Isolation and functional characterization of mononuclear phagocytes from human lepromatous lesions

Sarno, Euzenir Nunes; Sampaio, Elizabeth P.; Moreira, André L.; Alvarenga, Fátima de Barros Fonseca

doi:10.1590/s0037-86821987000400004

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“…In that sense, the ability to isolate ex vivo macrophages from skin biopsies is of note [149]. The feasibility of obtaining cells from leprosy lesions and keeping them in long-term culture has been demonstrated [149,150].…”

Section: Future Perspectivementioning

confidence: 99%

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Mycobacterium Leprae –Host-Cell Interactions and Genetic Determinants in Leprosy: an Overview

et al. 2011

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Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae in which susceptibility to the mycobacteria and its clinical manifestations are attributed to the host immune response. Even though leprosy prevalence has decreased dramatically, the high number of new cases indicates active transmission. Owing to its singular features, M. leprae infection is an attractive model for investigating the regulation of human immune responses to pathogen-induced disease. Leprosy is one of the most common causes of nontraumatic peripheral neuropathy worldwide. The proportion of patients with disabilities is affected by the type of leprosy and delay in diagnosis. This article briefly reviews the clinical features as well as the immunopathological mechanisms related to the establishment of the different polar forms of leprosy, the mechanisms related to M. leprae-host cell interactions and prophylaxis and diagnosis of this complex disease. Host genetic factors are summarized and the impact of the development of interventions that prevent, reverse or limit leprosy-related nerve impairments are discussed.

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Section: Future Perspectivementioning

confidence: 99%

“…The feasibility of obtaining cells from leprosy lesions and keeping them in long-term culture has been demonstrated [149,150]. These procedures may open new pathways to study the interaction between M. leprae and human macrophages.…”

Section: Future Perspectivementioning

confidence: 99%

Mycobacterium Leprae –Host-Cell Interactions and Genetic Determinants in Leprosy: an Overview

et al. 2011

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Isolation and functional characterization of mononuclear phagocytes from human lepromatous lesions

Abstract: In the present study, inflammatory cells from human lepromatous lesions were isolated by enzymatic dissociation of tissue. They were maintained in culture up to five days and their morphologic, cythochemicaland functional characteristics were described.

Cited by 1 publication

References 8 publications

Mycobacterium Leprae –Host-Cell Interactions and Genetic Determinants in Leprosy: an Overview

Mycobacterium Leprae –Host-Cell Interactions and Genetic Determinants in Leprosy: an Overview

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