Infecção gástrica por Helicobacter pylori em pacientes sintomáticos da Ilha de São Luís, MA: correlação endoscópica, anatomopatológica e microbiológica

Abstract

With previously defined criteria of inclusion and previous consent, twenty six consecutive patients (19 to 64 years old), with upper digestive symptoms, were submitted to endoscopy, with biopsy, constant of eight samples of the antropyloric region (four of the anterior aspect and four of the posterior aspect). Two samples were been for culture; two for free urease test, two for smears; all gathered in adequate transport medium over refrigeration. Two samples immersed in formaline to 10% for histopathologic exam. 25/26 (96%) of the patients showed infection by H. pylori by means of one or more methods utilized. In 16/26 (61%), alterations were observed in endoscopy (gastric inflammation in eleven, peptic ulcer in two and ulcer scars in three cases). Of the patients with endoscopic gastric inflammation, presented positive as well as all (100%) bearers of scar or peptic ulcer. A close relationship was observed between the presence of H. pylori and chronic gastric inflammation 24/25 (96%). Histopathologic slices stained by hematoxilin-eosin was the test of highest diagnostic sensitivity 24/25 (96%), followed by urease test 23%25 (92%), stained smears 19/25 (76%) and culture 18/25 (72%). Our conclusion is that the prevalence of gastric infection for H. pylori in symptomatic patients is high, correlated with chronic gastric inflammation and ulcers. Histopathologic slices stained by hematoxilin-eosin and free urease test are the most sensitive indicators of the presence of H. pylori. This study should proceed for further elucidation of questions realised and include a control group of symptomatics individuals paired for sex and age.

Evidence of mother-child transmission of Helicobacter pylori infection

“…Size of the sample was influenced by some factors. We included only family members with blood collected from more than 2/3 of the family members, but have to consider that those who show up for blood collection tend to be those who are symptomatic or with peptic disease and thus are more probable to be H. pylori+ (8,50,57) . Patients who already underwent endoscopic examination were excluded with the purpose of avoiding a possible contamination by the endoscopy apparatus.…”

Avaliação da deficiencia de ferro em pacientes infectados com Helicobacter Pylori

“…Estes dados são similares aos encontrados por Coelho et al, [48] em adultos sintomáticos na mesma cidade. Em outros estudos brasileiros em diversas regiões, encontraram as seguintes prevalências da infecção pelo H. pylori: 59,5% no Rio de Janeiro (RJ) [49]; 83% em Santa Maria (RS) [50]; 84,7% em Nossa Senhora do Livramento (MT) [51]; 89,6% em Campinas (SP) [52] e 96% em São Luís (MA) [53].…”