Schistosoma mansoni: evolução de vermes oriundos de cercárias irradiadas a nível de sistema porta, no camundongo

S, Cardoso Gde; Pm, Coelho

doi:10.1590/s0037-86821989000400007

Cited by 5 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the irradiation is expected to provide around 4% of non-sterile worms, as previously demonstrated. 14,16 Although the number of the worms recovered from portal veins in both irradiated and non-irradiated infection were fewer than expected, the portal tract perfusion experiments confirmed the presence of worms in all infected mice. Hence this experimental model is appropriate since a pair of worms in a mouse has been shown to be equivalent to a severe infection in humans.…”

Section: Discussionmentioning

confidence: 83%

“…12 The LE strain has been maintained for more than 30 years at the Schistosomiasis Research Unit (Laboratory of Dr. José Pellegrino, Federal University of Minas Gerais, Brazil) by serial passage through Biomphalaria glabrata and hamsters (Mesocricetus auratus). Another group of mice were infected with 250 LE cercariae irradiated with 3 Kr of gamma irradiation of Cobalt-60, to sterilize the female worms [13][14][15][16][17] and to prevent the deposition of eggs in the liver parenchyma.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

Teixeira

Coelho²,

Filho³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Schistosomiasis mansoni infection that occurs concurrently with Staphylococcus aureus bacteremia favors the formation of pyogenic liver abscess. The present experimental study in mice evaluated the following aspects of the relationship between infection with Schistosoma mansoni and liver abscess caused by S. aureus: a) the role of the eggs of S. mansoni in the genesis of the abscesses; b) the influence of different phases of schistosomiasis in the development of liver abscesses; and c) the effect of the treatment of schistosomiasis on the development of the abscesses. Macroscopic and histopathological study showed multiple liver abscesses around granulomas of S. mansoni in the acute and chronic phases of schistosomiasis. Treatment of acute schistosomiasis before experimentally-induced bacteremia did not prevent the formation of liver abscess. The study findings indicate that granulomas around S. mansoni eggs and worms lodged in the liver provide a focus and substrate for pyogenic abscesses caused by S. aureus.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

Teixeira

Coelho²,

Filho³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…As a typical active compound isolated from Cistanche herba, ECH has strong anti-inflammatory and antioxidant activities and can improve blood sugar levels. , Oxidative stress is defined as the overproduction of reactive oxygen species that can trigger oxidative damage leading to cellular oxidative damage, which in turn leads to cancer, neurodegeneration, cardiovascular disease, diabetes, and renal disease. − Glycation and oxidative damage are closely related in vivo , with glycation (glycosylation) disrupting redox homeostasis and oxidative stress driving glycation. , Thus, redox homeostasis also has a great effect on the treatment of cutaneous glycation. Studies on ECH related to the skin have also focused primarily on antioxidation and skin protection.…”

Section: Discussionmentioning

confidence: 99%

“… 32 − 34 Glycation and oxidative damage are closely related in vivo , with glycation (glycosylation) disrupting redox homeostasis and oxidative stress driving glycation. 35 , 36 Thus, redox homeostasis also has a great effect on the treatment of cutaneous glycation. Studies on ECH related to the skin have also focused primarily on antioxidation and skin protection.…”

Section: Discussionmentioning

confidence: 99%

Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products

Sun

Hou

et al. 2023

ACS Nano

View full text Add to dashboard Cite

Glycation is a nonenzymatically catalyzed spontaneous reaction that eventually leads to the formation of advanced glycation end-products (AGEs), which can bind to the receptor for AGEs (RAGE). The consequences are oxidative damage, an inflammatory response, and aging. In this work, we synthesized echinacoside-zinc coordination polymers (ECH-Zn) by using the coordination interaction between the catechol group of ECH and zinc ions. ECH-Zn was further wrapped with hyaluronic acid/poly (ethylenimine) (HA-PEI) to obtain spherical nanoparticle polymers of HA-PEI-coated ECH-Zn (PPZn). PPZn can enhance the uptake and utilization of ECH-Zn and also have a better antiglycation effect in the skin under the effect of promoting transdermal absorption of HA-PEI. Mechanistic studies at the cellular level showed that MDM2 can interact with STAT2 to form a transcriptional complex and thus promote RAGE transcriptional activation. In vitro and in vivo studies revealed that PPZn can decrease the expression and inhibit the interaction of the MDM2/STAT2 complex. It inhibited the function of the MDM2/STAT2 complex and suppressed the transcriptional activation of RAGE, thereby exerting antiglycation effects. In conclusion, this work provides a nanomaterial and elucidated a mechanism of anti-skin glycation.

show abstract

Molecular characterization of a calcium-binding protein SjCa8 from Schistosoma japonicum

Law

Lv³

et al. 2008

Parasitol Res

View full text Add to dashboard Cite

A full-length cDNA encoding a cercarial stage-specifically expressed 8-kDa calcium-binding protein (SjCa8) was isolated from Schistosoma japonicum cercarial cDNA library using microarray screen. The putative gene coding for SjCa8 is of 371 bp with an open reading frame of 69 amino acid (aa). The deduced aa sequence showed 83% identity with the Schistosoma mansoni 8-kDa CaBP, 47% identity with Clonorchis sinensis calcium-binding protein, and 38% identity with Fasciola hepatica putative calcium-binding protein. Also, it shares more than 30% identity with the calmodulin of many different species, while the most significant similarity between them lies around the two calcium-binding loop regions. There are two potential sites for phosphorylation and one potential site for N-myristoylation in the sequence. The SjCa8 has also been predicted to contain a single pair of EF-hand Ca2+-binding domain. The recombinant SjCa8 (rSjCa8) protein expressed and purified from E. coli has been demonstrated to possess the calcium-binding activity. Immune serum from UV-attenuated S. japonicum cercariae-immunized rabbit detected rSjCa8 by Western blot assay, while the sera from S. japonicum naturally infected rabbit and normal rabbit could not. These findings may contribute to the development of an effective vaccine against schistosomiasis.

show abstract

Schistosoma mansoni: evolução de vermes oriundos de cercárias irradiadas a nível de sistema porta, no camundongo

Cited by 5 publications

References 2 publications

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products

Molecular characterization of a calcium-binding protein SjCa8 from Schistosoma japonicum

Contact Info

Product

Resources

About