

et al. 2013

An. Bras. Dermatol.

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BACKGROUND Superficial fungal infections are caused by dermatophytes, yeasts or filamentous fungi. They are correlated to the etiologic agent, the level of integrity of the host immune response, the site of the lesion and also the injured tissue. OBJECTIVE The purpose of this study is to isolate and to identify onychomycosis agents in institutionalized elderly (60 years old +). METHODS The identification of the fungi relied upon the combined results of mycological examination, culture isolation and micro cultures observation under light microscopy from nail and interdigital scales, which were collected from 35 elderly with a clinical suspicion of onychomycosis and a control group (9 elderly with healthy interdigital space and nails). Both groups were institutionalized in two nursing homes in Sao Bernardo do Campo, SP, Brazil. RESULTS The nail scrapings showed 51.40% positivity. Of these, dermatophytes were found in 44.40% isolates, 27.78% identified as Trichophyton rubrum and 5.56% each as Trichophyton tonsurans, Trichophyton mentagrophytes and Microsporum gypseum. The second more conspicuous group showed 38.89% yeasts: 16.67% Candida guilliermondii, 11.11% Candida parapsilosis, 5.56% Candida glabrata, and 5.56% Trichosporon asahii. A third group displayed 16.70% filamentous fungi, like Fusarium sp, Aspergillus sp and Neoscytalidium sp (5.56% each). The interdigital scrapings presented a positivity rate of 14.29%. The agents were coincident with the fungi that caused the onychomycosis. In the control group, Candida guilliermondii was found at interdigital space in one person. CONCLUSION Employing a combination of those identification methods, we found no difference between the etiology of the institutionalized elderly onychomycosis from that reported in the literature for the general population.

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“…This disease mainly affects children, the elderly, and immunocompromised individuals, such as patients receiving immunosuppressive therapy or AIDS patients (14)(15)(16)(17)(18). The disorders caused by M. canis infection are not well controlled to date, and M. canis is still one of the most common dermatophytes to cause human tinea capitis in Europe (19,20) as well as in South America (21,22). Moreover, it is also the principal pathogen that causes tinea capitis in most areas of China according to recent reports (23,24).…”

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Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome

Mao

Zhang

et al. 2014

Infect Immun

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Microsporum canis is a pathogenic fungus with worldwide distribution that causes tinea capitis in animals and humans. M. canis also causes invasive infection in immunocompromised patients. To defy pathogenic fungal infection, the host innate immune system is the first line of defense. As an important arm of innate immunity, the inflammasomes are intracellular multiprotein complexes that control the activation of caspase-1, which cleaves proinflammatory cytokine pro-interleukin-1␤ (IL-1␤) into its mature form. To determine whether the inflammasome is involved in the host defense against M. canis infection, we challenged human monocytic THP-1 cells and mouse dendritic cells with a clinical strain of M. canis isolated from patients with tinea capitis. We found that M. canis infection triggered rapid secretion of IL-1␤ from both THP-1 cells and mouse dendritic cells. Moreover, by using gene-specific shRNA and competitive inhibitors, we determined that M. canis-induced IL-1␤ secretion was dependent on NLRP3. The pathways proposed for NLRP3 inflammasome activation, namely, cathepsin B activity, K ؉ efflux, and reactive oxygen species production, were all required for the inflammasome activation triggered by M. canis. Meanwhile, Syk, Dectin-1, and Card9 were found to be involved in M. canis-induced IL-1␤ secretion via regulation of pro-IL-1␤ transcription. More importantly, our data revealed that M. canis-induced production of IL-1␤ was dependent on the NLRP3 inflammasome in vivo. Together, this study unveils that the NLRP3 inflammasome exerts a critical role in host innate immune responses against M. canis infection, and our data suggest that diseases that result from M. canis infection might be controlled by regulating the activation of inflammasomes.

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Epidemiologia e etiologia das dermatofitoses em Goiânia, GO, Brasil

Cited by 41 publications

References 5 publications

Formigas como veiculadoras de microrganismos em ambiente hospitalar

Formigas como veiculadoras de microrganismos em ambiente hospitalar

Identification of fungi species in the onychomycosis of institutionalized elderly

Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome

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