Leishmania mexicana amazonensis isolated from a patient with fatal mucosal leishmaniasis

Sampaio, Raimunda Nonata Ribeiro; Marsden, Philip D.; Cuentas, Elmer Alejandro Llanos; Cuba, César Augusto Cuba; Grimaldi, Gabriel

doi:10.1590/s0037-86821985000400015

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…2,3 Leishmania (L.) amazonensis has also been implicated in non-cutaneous forms of the disease such as mucosal, visceral, and post-kala-azar dermal leishmaniasis. 4,5 Visceral leishmaniasis can also be caused by L. (L.) amazonensis in patients with associated infections with human immunodeficiency virus. 6 It has been shown that BALB/c mice are highly susceptible to L. (L.) amazonensis, and show a progressive infection that may disseminate to lymph nodes, spleen, and liver, and promote metastasis in almost all extremities of the animal body.…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

Abreu-Silva

Calabrese²,

Tedesco³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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Abstract. We describe the pathologic alterations of the central nervous system (CNS) observed in experimental tegumentary leishmaniasis in BALB/c and Swiss mice. The mice were subcutaneously infected with 10 4 amastigotes of Leishmania (Leishmania) amazonensis. Animals were killed and brains were removed for histologic and immunocytochemical studies. Histologic examination showed that 66.6% of infected mice had a discrete hyperemia and inflammatory infiltrate in the meninges, composed of mononuclear cells and neutrophils with no detectable parasites. However, parasitized macrophages were detected in the cerebral parenchyma, as well as mast cells, lymphocytes, and polymorphonuclear cells. Necrosis in the cerebral parenchyma was also observed. Confocal fluorescence microscopy showed that CD8 + T lymphocytes are the major component of the inflammatory infiltrate in the CNS. In addition to these cells, CD4 + , CD11b, and dendritic cells are present, in small numbers, in the inflammatory processes of the CNS. Thus, L. amazonensis is able to cross the blood-brain barrier and cause significant pathologic changes in the CNS.

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Section: Introductionmentioning

confidence: 99%

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

Abreu-Silva

Calabrese²,

Tedesco³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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“…It is also important to note that there are some reported cases of primary or secondary CL lesions after localized trauma, and these lesions can appear months later 4,5 . In our experience of more than 2,000 cases of ATL, we have observed 3 cases triggered by trauma: one after a bicycle trauma on the ankle cause by L. (L.) amazonensis 9 ; one after a snake bite; and one after a laser hair removal procedure. In addition, previous studies in murine models infected with Leishmania support the possibility of metastatic cutaneous lesions at sites of trauma 5 .…”

Section: Discussionmentioning

confidence: 98%

American cutaneous leishmaniasis triggered by electrocoagulation

Martins

Santos

Lima

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Cutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis confirmed by dermatoscopy. Three months later, a skin fragment tested positive for Leishmania culture; the parasite was identified as L. (V.) braziliensis. Trauma may generate inflammatory cascades that favor Leishmania growth and lesion formation in previously infected patients. American cutaneous leishmaniasis is a dynamic disease with unclear pathophysiology because of continually changing environments, demographics, and human behaviors.

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“…Freqüentemente ocasiona uma desfiguração facial extensa, provocando problemas de ordem social de grande complexidade, debilitando e incapacitando pacientes com conseqüente redução da força de trabalho em determinadas regiões, podendo, assim, criar um ciclo vicioso de pobreza e constituir barreira ao progresso (DESJEUX, 1996). Quando acomete mucosas pode evoluir progressivamente comprometendo as regiões de orofaringe e nasofaringe, tendo como desfecho até mesmo a morte (SAMPAIO et al, 1985). É causada por parasitas do gênero Leishmania agrupadas nos subgêneros Leishmania (Viannia) e Leishmania (Leishmania) (LAINSON & SHAW, 1987).…”

Section: Introductionunclassified

"Avaliação da reação em cadeia de polimerase (PCR) no diagnóstico da leishmaniose cutânea no Estado do Espírito Santo, Brasil"

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Leishmania mexicana amazonensis isolated from a patient with fatal mucosal leishmaniasis

Cited by 14 publications

References 4 publications

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

Central Nervous System Involvement in Experimental Infection With Leishmania (Leishmania) Amazonensis

American cutaneous leishmaniasis triggered by electrocoagulation

"Avaliação da reação em cadeia de polimerase (PCR) no diagnóstico da leishmaniose cutânea no Estado do Espírito Santo, Brasil"

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