Experimental paracoccidioidomycosis in the mouse. III. Histopathological and immunological findings after intravenous infection in the presence or absence of previous immunization

Abstract

a) the im m unized anim ais developed m ore intense cell-im m une responses than the infected ones; b) infection reduced the cellim m une response o f the im m unized anim ais; c) intravenous infection o f mice with P. brasiliensis was characterized by a system ic and progressive granulom atous inflam m ation. The anim ais infected after previous im m unization showed less extensive lung inflam m ation, with sm allergranulom as andfew erfu n g i. The results indicate that the present m urine m odel m im ics som e fin d in g s o f the hum an subacute fo rm o f paracoccidioidom ycosis (system ic disease with depressed cellular im m unity) and that the extrapulm onary im m unization schem e was able to induce a certain degree o f protection o f the lung fro m infection with P. brasiliensis