Delayed skin healing of cutaneous leishmaniasis after clinical cure of mucosal surfaces

Romero, Gustavo; Lessa, Hélio A.; Macêdo, Vanize; Carvalho, Edgar M.; Marsden, Philip D.

doi:10.1590/s0037-86821996000300012

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…An extensive remodeling process involving fibroblasts and macrophages has been described in the early leishmaniasis lesion (11). Moreover, abnormalities in wound healing have been noted in patients treated for cutaneous leishmaniasis (26).…”

Section: Discussionmentioning

confidence: 99%

The wound repair response controls outcome to cutaneous leishmaniasis

Sakthianandeswaren

Elso

Simpson

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated lmr1, -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically important for the rapid cure in murine cutaneous leishmaniasis caused by Leishmania major. Mice congenic for leishmaniasis resistance loci, which cured their lesions more rapidly than their susceptible parents, also expressed differentially genes involved in tissue repair, laid down more ordered collagen fibers, and healed punch biopsy wounds more rapidly. Fibroblast monolayers from these mice repaired in vitro wounds faster, and this process was accelerated by supernatants from infected macrophages. Because these effects are independent of T cell-mediated immunity, we conclude that the rate of wound healing is likely to be an important component of innate immunity involved in resistance to cutaneous leishmaniasis.fibroblasts ͉ leishmania ͉ macrophages ͉ resistance ͉ wound healing

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Section: Discussionmentioning

confidence: 99%