Uso de tártaro emético tópico na leishmaniose cutânea

Romero, Gustavo; Vela, Julia S.A.; Marsden, Philip D.

doi:10.1590/s0037-86821996000400012

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Drug Development Paradigm2

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2021

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“…80,81 Excipients and formulations can influence the particle size, physical form, solubility and stability of the API thus impacting drug uptake and/or permeability across biological barriers and eventually efficacy and toxicity of the overall product. 80 The earliest reports of topical treatment of tegumentary leishmaniasis date back to the 1920s describing the use of the trivalent antimony tartar emetic 82,83 and the pentavalent stibosan. Other harsh chemicals were applied to the skin to combat the parasite including ointments consisting of sulphuric acid and charcoal (9 : 1).…”

Section: Drug Development and Formulationmentioning

confidence: 99%

“…The earliest reports of topical treatment of tegumentary leishmaniasis date back to the 1920s describing the use of the trivalent antimony tartar emetic 82,83 and the pentavalent stibosan. Other harsh chemicals were applied to the skin to combat the parasite including ointments consisting of sulphuric acid and charcoal (9 : 1).…”

Section: Drug Development Paradigmmentioning

confidence: 99%

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