Toxoplasmose do sistema nervoso central em paciente sem evidência de imunossupressão: relato de caso

Silva, Luciana da; Vieira, Roseli Stone; Serafini, Luciano Neder; Carlotti, Carlos Gilberto; Figueiredo, José Fernando de Castro

doi:10.1590/s0037-86822001000500014

Cited by 13 publications

(11 citation statements)

References 4 publications

(2 reference statements)

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“…The microscopic lesions found were consistent to the ones reported by other authors which studied lesions in humans [7,9,11]. This study confirms the importance of T. gondii as a cause of active and severe lesion in the central nervous system.…”

Section: Discussionsupporting

confidence: 91%

“…The animals were accompanied for 60 days and, then, sacrificed by cervical dislocation. The macerated brain was reinoculated intraperitoneally in a second group of three BALB/c mice (2 nd inoculum) accordingly to pre-established protocol [9].…”

Section: Methodsmentioning

confidence: 99%

“…It is also found hemorrhage with erythrocytes displayed in the lesion periphery and in other encephalic regions [9].…”

mentioning

confidence: 89%

“…The main anatomopathological signals observed in human being brains infected with T. gondii, indicative of expansive lesion of the central nervous system, are: diffuse congestion and edema of the encephalic parenchyma and coagulative necrosis with varied sizes, in different evolutionary stages and scattered over the white and grey substances [9].…”

mentioning

confidence: 99%

“…In some regions, the blood irrigation is damaged blocking the circulating monocytes arrival, therefore the necrotic tissue is not phagocytized or eliminated, remaining in the region and, possibly, suffering calcification. In apparent older necrotic areas it is possible to distinguish edema and hemorrhage surrounding the lesion [9].…”

mentioning

confidence: 99%

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Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii

Silva¹,

Lino

Costa³

et al. 2008

Braz J Infect Dis

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Toxoplasmosis is one of the most important diseases of the nervous central system, leading to severe symptoms and, many times, irreversible sequelae. This work demonstrated the main anatomopathological lesions caused by Toxoplasma gondii in brains from experimentally infected BALB/c mice. We analyzed 51 cases of mice that developed toxoplasmosis after experimental infection by intraperitoneal inoculation of blood, amniotic liquid and cerebrospinal fluid from fetuses, newly born children and pregnant women with clinical and laboratory signals of toxoplasmosis. In all experiments where we detected the parasite in mice we also detected pathological lesions in the animal brains with great polymorphism between experiments. Edema was the most found lesion in all cases. Besides, it was possible to demonstrate the inflammatory process in 82.4% of cases and necrosis in 64.7% of cases, in agreement with the literature that describes severe neurological damage in its hosts.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

“…It is also found hemorrhage with erythrocytes displayed in the lesion periphery and in other encephalic regions [9].…”

mentioning

confidence: 89%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii

Silva¹,

Lino

Costa³

et al. 2008

Braz J Infect Dis

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Unusual cause of dementia in an immunocompetent host: toxoplasmic encephalitis

et al. 2009

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A 69-year-old male was presented with a 2-month history of cognitive decline. The most profound deficit was observed in short-term verbal and visual memory and recognition. He was otherwise healthy, apart from atrial fibrillation diagnosed 5 months before. Brain MRI revealed T2 hyperintensities in the left thalamus, right pulvinar thalami, both putamina and right head of caudate nucleus without diffusion restriction on DWI sequences. CSF examination revealed elevated proteins. He was HIV negative. The course of the disease was complicated with gram negative sepsis and the patient died 14 days later. Autopsy revealed the brain lesions to have been caused by toxoplasmic encephalitis. Toxoplasmic encephalitis is an extremely rare cause of rapidly progressive dementia in immunocompetent patients. In patients with multiple lesions, hyperintense on T2 and hypointense on T1 weighted sequences, without diffusion restriction and some expansive effect, infectious causes should be considered, even in the absence of classical signs of infectious diseases and CSF pleocythosis.

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Toxoplasmic meningoencephalitis in an immunocompetent host

Mahajan

Sharma

Kaushik

et al. 2005

Transactions of the Royal Society of Tropical Medicine and Hygi

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Central nervous system involvement due to toxoplasmosis in an immunocompetent host is very rare. We report a case of an immunocompetent patient who presented with suspected tuberculous meningoencephalitis but showed no clinical response to antitubercular therapy. Later, toxoplasmic meningoencephalitis was proved by positive serological testing for toxoplasmosis, supportive magnetic resonance imaging findings of the brain and a therapeutic response to co-trimoxazole and prednisolone. Therefore, toxoplasmosis should be considered in cases of suspected tuberculous meningoencephalitis that fail to respond to specific therapy.

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Toxoplasmose do sistema nervoso central em paciente sem evidência de imunossupressão: relato de caso

Cited by 13 publications

References 4 publications

Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii

Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii

Unusual cause of dementia in an immunocompetent host: toxoplasmic encephalitis

Toxoplasmic meningoencephalitis in an immunocompetent host

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