Retardo do crescimento em crianças com reação intradérmica positiva para leishmaniose: resultados preliminares

Cunha, Daniel Ferreira da; Lara, Vítor Carvalho; Monteiro, Jacqueline Pontes; Romero, Héctor Dardo; Cunha, Selma Freire de Carvalho da

doi:10.1590/s0037-86822001000100004

Cited by 4 publications

(3 citation statements)

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“…On the other hand, Viana et al [13] used both tests and did not observe any differences between the average age of positive and negative subjects. For studies which involved children only [32], [36], [44], [52], meta-analysis were not performed since the upper cut-off point was different between studies. In this case, no consistent patterns were identified in the results.…”

Section: Resultsmentioning

confidence: 99%

“…In order to evaluate the potential role of malnutrition on the risk of infection by L. infantum we selected four papers reporting results of five studies which compared eutrophic children and those with some degree of malnutrition [32], [36], [48], [52]. Figure 4 shows that the presence of malnutrition (although non-significantly) decreased the likelihood of diagnosis of asymptomatic infection.…”

Section: Resultsmentioning

confidence: 99%

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Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis

et al. 2013

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BackgroundStill today, more than 30 years after the beginning of the process of visceral leishmaniasis' urbanization, there is little knowledge about the risk factors for its occurrence, despite their relevance to the control and understanding of disease dynamics. The present study is the first systematic review with meta-analysis about factors associated with Leishmania infantum infection in humans in the Americas.Methods and FindingsAfter searching different databases, consultations to the reference lists of articles and to experts in the field, 51 studies were reviewed. Theoretical discussions or meta-analysis of p-values or of effect sizes were used to pool information about each variable. The Q test and the I2 statistic were used to assess heterogeneities among the studies. Male sex was associated with visceral leishmaniasis in studies which used the leishmanin skin test for diagnosis and in those where the outcome was the clinical disease; the opposite occurred when serological diagnosis was applied. Younger individuals were less frequently infected than adults, but were more prone to illness. Although with different levels of evidence and of heterogeneity, the presence of dogs at home, higher dog seropositivity in nearby areas, lower socioeconomic status and highly vegetated areas were associated with L. infantum infection. This was not noticed for the presence of chickens in the house and with nutritional status. Susceptibilities to bias and limitations in the analysis and in the description of results were often identified in the studies analyzed.ConclusionsResults showed the existence of consistent patterns for some of the factors analyzed and should be taken into account in developing more effective and well-targeted control measures. Studies must be conducted in new areas of the continent, with improved methodological quality and prioritizing the investigation of the patterns identified and their causes, as well as variables for which knowledge is poor.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis

et al. 2013

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“…During the leishmaniasis infection, the impaired immune system of the host may cause an uncontrolled parasite replication that delays the healing of CL leading to a diffuse CL, ML or VL [6]. Even though it has been shown that leishmaniasis may occur in individuals in endemic areas independently of the nutritional status [7], studies with children have shown a link between poor Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability 50 nutritional status, growth retardation and iron deficiency with CL [8,9]. Furthermore, malnourished children are at a greater risk for developing severe VL than well-nourished children [10].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Lazarte¹,

Alegre²,

Rojas³

et al. 2013

FNS

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Macro and micronutrient deficiencies are a significant problem among people in rural areas in developing countries. Deficiencies may lead to an impaired immune system making the organism vulnerable to infections and diseases. In this paper, the dietary intake, anthropometric measurements, zinc and copper levels in serum, of patients with cutaneous leishmaniasis (CL) are compared with a group of healthy controls and reference values. Results showed no significant differences in most nutrient intake or anthropometrics between patients and controls. However, serum zinc level of patients (80 μg/dl) was significantly lower (P < 0.001) than in controls (85 μg/dl), likely explained by the presence of leishmaniasis. The median serum zinc level in both groups was below the reference values, even though their median zinc intake met the zinc recommendations from WHO. Consequently, besides the presence of leishmaniasis, serum zinc levels may be compromised by inhibitory components in their diet, such as phytates, as it is shown by the molar ratio phytate:zinc (Phy:Zn) that was between 11 and 19, while 15 is the level said to compromise zinc status. There were significant (P < 0.05) negative correlations between serum zinc and Phy:Zn, for patients (r = −0.413) and controls (r = −0.410). In conclusion this study shows that patients with CL in Chapare, Bolivia had low serum zinc levels due to the leishmaniasis per se and the decreased zinc bioavailability in their diet. CL infection was not in direct association with the nutritional status indicated by the anthropometric or dietary assessments. However, dietary intake showed 5 essential nutrients below the nutrient recommendation in both groups.

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Interaction Between Nutrition and Metabolism

Barrouin‐Melo

Morejón-Terán

Anturaniemi

et al. 2018

Experientia Supplementum

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Retardo do crescimento em crianças com reação intradérmica positiva para leishmaniose: resultados preliminares

Cited by 4 publications

References 4 publications

Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis

Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Interaction Between Nutrition and Metabolism

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