Edema na hanseníase: aspectos clínicos e terapêuticos

Valentini, Attilio; Nery, José A. C.; Salles, Ana Maria; Vieira, Letícia; Sarno, Euzenir Nunes

doi:10.1590/s0037-86821999000200003

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…These ulcers should be differentiated from those of Lucio's phenomenon, necrotic cutaneous vasculitis 40 . In HD, oedema of the lower legs, mostly bilateral and more evident in the evening, may precede by months or even years the appearance of the more typical skin lesions 25,41 . This phenomenon is different from oedema of face, hands and/or feet that can happen in HD in the context of reactions 42…”

Section: Discussionmentioning

confidence: 95%

“…40 In HD, oedema of the lower legs, mostly bilateral and more evident in the evening, may precede by months or even years the appearance of the more typical skin lesions. 25,41 This phenomenon is different from oedema of face, hands and/or feet that can happen in HD in the context of reactions. 42 There are several case reports mentioning lepromatous lymphadenopathy masquerading as other diseases, such as lymphoma.…”

Section: Awareness Of Hd and Early Diagnosismentioning

confidence: 99%

“…42 There are several case reports mentioning lepromatous lymphadenopathy masquerading as other diseases, such as lymphoma. 41 In several textbooks, leukaemia and lymphomas are mentioned in the differential diagnosis of LL disease. 25,43 Lymphadenopathy in HD is usually associated with episodes of reaction, especially in LL disease.…”

Section: Awareness Of Hd and Early Diagnosismentioning

confidence: 99%

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Hansen's disease in a general hospital: uncommon presentations and delay in diagnosis

Nery

Schreuder²,

Mattos

et al. 2009

Acad Dermatol Venereol

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Multibacillary (MB) HD, especially close to the lepromatous end of the spectrum, may mimic other diseases, and the patient can not be diagnosed without a biopsy or a slit skin smear examination. Clinicians working in a HD endemic area (Rio de Janeiro) do not always include HD in their differential diagnosis, especially when the clinical presentation is unusual. HD should be considered in all patients with skin lesions not responding to treatment, especially when they have neurological deficits, and live or have lived in an HD endemic area. Due to the increase in global travel and immigration, doctors in low endemic areas need to consider HD as a possible diagnosis.

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Section: Discussionmentioning

confidence: 95%

Section: Awareness Of Hd and Early Diagnosismentioning

confidence: 99%

Section: Awareness Of Hd and Early Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Hansen's disease in a general hospital: uncommon presentations and delay in diagnosis

Nery

Schreuder²,

Mattos

et al. 2009

Acad Dermatol Venereol

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“…Ocorrem lesões eritematosas com formações de vesículas, bolhas, evoluindo muitas vezes para ul- cerações. Manifestações sistêmicas como febre, adenomegalia, perda de peso, artralgia, mialgia, dor e sensibilidade dos nervos podem ocorrer 29 .…”

Section: A Influência Da Talidomida Na Manifestação Do Eritema Nodosounclassified

“…O TNF alfa, assim como a IL1, são citocinas inflamatórias com ação sinérgica sobre o endotélio capilar, levando a um aumento na permeabilidade durante a reação inflamatória in vivo e ensaios in vitro. A talidomida é o fármaco de escolha com efeito terapêutico excelente nas reações tipo II, porém com indicação limitada em mulheres em idade fértil devido à elevada teratogenicidade 29 . Reduz a produção de TNF alfa 30 através do bloqueio do RNA mensageiro que comanda a produção desta citocina, o que poderia explicar o seu efeito no ENL 33 .…”

Section: A Influência Da Talidomida Na Manifestação Do Eritema Nodosounclassified

Talidomida: novas perspectivas para utilização como antiinflamatório, imunossupressor e antiangiogênico

Borges¹,

Fröehlich²

2003

Rev. Assoc. Med. Bras.

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The new uses of thalidomide are reviewed. It has recently been used as antinflammatory, immunosuppressive, antiangiogenic, and antiviral agent. Although its mechanism of action is not yet understood, the advantage of its use in several diseases, such as erythema nodosum leprosum, multiple myeloma, and graft-versus-host-disease is evident. Owing to its teratogenic properties, the use of thalidomide must be very well controlled. However, thalidomide has become a very important alternative, with new applications being studied.

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