Parasitological diagnosis of mucocutaneous leishmaniasis due to Leishmania b. braziliensis in Bolivia

Dimier-David, L.; David, C.; Ravisse, P.; Bustillos, R; Revollo, Susana; Lyevre, P.; Muñoz, M; Vargas, Fernando; Dedet, Jean-Pierre

doi:10.1590/s0037-86821991000400005

Cited by 10 publications

(8 citation statements)

References 5 publications

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“…The sensitivity of this technique can be highly variable, depending on the number and dispersion of parasites in biopsy samples. Hence, parasite isolation success from MCL patients is especially low, due to the scarce numbers of parasites in mucosal lesions (Dimier-David et al, 1991a;Lopez et al, 1993). Successful culture of the Leishmania isolate is also dependent on the culture media (e.g.…”

Section: Advances In Diagnosismentioning

confidence: 99%

The epidemiology and control of leishmaniasis in Andean countries

et al. 2000

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This paper reviews the current knowledge of leishmaniasis epidemiology in Venezuela, Colombia, Ecuador, Peru, and Bolivia. In all 5 countries leishmaniasis is endemic in both the Andean highlands and the Amazon basin. The sandfly vectors belong to subgenera Helcocyrtomyia, Nyssomiya, Lutzomyia, and Psychodopygus, and the Verrucarum group. Most human infections are caused by Leishmania in the Viannia subgenus. Human Leishmania infections cause cutaneous lesions, with a minority of L. (Viannia) infections leading to mucocutaneous leishmaniasis. Visceral leishmaniasis and diffuse cutaneous leishmaniasis are both rare. In each country a significant proportion of Leishmania transmission is in or around houses, often close to coffee or cacao plantations. Reservoir hosts for domestic transmission cycles are uncertain. The paper first addresses the burden of disease caused by leishmaniasis, focusing on both incidence rates and on the variability in symptoms. Such information should provide a rational basis for prioritizing control resources, and for selecting therapy regimes. Secondly, we describe the variation in transmission ecology, outlining those variables which might affect the prevention strategies. Finally, we look at the current control strategies and review the recent studies on control.

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Section: Advances In Diagnosismentioning

confidence: 99%

The epidemiology and control of leishmaniasis in Andean countries

et al. 2000

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“…3,7 The Montenegro intradermal reaction is even today the most widely used method for the diagnosis of ACL. 8,9 This reaction has a high predictive value, being positive in over 90% of leishmaniasis cases. 10 Other laboratory tests such as smear, culture, inoculation in hamster, histopathological examination, indirect immunofluorescence and polimerase chain reaction (PCR) are also employed in order to increase diagnostic accuracy.…”

Section: Introductionmentioning

confidence: 99%

Estudo clínico, epidemiológico e terapêutico de 402 pacientes com leishmaniose tegumentar americana atendidos no Hospital Universitário de Brasília, DF, Brasil

Name

Borges

Nogueira

et al. 2005

An. Bras. Dermatol.

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BACKGROUND -American cutaneous leishmaniasis is a disease with high prevalence and incidence in Brazil. The Brazilian Central-Western Region currently holds the third largest incidence and the first growth rate of this disease in the country. OBJECTIVES -to evaluate clinical, epidemiological and treatment features of patients with American cutaneous leishmaniasis seen at the University Hospital of Brasília. METHOD -a case series study with 402 patients was carried out, spanning the period between January 1st, 1994 and February 28th, 2003. The following variables were studied: sex, age, occupation, state of origin, clinical features, diagnostic techniques, treatment with pentavalent antimony and side effects. Follow-up was one year after the end of treatment. RESULTS -the predominant group of patients was composed by male rural laborers who presented mainly the cutaneous form of the illness. The greatest efficacy of the antimony was observed in patients presenting the cutaneous form treated up to six months after the onset of symptoms, and in females in general (both differences were statistically significant in multivariate analysis). The early treatment of the mucocutaneous form also presented better results, although not statistically significant. Electrocardiographical alterations were more frequent in the group of patients receiving a 20mg SbV/Kg/day for a 30-day schedule than those with the same dosage for 20 days. Eosinophilia was found in 17.5%. CONCLUSIONS -Early treatment, female gender and cutaneous form presented higher levels of cure. Electrocardiographic changes rose as time of treatment was increased. The remarkable report of eosinophilia as a side effect of N-methylglucamine deserves further investigation. Keywords: Leishmaniasis, Mucocutaneous/diagnosis; Leishmaniasis, Mucocutaneous/epidemiology; Leishmaniasis, Mucocutaneous/therapy Resumo: FUNDAMENTOS -A leishmaniose tegumentar americana é doença em expansão no Brasil. A região Centro-Oeste é hoje a terceira em incidência e a primeira em crescimento da doença. OBJETIVOS -Avaliar pacientes com leishmaniose tegumentar americana atendidos no Hospital Universitário de

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“…2003). Diagnosis is based on directly evidencing the parasite in the lesions through microscopical examinations of Giemsa‐stained smears (Dimier‐David et al. 1991) and/or in demonstration the parasite in in vitro cultures and/or by PCR methods (Lopez et al.…”

Section: Introductionmentioning

confidence: 99%

Control of mucocutaneous leishmaniasis, a neglected disease: results of a control programme in Satipo Province, Peru

Guthmann¹,

Arlt

Garcia

et al. 2005

Tropical Med Int Health

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SummaryMucocutaneous leishmaniasis (MCL) is an important health problem in many rural areas of Latin America, but there are few data on the results of programmatic approaches to control the disease. We report the results of a control programme in San Martin de Pangoa District, which reports one of the highest prevalences of MCL in Peru. For 2 years (2001)(2002), the technicians at the health post were trained in patient case management, received medical support and were supplied with antimonials. An evaluation after 2 years showed the following main achievements: better diagnosis of patients, who were confirmed by microscopy in 34% (82/240) of the cases in 2001 and 60% of the cases (153/254) in 2002; improved follow-up during treatment: 237 of 263 (90%) patients who initiated an antimonial therapy ended the full treatment course; improved follow-up after treatment: 143 of 237 (60%) patients who ended their full treatment were correctly monitored during the required period of 6 (cutaneous cases) or 12 (mucosal cases) months after the end of treatment. These achievements were largely due to the human and logistical resources made available, the constant availability of medications and the close collaboration between the Ministry of Health, a national research institute and an international non-governmental organization. At the end of this period, the health authorities decided to register a generic brand of sodium stibogluconate, which is now in use. This should allow the treatment of a significant number of additional patients, while saving money to invest in other facets of the case management.

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Parasitological diagnosis of mucocutaneous leishmaniasis due to Leishmania b. braziliensis in Bolivia

Cited by 10 publications

References 5 publications

The epidemiology and control of leishmaniasis in Andean countries

The epidemiology and control of leishmaniasis in Andean countries

Estudo clínico, epidemiológico e terapêutico de 402 pacientes com leishmaniose tegumentar americana atendidos no Hospital Universitário de Brasília, DF, Brasil

Control of mucocutaneous leishmaniasis, a neglected disease: results of a control programme in Satipo Province, Peru

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