Fulminant hepatitis with microvesicular steatosis (a histologic comparison of cases occurring in Brazil - Labrea hepatitis - and in central Africa - Bangui hepatitis)

Abstract

Z ilton A. A ndrade, Jean L. Lesbordes, Paul Ravisse, Raim undo P araná, Aluízio P rata, João S. Barberino and C hristian Trepo A similar histopathologic picture o f fa ta l hepatitis associated with widespread acute fa tty changes in hepatocytes and single-cell necrosis was seen in epidemic cases occurring in two distinct equatorial areas having high prevalençes ofH B V and HDV infections. The cases were previously considered to be two different entities; Labrea hepatitis in Brazil, and Bangui hepatitis in the Central African Republic. However, the histopathologic findings suggest that they are pathogenetically and etiologically related to H B V and HDV infections, probably modified by som e as y e t unknown fa cto r (s) presen t in equatorial fo re st zones.

HDV Genotypes in the Western Brazilian Amazon Region: A Preliminary Report

“…Most cases were related to HBV/HDV co-infection or superinfection. 17,18 HDV infections have also been described in other Western Amazonia countries such as Peru, Venezuela, and Equator, 7,19,20 also in isolated Amerindian populations. Cases of severe hepatitis in Peru and Venezuela have been correlated with infection by HDV genotype III.…”

Treatment of hepatitis delta virus genotype 3 infection with peg-interferon and entecavir

“…The histopathological technique consisted of serial histological sections stained with hematoxylin-eosin, complemented with separate sections stained with the following special stains: PAS (periodic acid-Schiff) with diastase, reticulin, picrosirius, Perls, and orcein. 24 The material collected was satisfactory for 18 patients. The liver biopsy results of these 18 patients were reviewed according to the METAVIR classification, 25 which is able to evaluate the different degrees of inflammation and fibrosis.…”

Animal models are reliably mimicking human diseases? A morphological study that compares animal with human NAFLD

“…These two morphologies were similar to severe microvesicular steatosis or severe macrovesicular steatosis in fatty human liver. According to Oleszczuk et al there are evidences that microvesicular steatosis indicates a worse hepatic injury than the macrovesicular one (Andrade et al, ). This experimental study showed that hepatocytes with macrovesicular steatosis had more effective regenerative capacity than those with microvesicular steatosis, confirming that the latter has a less favorable prognosis.…”