Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease

Veiga, Joel Paulo Russomano; Kimachi, Tatsuto; Filho, Euclydes C. Lima

doi:10.1590/s0037-86821985000200005

Cited by 2 publications

(1 citation statement)

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“…Moreover, considering the intricate relationship between different organ systems and processes, the proper cardiac autonomic dysfunction is expected to be correlated with metabolic, hormonal and functional renal disturbances. Indeed, cardiac autonomic dysfunction has been observed in chagasic subjects with either indeterminate or cardiac forms of the disease and in experimentally Trypanosoma cruzi-infected animals simultaneously with altered osmoregulation dependent on the antidiuretic hormone response 85 , altered hydroelectrolytic balance 86 and altered glucose tolerance 87 .…”

Section: Other Possible Effects Of Autonomic Dysfunctionmentioning

confidence: 99%

Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease

Junqueira Junior

2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: Exclusive or associated lesions in various structures of the autonomic nervous system occur in the chronic forms of Chagas disease. In the indeterminate form, the lesions are absent or mild, whereas in the exclusive or combined heart and digestive disease forms, they are often more pronounced. Depending on their severity these lesions can result mainly in cardiac parasympathetic dysfunction but also in sympathetic dysfunction of variable degrees. Despite the key autonomic effect on cardiovascular functioning, the pathophysiological and clinical significance of the cardiac autonomic dysfunction in Chagas disease remains unknown. METHODS: Review of data on the cardiac autonomic dysfunction in Chagas disease and their potential consequences, and considerations supporting the possible relationship between this disturbance and general or cardiovascular clinical and functional adverse outcomes. RESULTS: We hypothesise that possible consequences that cardiac dysautonomia might variably occasion or predispose in Chagas disease include: transient or sustained arrhythmias, sudden cardiac death, adverse overall and cardiovascular prognosis with enhanced morbidity and mortality, an inability of the cardiovascular system to adjust to functional demands and/or respond to internal or external stimuli by adjusting heart rate and other hemodynamic variables, and immunomodulatory and cognitive disturbances. CONCLUSIONS: Impaired cardiac autonomic modulation in Chagas disease might not be a mere epiphenomenon without significance. Indirect evidences point for a likely important role of this alteration as a primary predisposing or triggering cause or mediator favouring the development of subtle or evident secondary cardiovascular functional disturbances and clinical consequences, and influencing adverse outcomes.

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Section: Other Possible Effects Of Autonomic Dysfunctionmentioning

confidence: 99%