Absence of clinical abnormalities suggesting renal involvement during the long-term course of visceral Leishmaniasis

Canine visceral leishmaniasis frequently causes glomerulonephritis and tubulointerstitial nephritis, nephropathies for which diagnosis has been limited by the low sensitivity of traditional tests. The aim of this study was to evaluate serum cystatin C and urinary gamma-glutamyltransferase (uGGT) levels and the urinary GGT/urinary creatinine ratio (uGGT/uCR) and to measure the renal arterial resistive index (RARI) in dogs with leishmaniasis with varying degrees of renal injury based on the urine protein: creatinine ratio (UP/C) and serum creatinine (SCr) level. We tested 59 untreated adult dogs of both sexes and undefined breeds naturally infected with Leishmania infantum. The dogs were grouped into four groups based on UP/C and SCr level: group 1 (n = 15), dogs with SCr levels < 1.4 mg/dL and UP/C < 0.5; group 2 (n = 13), dogs with SCr levels < 1.4 mg/dL and UP/C of 0.5-1.0; group 3 (n = 16), dogs with SCr levels < 1.4 and UP/C > 1.0; and group 4 (n = 15), dogs with SCr levels > 1.4. A fifth group of healthy dogs (n = 10) was the control. uGGT concentrations and uGGT/uCR were higher in dogs with proteinuria and SCr < 1.4 mg/dL, whereas the serum cystatin C concentrations and RARI were higher only in dogs with SCr levels > 1.4. In conclusion, uGGT and uGGT/uCR may be useful tools for early detection and assessment of renal lesions associated with leishmaniasis; however, cystatin C is useful for monitoring the progression of kidney disease when measured sequentially.

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Biomarkers and renal arterial resistive index in dogs naturally infected with Leishmania infantum

Frazilio

Borges

Souza

et al. 2018

Parasitol Res

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Comparative Analysis of Pediatric and Adult Visceral Leishmaniasis in Brazil

Rocha

Oliveira²,

Franco³

et al. 2013

Pediatric Infectious Disease Journal

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Risk Factors for Acute Kidney Injury in Visceral Leishmaniasis (Kala-Azar)

Oliveira

Júnior²,

Abreu³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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The aim of this study was to investigate the factors associated with acute kidney injury (AKI) in patients with visceral leishmaniasis (VL). The study patients had a diagnosis of VL and were admitted to a tertiary hospital. A multivariate analysis was performed to analyze the risk factors for AKI. A total of 224 patients were included. The mean age was 36 ± 15 years. AKI was observed in 33.9% of cases. Risk factors associated with AKI were male gender (odds ratio [OR] = 2.2; P = 0.03), advanced age (OR = 1.05; P < 0.001), and jaundice (OR = 2.9; P = 0.002). There was an association between amphotericin B use and AKI (OR = 18.4; P < 0.0001), whereas glucantime use was associated with lower incidence of AKI compared with amphotericin B use (OR = 0.05; P < 0.0001). Mortality was 13.3%, and it was higher in AKI patients (30.2%). Therefore, factors associated with AKI were male gender, advanced age, and jaundice. Amphotericin B was an important cause of AKI in VL.

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Absence of clinical abnormalities suggesting renal involvement during the long-term course of visceral Leishmaniasis

Abstract: Abnormalities o f renalfunction have been demonstrated inpatients with visceral

Cited by 3 publications

References 18 publications

Biomarkers and renal arterial resistive index in dogs naturally infected with Leishmania infantum

Biomarkers and renal arterial resistive index in dogs naturally infected with Leishmania infantum

Comparative Analysis of Pediatric and Adult Visceral Leishmaniasis in Brazil

Risk Factors for Acute Kidney Injury in Visceral Leishmaniasis (Kala-Azar)

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