Procedência de pacientes com leishmaniose de mucosa em área endêmica da Bahia, Brasil

One of the more serious clinical forms of leishmaniasis occurs in espundia when the mucosae of the upper respiratory passages are inflamed. This complication is a metastasis from a skin lesion caused by Leishmania braziliensis braziliensis (Lbb) although cases have been described associated with other leishmanial species. Epidemiological data suggest that a detectable mucosal metastasis occurs in fewer than 5% of patients infected with Lbb in our study area. The determinants of this complication are still largely obscure. The granuloma usually commences on the nasal septum. In about two-thirds of our patients the lesion remained restricted to the nose. In the rest the pharynx, palate, larynx and lips were involved, in this order. It is often difficult to isolate the parasite and for routine diagnosis the leishmanin skin reaction and serological tests are helpful. Although a serious condition, with possible mutilation and even death as subsequent complications, treatment is still mainly with pentavalent antimonials, introduced 40 years ago. These are most unsatisfactory for field use, being given parenterally and relatively toxic. In mucosal leishmaniasis, if sufficient antimony can be administered in a regular daily dose, the relapse rate is small (3 of 42 patients followed for a mean of 5 years). Also, antimony treatment of the initial skin ulcer due to Lbb followed for a mean of 4 years of 83 patients resulted in subsequent mucosal metastasis in only 2. Since espundia is relatively rare, specific treatment targeted to this specific problem is the efficient short term solution. At present there is no satisfactory alternative drug to those in current use.

show abstract

Mucosal leishmaniasis (“spundia” Escomel, 1911)

Marsden

1986

Transactions of the Royal Society of Tropical Medicine and Hygi

338

178

View full text Add to dashboard Cite

show abstract

Predominance of Leishmania braziliensis braziliensis in the regions of Três Braços and Corte de Pedra, Bahia, Brazil

Rosa

Cuba

Vexenat

et al. 1988

Transactions of the Royal Society of Tropical Medicine and Hygi

View full text Add to dashboard Cite

Unusual prevalence of Leishmania braziliensis braziliensis in four families

Wong

Netto

Wiese

et al. 1986

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Procedência de pacientes com leishmaniose de mucosa em área endêmica da Bahia, Brasil

Cited by 4 publications

References 2 publications

Mucosal leishmaniasis (“spundia” Escomel, 1911)

Mucosal leishmaniasis (“spundia” Escomel, 1911)

Predominance of Leishmania braziliensis braziliensis in the regions of Três Braços and Corte de Pedra, Bahia, Brazil

Unusual prevalence of Leishmania braziliensis braziliensis in four families

Contact Info

Product

Resources

About