Ulcera cutanea provocada por hongos del genero Fusarium

Negroni, Ricardo; Martino, Olindo; Robles, Ana María; Orduña, Tomás; Arechavala, Alicia; Brusca, Silvia; Helou, Silvia

doi:10.1590/s0037-86821997000400008

Cited by 5 publications

(2 citation statements)

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“…In immunocompetent individuals, this microorganism is mainly associated with fungal keratitis, 11 cutaneous ulcers, 12 and onychomycosis 13,14 . In these patients, Nucci and Anaissie 6 reported the occurrence of inflammation, with an abundance of neutrophils, and variable necrosis associated with the presence of the fungus in histopathologic analyses of skin.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 In these patients, infection by Fusarium may manifest itself in the skin by a variety of lesions, with the most frequent being erythematous papules and nodules with central necrosis. 2,9,10 In immunocompetent individuals, this microorganism is mainly associated with fungal keratitis, 11 cutaneous ulcers, 12 and onychomycosis. 13,14 In these patients, Nucci and Anaissie 6 reported the occurrence of inflammation, with an abundance of neutrophils, and variable necrosis associated with the presence of the fungus in histopathologic analyses of skin.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic extract of Fusarium oxysporum induces histopathologic alterations and apoptosis in the skin of Wistar rats

et al. 2009

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Background Most patients with Fusarium infection present with affection of the tegumentary system, with the presence of necrotic and/or inflammatory lesions associated with pain. Aim To evaluate the effect of the intradermal application of a metabolic extract of Fusarium oxysporum in the skin of Wistar rats. Methods The extract was obtained from fungal cultivation in Czapek‐Dox medium. It was sterilized by filtration through a Millipore membrane, and injected (0.5 mg/mL) intradermally into the skin of rats, which were killed 3, 6, 12, and 24 h after inoculation. Skin specimens were placed in paraffin and stained using hematoxylin and eosin, and toluidine blue, for the evaluation of the inflammatory response, and Sirius red for the quantification of collagen. Terminal deoxynucleotidyl transferase‐mediated UTP nick end labelling (TUNEL) was used for the identification of apoptosis. Tissue reactions were graded and compared over time and compartment. Results The inflammatory reaction reached a peak at 12 h for both the dermis and subcutaneous region, being graded as moderate and moderate to severe, respectively. There was an influx of granulocytes, lymphocytes, and macrophages. A significant increase in the number of mast cells, as well as the presence of hyperemic vessels and apoptotic bodies, was observed. There was TUNEL staining in keratinocytes, fibroblasts, endothelial cells, muscles, and in the cells of the inflammatory infiltrate. There was a significant decrease in the area occupied by collagen after 12 h. Conclusions The extract induced histopathologic alterations in the skin, probably as a result of the presence of active toxic metabolites.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolic extract of Fusarium oxysporum induces histopathologic alterations and apoptosis in the skin of Wistar rats

et al. 2009

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A Case of Primary Localized Cutaneous Infection Due to Fusarium oxysporum

et al. 2010

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Fusarium is a ubiquitous hyalohyphomycete isolated from food, widespread in the environment (plants, soil) and present at all latitudes. Fusarium oxysporum and Fusarium solani are the most frequent pathogenic species, followed by F. moniliforme and F. chlamydosporum. Infections due to this mold may be disseminated or localized. Localized forms include cutaneous and subcutaneous infection, onychomycosis, endophtalmitis, otitis, sinusitis, arthritis, osteomyelitis, and brain abscess. Disseminated forms are those in which two or more noncontiguous sites may be involved. These latter are observed in patients with severe neutropenia. Wounds, digital ulcers, onychomycosis, and paronychia are the typical cutaneous portal of entry. We report a case of primary localized cutaneous infection due to Fusarium in a 29-year-old woman presenting with a nodular lesion, partially ulcerated, asymptomatic on the first finger of the left hand, appeared 4 months earlier. Histological examination showed spongiosis and acanthosis in the stratum corneum, ulceration and inflammation with prevalently mononucleate cells and septate and branched fungal structures in the epidermis and in dermis. The fungus was identified as Fusarium oxysporum by culture of biopsy fragments on Sabouraud dextrose agar with chloramphenicol. The culture was deposited in the culture collection of the mycology section of IHEM, Brussels (IHEM21984 col no. 125). The patient had normal immune status and was successfully treated with surgical excision. Recovery was confirmed at follow-up 8 months later.

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