Erupção papular prurítica associada ao vírus da imunodeficiência humana - Etiopatogênese avaliada por análise clínica, imuno-histoquímica e ultra-estrutural

Ramos, Heloisa

doi:10.1590/s0037-86821999000200014

Cited by 2 publications

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“…RNA is a predictor of the degree of immunodeficiency, irrespective of the CD 4 + T lymphocyte counts. 7,[14][15][16] The use of highly effective antiretroviral medicines (or Highly Active Antiretroviral Therapy -HAART) since 1995, has triggered changes in the presentation and course of the dermatoses in those infected by a retrovirus and can promote the disappearance of cutaneous lesions and prevent more serious opportunist diseases, following a partial recovery of the immunological system. 17 The present study was performed at the Hospital Giselda Trigueiro, in Natal/RN, a reference center for infectious and contagious diseases in the capital and that registered 66.3% of the Aids notifications in the state from January 1983 to August 2000.…”

Section: + Helper Cells Count In the Peripheral Blood Is A Laboratorimentioning

confidence: 99%

Perfil epidemiológico de infectados pelo vírus HIV com dermatoses em Natal/RN

Cardoso

Ramos

Lôbo

2003

An. Bras. Dermatol.

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FUNDAMENTOS: Não há registro de dermatoses em infectados pelo vírus HIV no Rio Grande do Norte, embora haja 899 casos acumulados de AIDS em adultos entre janeiro de 1983 e agosto de 2000 e coeficientes de mortalidade por cem mil habitantes de 3,80 e 2,47, nos anos de 1995 e 1997, respectivamente, coincidindo essa diferença de valores, com o uso de antiretrovirais. OBJETIVOS: Descrever as características epidemiológicas de infectados, a freqüência de dermatoses e suas gravidades em usuários e não usuários de antiretrovirais. MÉTODOS: Foram incluídos 172 pacientes conforme a classificação do CDC/1992; descrevendo-se o uso de antiretrovirais e dermatoses neles presentes. RESULTADOS: A amostra teve 83,72% de homens, com média de idade de 37,17 anos, contaminados por via sexual (96,5%), heterossexuais predominantes (54,7%). As doenças cutâneas mais freqüentes foram as virais, fúngicas e miscelânia. O percentual médio da pele atingida pelas dermatoses foi 12,5%. A média da carga viral foi 109.114,05 cps/ml, e a de linfócitos T CD4+ foi 383,15 céls/mm³, estando 81,4% destes, em uso de antiretrovirais. CONCLUSÕES: O perfil epidemiológico dos infectados pelo vírus HIV no RN não difere das outras regiões brasileiras. Estudos analíticos que minimizem bias de confusão são necessários para aferir o grau de interferência do uso de antiretrovirais nesses indivíduos.

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Section: + Helper Cells Count In the Peripheral Blood Is A Laboratorimentioning

confidence: 99%

Perfil epidemiológico de infectados pelo vírus HIV com dermatoses em Natal/RN

Cardoso

Ramos

Lôbo

2003

An. Bras. Dermatol.

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HIV-Associated Pruritus

Singh

Rudikoff

2003

American Journal of Clinical Dermatology

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With the advent of highly active antiretroviral therapy (HAART), life-threatening opportunistic infection has become less common in patients with HIV infection and longevity has increased dramatically. With increased longevity, the problems of living with a chronic disease have become more prominent in this patient population. Disorders such as fat redistribution and metabolic abnormalities can result from antiviral medications and from HIV disease itself. Pruritus is one of the most common symptoms encountered in patients with HIV. The spectrum of skin diseases in such patients encompasses dermatoses of diverse etiologies; a few are peculiar to patients with HIV while others are not. Some of these conditions may cause severe and sometimes intractable pruritus that provokes scratching, picking, disfigurement, sleep loss, and significant psychological stress. Moreover, the expense of ongoing medical treatments can be daunting. Skin rash can sometimes be the initial presentation of HIV infection or serve as a harbinger of disease progression. Causes of pruritus include skin infections, infestations, papulosquamous disorders, photodermatitis, xerosis, drug reactions, and occasionally lymphoproliferative disorders. Drug eruptions are particularly common in patients who are HIV positive, presumably as a result of immune dysregulation, altered drug metabolism, and polypharmacy. Itching can also result from systemic diseases such as chronic renal failure, liver disease, or systemic lymphoma. Workup of pruritus should include a careful examination of the skin, hair, nails, and mucous membranes to establish a primary dermatologic diagnosis. If no dermatologic cause is found, a systemic cause or medication-related etiology should be sought. Idiopathic HIV pruritus is a diagnosis of exclusion and should only be considered when a specific diagnosis cannot be established. The management of HIV-associated pruritus should be directed at the underlying condition. Phototherapy has been found to be useful in the treatment of several HIV-associated dermatoses and idiopathic pruritus as well. Unfortunately, some of the treatments that have been suggested for patients with HIV are anecdotal or based on small uncontrolled studies. The last decade has seen a surge in the utilization of HAART which, to some degree, reconstitutes the immune system and ameliorates some dermatologic diseases. On the other hand, some skin diseases flare temporarily when HAART is started. Unless frank drug allergy is suspected, HAART does not need to be stopped.

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Erupção papular prurítica associada ao vírus da imunodeficiência humana - Etiopatogênese avaliada por análise clínica, imuno-histoquímica e ultra-estrutural

Cited by 2 publications

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Perfil epidemiológico de infectados pelo vírus HIV com dermatoses em Natal/RN

Perfil epidemiológico de infectados pelo vírus HIV com dermatoses em Natal/RN

HIV-Associated Pruritus

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