Síndrome pulmonar e cardiovascular por Hantavirus: aspectos epidemiológicos, clínicos, do diagnóstico laboratorial e do tratamento

Abstract

The Hantavirus pulmonary and cardiovascular syndrome (HPCVS) is an emerging disease in Brazil. In this study, eight confirmed cases of HPCVS were studied. All the patients presented fever and dyspnea as well as thrombocytopenia and hypoxemia. Tachycardia, malaise, hypotension and lung rales occurred in 75 to 87.5% of the cases. Hemoconcentration, blood cell count increased and immature neutrophils, and high levels of creatinine were observed in 75 to 87.5%. Intravenous liquid infusion, the use of drugs for increasing systemic vascular resistance and inotropism, and mechanic ventilation were used for the patients. Mechanical ventilation and volume administration should be started precociously, preferable in intensive care units employing recommended universal and respiratory precautions. Careful volume administration should be limited if signs of pulmonary edema develop. Mortality (50%) is high and probably related to the severity of the disease as well as to a delayed attending of the patients for intensive management. It is important to report hantaviruses and HPCVS to the Brazilian medical community considering that many cases could be undiagnosed.

Hantavirus pulmonary syndrome in Uberaba, Minas Gerais, Brazil

“…In Ribeirão Preto, São Paulo, eight cases were reported during the last few years and in the Triângulo Mineiro Region, several cases were observed in Uberlândia and, more recently, in Uberaba (Figueiredo et al 2001, Ferreira et al 2001, Silva-Vergara et al 2001. We describe here the clinical-epidemiological profile of patients with HPS.…”

Circulation of hantaviruses in the influence area of the Cuiabá-Santarém Highway

“…105(5): 665-671, August 2010 Hantaviruses are the etiologic agents of the hantavirus pulmonary syndrome (HPS), a group of RNA viruses belonging to the family Bunyaviridae, genus Hantavirus (ICTV 2005). These viruses are transmitted to humans by inhalation of infected aerosols produced by dried wild rodent excrement (family Cricetidae: subfamily Sigmodontinae) (Lee et al 1981, OPAS 1999, Nichol 1999, Figueiredo et al 2001.…”

Análise preditiva da distribuição geográfica de hantavírus no Brasil

“…Em momentos de déficit alimentar ou em superpopulações, brigas são frequentes o que acarreta o contato com saliva ou excretas, assim mantendo as infecções em ciclos enzoóticos (Childs et al 1995, CDC, 1999, Figueiredo et al 2001). …”