Bacteriological evaluation of wounds in seriously burned hospitalized patients

Silva, Sueli de Lourdes Nogueira Vilela; Macedo, Oswaldo Gontijo; Damasceno, Carlos Américo Veiga; Carvalho, Maria Auxiliadora Roque de; Cisalpino, E. O.

doi:10.1590/s0037-86821991000300007

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…35 There have been other reports of possible melioidosis from Brazil, including isolation of B. pseudomallei from burns patients, but these lacked detail on disease presentation, exposure, or corroborating evidence. 36 There have been reports of sporadic human melioidosis from other parts of Central America. [37][38][39][40] More recently, there have been occasional reports of melioidosis diagnosed unexpectedly after presumed exposure in parts of South or Central America not previously known to be endemic for the disease.…”

Section: Latin Americamentioning

confidence: 99%

Melioidosis in the Americas

Inglis¹,

Rolim²,

SOUSA³

2006

The American Journal of Tropical Medicine and Hygiene

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Melioidosis is a potentially severe bacterial infection caused by Burkholderia pseudomallei. There has been growing awareness of the disease in the Americas, particularly since the Vietnam conflict when it was diagnosed in returning service personnel. Accidental laboratory exposure indicates the difficulty making a culture-based diagnosis when melioidosis has not been considered in the differential diagnosis. Melioidosis is most likely underdiagnosed in tropical Central and South America where conditions are more suited to persistence of B. pseudomallei in the environment. Recent melioidosis case clusters in northeastern Brazil highlight the threat posed to rural populations located far from specialist services. Increased clinical awareness of the disease and improvements in laboratory diagnostic methods are likely to bring wider recognition of melioidosis in the Americas.

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Section: Latin Americamentioning

confidence: 99%

Melioidosis in the Americas

Inglis¹,

Rolim²,

SOUSA³

2006

The American Journal of Tropical Medicine and Hygiene

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“…In one study, B. pseudomallei was recovered from environmental specimens (soap, floor, and shower hose) in a burn unit of a hospital in Belo Horizonte, Brazil. 27 A prior review of melioidosis cases in the Americas described 105 cases with an association (residence when diagnosed, travel history, or country of birth) to the Americas. 28 Two of the cases (one case reported from Oklahoma in 1976 and the other reported from Georgia in 1979) have since been reclassified as infections with the closely related bacteria Burkholderia oklahomensis.…”

Section: Introductionmentioning

confidence: 99%

A Review of Melioidosis Cases in the Americas

Benoit¹,

Blaney²,

Doker³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Melioidosis is a bacterial infection caused by Burkholderia pseudomallei, a gram-negative saprophytic bacillus. Cases occur sporadically in the Americas with an increasing number of cases observed among people with no travel history to endemic countries. To better understand the incidence of the disease in the Americas, we reviewed the literature, including unpublished cases reported to the Centers for Disease Control and Prevention. Of 120 identified human cases, occurring between 1947 and June 2015, 95 cases (79%) were likely acquired in the Americas; the mortality rate was 39%. Burkholderia pseudomallei appears to be widespread in South, Central, and North America.

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Melioidosis: Epidemiology, Pathophysiology, and Management

2005

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Melioidosis, caused by the gram-negative saprophyte Burkholderia pseudomallei, is a disease of public health importance in southeast Asia and northern Australia that is associated with high case-fatality rates in animals and humans. It has the potential for epidemic spread to areas where it is not endemic, and sporadic case reports elsewhere in the world suggest that as-yet-unrecognized foci of infection may exist. Environmental determinants of this infection, apart from a close association with rainfall, are yet to be elucidated. The sequencing of the genome of a strain of B. pseudomallei has recently been completed and will help in the further identification of virulence factors. The presence of specific risk factors for infection, such as diabetes, suggests that functional neutrophil defects are important in the pathogenesis of melioidosis; other studies have defined virulence factors (including a type III secretion system) that allow evasion of killing mechanisms by phagocytes. There is a possible role for cell-mediated immunity, but repeated environmental exposure does not elicit protective humoral or cellular immunity. A vaccine is under development, but economic constraints may make vaccination an unrealistic option for many regions of endemicity. Disease manifestations are protean, and no inexpensive, practical, and accurate rapid diagnostic tests are commercially available; diagnosis relies on culture of the organism. Despite the introduction of ceftazidime- and carbapenem-based intravenous treatments, melioidosis is still associated with a significant mortality attributable to severe sepsis and its complications. A long course of oral eradication therapy is required to prevent relapse. Studies exploring the role of preventative measures, earlier clinical identification, and better management of severe sepsis are required to reduce the burden of this disease

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Bacteriological evaluation of wounds in seriously burned hospitalized patients

Cited by 3 publications

References 15 publications

Melioidosis in the Americas

Melioidosis in the Americas

A Review of Melioidosis Cases in the Americas

Melioidosis: Epidemiology, Pathophysiology, and Management

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