Aplastic crisis caused by parvovirus B19 in an adult patient with sickle-cell disease

Setúbal, Sérgio; Gabriel, Adelmo Henrique Daumas; Nascimento, Jussara Pereira do; Oliveira, Solange Artimos de

doi:10.1590/s0037-86822000000500009

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…Sickle cell anemia, a disease characterized by high erythrocyte turnover to compensate for red cell lysis and chronic hemolytic anemia in afflicted patients[22], remains a public health concern in Nigeria[10]. Defining the risk of crisis and poor life expectancy in these patients is now a topmost priority in the research agenda of the country[23].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of parvovirus B19 antibodies and evidence of viremia among Nigerian patients with sickle cell anemia

Iwalokun¹,

Iwalokun²,

Hodonu³

2013

J Biomed Res

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Clinical, biochemical and molecular evidence for the sickle cell anemia (SCA) crisis in Nigerian patients arising from parvovirus b19 infection remains inadequate. This study determined the prevalence and correlates of anti-parvovirus b19 antibodies in a population of SCA patients and non-SCA healthy controls in Lagos, Nigeria. In this prospective cross-sectional study, we enrolled 73 confirmed SCA patients from 5 district hospitals in Lagos and 81 sex and age-matched non-SCA healthy controls. Serum sample from each study participant was screened for anti-parvovirus b19 by ELISA and PCR techniques. Standard biomedical assays were also done. Anti-parvovirus b19 IgM and IgG antibodies were detected in 22 (14.3%) and 97 (62.9%) of the 154 sera screened, 13 (17.8%) and 45 (61.6%) in SCA patients; 9 (11.1%) and 52 (64.2%) in non-SCA controls. The overall seronegativity rate was 19.5%. Parvovirus B19 DNA was found in 2 (11.1%) of the 18 IgM seropositive SCA serum samples screened. On the whole, parvovirus b19 infection was more commonly asymptomatic in non-SCA controls but caused significant elevation in liver enzymes in infected SCA patients (P < 0.05). The risk of acute parvovirus b19 infection increased 65 times during unsteady state among the SCA patients. Although no deaths of infected patients were recorded during the study, age below 12 years, hospitalization and overcrowded environment were risk factors for infection. We conclude that parvovirus b19 is common in SCA patients, incurring greater susceptibility to infections.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of parvovirus B19 antibodies and evidence of viremia among Nigerian patients with sickle cell anemia

Iwalokun¹,

Iwalokun²,

Hodonu³

2013

J Biomed Res

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“…Tests are available to confirm the diagnosis. Management includes packed red cell transfusions and, in cases of immunocompromised patients, administration of intravenous immunoglobulin [7] .…”

Section: Conclusion:-mentioning

confidence: 99%