Utilização do tubo em "T" de silicone para tratamento de um caso de leishmaniose tegumentar americana com traqueomalácia

Amato, Valdir Sabbaga; Boulos, Maria Ivete Castro; Neto, Vicente Amato; Filomeno, Luiz Tareisio Brito

doi:10.1590/s0037-86821995000200008

Cited by 14 publications

(3 citation statements)

References 2 publications

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“…Nasal involvement can be responsible for changes in the drainage of the paranasal sinuses, leading to chronic sinusitis in addition to late facial disfigurement due to the destruction of the nasal septum [7]. In more severe cases that involve the pharynx and/or larynx, aspiration or airway obstruction can be a life-threatening consequence for the patient [8], [9].…”

Section: Introductionmentioning

confidence: 99%

Facial Structure Alterations and Abnormalities of the Paranasal Sinuses on Multidetector Computed Tomography Scans of Patients with Treated Mucosal Leishmaniasis

et al. 2014

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Background/ObjectivesMucosal leishmaniasis (ML) is a progressive disease that affects cartilage and bone structures of the nose and other upper respiratory tract structures. Complications associated with ML have been described, but there is a lack of studies that evaluate the structural changes of the nose and paranasal sinuses in ML using radiological methods. In this study, we aimed to assess the opacification of the paranasal sinuses in patients with treated ML and any anatomical changes in the face associated with ML using multidetector computed tomography scans (MDCT) of the sinuses. We compared the findings with a control group.Methodology/Principal FindingsWe evaluated 54 patients with treated ML who underwent CT scans of the sinuses and compared them with a control group of 40 patients who underwent orbital CT scans. The degree of sinus disease was assessed according to the Lund-Mackay criteria. Forty of the 54 patients with a history of ML (74.1%) had a tomographic score compatible with chronic sinusitis (Lund-Mackay ≥4). CT scans in the leishmaniasis and control groups demonstrated significant differences in terms of facial structure alterations. Patients from the ML group showed more severe levels of partial opacification and pansinus mucosal thickening (42.6%) and a greater severity of total opacification. Patients from the ML group with a Lund-Mackay score ≥4 presented longer durations of disease before treatment and more severe presentations of the disease at diagnosis.Conclusion/SignificanceCT scans of the sinuses of patients with ML presented several structural alterations, revealing a prominent destructive feature of the disease. The higher prevalence in this study of chronic rhinosinusitis observed in CT scans of patients with treated ML than in those of the control group suggests that ML can be considered a risk factor for chronic rhinosinusitis in this population (p<0.05).

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Section: Introductionmentioning

confidence: 99%

Facial Structure Alterations and Abnormalities of the Paranasal Sinuses on Multidetector Computed Tomography Scans of Patients with Treated Mucosal Leishmaniasis

et al. 2014

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“…Fortunately, less than 5% of the individuals infected with L. braziliensis may progress to mucosal leishmaniasis (ML), which results in ulceration of oropharynx and nasal mucosa either at the time of primary skin lesion or several months or years later [5]. The natural history of ML consists in the progressive destruction of the nasal septa and soft and hard palates, eventually causing severe facial disfiguration and respiratory disturbances that do not heal spontaneously [6]. Moreover, 22–50% of the individuals with ML are unresponsive to the current antimonial therapy and have an associated increase in morbidity and mortality [7].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Patterns from Primary Cutaneous Leishmania braziliensis Infections Associate with Eventual Development of Mucosal Disease in Humans

et al. 2012

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IntroductionLocalized Cutaneous Leishmaniasis (LCL) and Mucosal Leishmaniasis (ML) are two extreme clinical forms of American Tegumentary Leishmaniasis that usually begin as solitary primary cutaneous lesions. Host and parasite factors that influence the progression of LCL to ML are not completely understood. In this manuscript, we compare the gene expression profiles of primary cutaneous lesions from patients who eventually developed ML to those that did not.MethodsUsing RNA-seq, we analyzed both the human and Leishmania transcriptomes in primary cutaneous lesions.ResultsLimited number of reads mapping to Leishmania transcripts were obtained. For human transcripts, compared to ML patients, lesions from LCL patients displayed a general multi-polarization of the adaptive immune response and showed up-regulation of genes involved in chemoattraction of innate immune cells and in antigen presentation. We also identified a potential transcriptional signature in the primary lesions that may predict long-term disease outcome.ConclusionsWe were able to simultaneously sequence both human and Leishmania mRNA transcripts in primary cutaneous leishmaniasis lesions. Our results suggest an intrinsic difference in the immune capacity of LCL and ML patients. The findings correlate the complete cure of L. braziliensis infection with a controlled inflammatory response and a balanced activation of innate and adaptive immunity.

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“…No Brasil, a doença é um grande problema de saúde pública, devido a sua grande distribuição demográfica e ao grau de morbidade ocasionada pelas suas formas cutânea ou cutâneo-mucosa 12 . Quando a LTA é ocasionada pela Leishmania (Viannia) braziliensis pode ocorrer acometimento de mucosas, incluindo faringe, laringe e traquéia, podendo ocasionar a morte do paciente por aspiração ou insuficiência respiratória 1 . Este relato de caso trata-se de uma paciente com leishmaniose cutâneo-mucosa (LCM), que apresentou resposta terapêutica a pequena dose de antimonial pentavalente e antecedente de falha ao tratamento prolongado com alopurinol.…”

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Um caso de leishmaniose cutâneo-mucosa tratado com sucesso com baixa dose de antimonial pentavalente

Amato

Oliveira

Silva

et al. 1998

Rev. Soc. Bras. Med. Trop.

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The authors report a case of a 89 years-old woman with mucocutaneous leishmaniasis and previous diabetes mellitus and high blood pressure, who had been treated with allopurinol for 10 months without healing of lesions. Afterwards, she has been treated with meglumine antimonate, "glucantime" for 4 days, with a total dose 2,380 mg of Sbv, but developed cardiac side effects and hypokalemia, hence the treatment was withdrawn. However, this patient developed total clinical regression of lesions, in spite of she has been received low dose of this drug.

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Utilização do tubo em "T" de silicone para tratamento de um caso de leishmaniose tegumentar americana com traqueomalácia

Cited by 14 publications

References 2 publications

Facial Structure Alterations and Abnormalities of the Paranasal Sinuses on Multidetector Computed Tomography Scans of Patients with Treated Mucosal Leishmaniasis

Facial Structure Alterations and Abnormalities of the Paranasal Sinuses on Multidetector Computed Tomography Scans of Patients with Treated Mucosal Leishmaniasis

Transcriptome Patterns from Primary Cutaneous Leishmania braziliensis Infections Associate with Eventual Development of Mucosal Disease in Humans

Um caso de leishmaniose cutâneo-mucosa tratado com sucesso com baixa dose de antimonial pentavalente

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